Kadar TNF ( Mikroenkapsulasi Sel Punca Hematopoietik CD34+

Authors

  • Christine Verawaty Sibuea Universitas HKBP Nomensen
  • Joseph Partogi Sibarani Universitas HKBP Nomensen
  • Rachel Teodora Silaen Universitas HKBP Nomensen
  • Christina br Samosir Universitas HKBP Nomensen
  • Glenessa Kuara Universitas HKBP Nomensen
  • Kharnis Marsha Madora Ginting Universitas HKBP Nomensen

DOI:

https://doi.org/10.31004/jn.v7i2.26029

Abstract

Sel punca hematopoietik CD34+ memiliki memiliki kemampuan angiogenik, plastisitas dan sebagai imunoregulator. Hal ini menyebabkan sel punca hematopoietik CD34+ banyak digunakan pada terapi seluler. Rendahnya kemampuan proliferasi dan rendahnya viabilitas migrasi ke host, memberikan keterbatasan pendekatan terapi seluler yang menggunakan sel punca hematopoietik CD34+. Enkapsulasi mempertahankan fungsi sel punca hematopoietik CD34+ dan dapat meregulasi sistem imun. Tumor Necrosis Factor ( (TNF() merupakan molekul pro-inflamasi yang berperan penting dalam imunoregulasi. TNF( berperan penting dalam reaksi penolakan transplantasi sel punca hematopoietik CD34+. Penelitian ini menganalisa kadar TNF(pada enkapsulasi sel punca hematopoietik CD34+. Sel punca hematopoietik CD34+ dikapsulasi dengan menggunakan alginate cross linked dengan CaCl2, dan dikultur hingga 21 hari. Kadar TNF( dianalisa dengan metode ELISA. Kadar TNF( menurun pada hari ke-7 dan tidak ditemukan hingga hari ke-21. Enkapsulasi menurunkan kadar TNF( dan dapat digunakan untuk pengembangan terapi seluler sel punca hematopoietik CD34+.

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Published

2023-10-31

How to Cite

Sibuea, C. V. ., Sibarani, J. P. ., Silaen, R. T., Samosir, C. br ., Kuara , G., & Ginting, K. M. M. (2023). Kadar TNF ( Mikroenkapsulasi Sel Punca Hematopoietik CD34+. Jurnal Ners, 7(2), 1879–1882. https://doi.org/10.31004/jn.v7i2.26029

Issue

Vol. 7 No. 2 (2023): OKTOBER 2023

Section

Articles

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Copyright (c) 2023 Jurnal Ners

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