EFEKTIVITAS DIET KETOGENIK SEBAGAI TERAPI ADJUVAN PADA PENYAKIT GLIOBLASTOMA
DOI:
https://doi.org/10.31004/prepotif.v9i3.53761Keywords:
Glioblastoma, Diet Ketogenik, Terapi AdjuvanAbstract
Glioblastoma Multiforme (GBM) merupakan tumor otak primer paling agresif dengan prognosis yang buruk meskipun telah menjalani standar perawatan bedah, radiasi, dan kemoterapi. Penelitian ini bertujuan untuk menganalisis efektivitas diet ketogenik (KD) sebagai terapi adjuvan metabolik dalam meningkatkan luaran klinis pasien GBM. Metode yang digunakan adalah literature review terhadap sepuluh studi klinis utama dan literatur pendukung yang relevan. Hasil analisis menunjukkan bahwa KD secara efektif menginduksi ketosis terapeutik yang mampu mengeksploitasi kerentanan metabolik sel tumor melalui pembatasan glukosa. Pasien yang patuh mempertahankan Glucose Ketone Index (GKI) di bawah 2,0 menunjukkan peningkatan signifikan pada Overall Survival (OS) dan Progression-Free Survival (PFS). Dari sisi keamanan, intervensi ini dinilai layak dan aman dengan manfaat tambahan berupa perlindungan fungsi neurokognitif dan stabilitas kualitas hidup pasien. Kesimpulannya, diet ketogenik merupakan strategi terapi adjuvan yang efektif dan rasional untuk memperkuat efikasi pengobatan standar pada glioblastoma derajat tinggi.References
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