HUBUNGAN LAMA MENDERITA DIABETES MELLITUS TIPE 2 DENGAN DERAJAT KEPARAHAN OSTEOARTHRITIS LUTUT PADA WANITA MENOPAUSE DI RSUD DR. MOHAMAD SOEWANDHIE
DOI:
https://doi.org/10.31004/prepotif.v9i3.52506Keywords:
Diabetes Mellitus Tipe 2, Durasi Penyakit, Kellgren and Lawrence, Menopause, Osteoarthritis LututAbstract
Diabetes Mellitus Tipe 2 (DMT2) merupakan penyakit metabolik kronis yang tidak hanya menimbulkan komplikasi vaskular, tetapi juga berkontribusi terhadap gangguan muskuloskeletal, termasuk osteoarthritis (OA) lutut. Kondisi hiperglikemia kronis dapat mempercepat proses degeneratif sendi melalui pembentukkan advanced glycation end products (AGEs) dan reactive oxygen species (ROS). Perubahan biologis ini berpotensi memperberat OA lutut, khsusunya pada wanita menopause yang mengalami penurunan kadar hormon estrogen sehingga memicu peningkatan proses inflamasi serta penurunan elastisitas jaringan sendi. Penelitian ini bertujuan untuk menganalisis hubungan antara lama menderita DMT2 dengan derajat keparahan OA lutut pada wanita menopause di RSUD Dr. Mohamad Soewandhie Surabaya. Penelitian menggunakan rancangan cross-sectional analytic dengan teknik purposive sampling. Sampel terdiri dari 78 wanita menopause dengan DMT2 yang disertai OA lutut, sesuai dengan kriteria inklusi dan eksklusi yang telah ditetapkan. Data diperoleh dari rekam medis dan wawancara langsung, meliputi lama menderita DMT2 serta hasil radiografi polos lutut untuk menentukan derajat keparahan OA berdasarkan klasifikasi Kellgren and Lawrence. Analisis hubungan antarvariabel dilakukan menggunakan uji Chi-Square dengan tingkat signifikansi p < 0,05. Mayoritas responden berusia ≥ 60 tahun (66,7%) dan telah menderita DMT2 selama ≥ 5 tahun (55,1%). Sebagian besar pasien mengalami OA lutut derajat 3 (50,0%) dan derajat 4 (35,0%). Hasil analisis Chi-Square memperlihatkan nilai p-value sebesar 0,450 (p > 0,05). Tidak terdapat hubungan signifikan antara lama menderita DMT2 dan derajat keparahan OA lutut pada wanita menopause.References
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