PUBERTAS PREKOKS IDIOPATIK TIPE SENTRAL PADA ANAK PEREMPUAN USIA 8 TAHUN 11 BULAN : CASE REPORT
DOI:
https://doi.org/10.31004/prepotif.v9i3.52392Keywords:
anak perempuan, idiopatik, pubertas prekoksAbstract
Pubertas prekoks merupakan kondisi perkembangan seksual sekunder yang muncul lebih awal dari usia normal, yaitu sebelum usia 8 tahun pada anak perempuan. Laporan ini membahas seorang anak perempuan usia 8 tahun 11 bulan dengan diagnosis pubertas prekoks sentral idiopatik. Pasien datang dengan keluhan pembesaran payudara sejak satu tahun sebelumnya tanpa disertai pertumbuhan rambut pubis atau menarke. Pemeriksaan hormon menunjukkan kadar LH dan estradiol meningkat, serta bone age lebih maju dibanding usia kronologis. Pemeriksaan radiologi tidak menunjukkan kelainan pada sistem saraf pusat. Pasien didiagnosis dengan pubertas prekoks sentral idiopatik dan mendapat terapi agonis GnRH (Leuprorelin) setiap bulan. Penanganan dini dan teratur penting untuk mencegah komplikasi seperti gangguan psikososial, pertumbuhan tidak optimal, dan haid dini. Prognosis pasien baik dengan pemantauan dan dukungan keluarga yang optimal.References
Batubara JRL. (2010). Gonadothropin-releasing hormon agonist as a treatment of choice for central precocius puberty. Med J Indones. 19: 287-92
Berberoğlu M. (2009). Precocious puberty and normal variant puberty: definition, etiology, diagnosis and current management. J Clin Res Pediatr Endocrinol.;1(4):164-74. [PMC free article] [PubMed]
Bigambo FM, Wang D, Niu Q, Zhang M, Mzava SM, Wang Y, Wang X. (2023). The effect of environmental factors on precocious puberty in children: a case-control study. BMC Pediatr. May 1;23(1):207. doi: 10.1186/s12887-023-04013-1. PMID: 37127587; PMCID: PMC10149633.
Calcaterra V, Verduci E, Magenes VC, Pascuzzi MC, Rossi V, Sangiorgio A, Bosetti A, Zuccotti G, Mameli C. (2021). The Role of Pediatric Nutrition as a Modifiable Risk Factor for Precocious Puberty. Life (Basel). Dec 7;11(12):1353. doi: 10.3390/life11121353. PMID: 34947884; PMCID: PMC8706413.
Chapman IM. (2019). Overview of the Pituitary Gland. Hormonal and Metabolic Disorders.
Delman BN. (2009). Imaging of Pediatric Pituitary Abdormalities. Endocrinol Metab Clin N Am. 38: 673-698.
Dong Y, Dai L, Dong Y, Wang N, Zhang J, Liu C, Li Z, Chu L, Chen S. (2023). Analysis of risk factors of precocious puberty in children. BMC Pediatr. Sep 11;23(1):456. doi: 10.1186/s12887-023-04265-x. Erratum in: BMC Pediatr. 2023 Sep 22;23(1):482. doi: 10.1186/s12887-023-04320-7. PMID: 37697362; PMCID: PMC10494349.
Faizi M, Artati RD, Pulungan AB. (2017). Diagnosis dan Tata Laksana Pubertas Prekoks Sentral. Jakarta: Ikatan Dokter Indonesia.
Guillen LS, Argente J. (2019). Central Precocious Puberty, Functional and Tumor-Related. Best Practice & Research Clinical Endocrinology & Metabolism. http://doi.org/10.1016/j.beem.2019.01.003
Haddad NG, Eugster EA. (2019). Peripheral precocious puberty including congenital adrenal hyperplasia: causes, consequences, management and outcomes. Best Pract Res Clin Endocrinol Metab. Jun;33(3):101273. [PubMed]
IDAI. (2013). Masalah Pubertas pada Anak dan Remaja. Indonesia Pediatric Society.
Kiess W, Hoppmann J, Gesing J, Penke M, Körner A, Kratzsch J, Pfaeffle R. (2016). Puberty - genes, environment and clinical issues. J Pediatr Endocrinol Metab. Nov 01;29(11):1229-1231. [PubMed]
Long D. (2015). Precocious Puberty. Pediatrics in Review.;36(7):319-321.
Michel Dubuis J. (2017). Puberty : Physiology [Internet]. Gfmer.ch. 2016 [cited 20 May]. Available from: http://www.gfmer.ch/Endo/Lectures_10/Puberty_%20Physiology.htm
Pulungan AB. (2010). Pubertas dan gangguannya. Buku Ajar Endokrinologi Anak. 6: 95-104.
Rieth KG, Comite F, Dwyer AJ, Nelson MJ, Pescovitz O, Shawker TH, Cutler GB, Loriaux DL. (1987). CT of Cerebral Abnormalities in Precocious Puberty. AJNR 8: 283-290.
Shi L, Jiang Z, Zhang L. (2022). Childhood obesity and central precocious puberty. Front Endocrinol (Lausanne). Nov 18;13:1056871. doi: 10.3389/fendo.2022.1056871. PMID: 36465655; PMCID: PMC9716129.
Teilmann G, Pedersen CB, Jensen TK, Skakkebaek NE, Juul A. (2005). Prevalence and incidence of precocious pubertal development in Denmark: an epidemiologic study based on national registries. Pediatrics. Dec;116(6):1323-8. [PubMed]
Wang Y, Gou H, Guo J. (2025). Risk factors for precocious puberty: A systematic review and meta analysis. Psychoneuroendocrinology. Jun;176:107427. doi: 10.1016/j.psyneuen.2025.107427. Epub 2025 Mar 10. PMID: 40081314.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Abdi Dwiyanto Putra Samosir, Ratna Dewi Artati, Amiruddin L Amiruddin , Kwari Januar Satriono
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work’s authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal’s published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
