THE RELATIONSHIP BETWEEN CHRONIC KIDNEY DISEASE AND ISCHEMIC EVENTS IN HEMODIALYSIS PATIENTS AT RAA SOEWONDO PATI REGIONAL HOSPITAL
DOI:
https://doi.org/10.31004/prepotif.v9i3.50926Keywords:
Chronic Kidney Disease, Ischemic Events, Myocardial Ischemia, Diabetes Mellitus, HemodialysisAbstract
Diperkirakan 800 juta orang di seluruh dunia diantisipasi akan terkena penyakit ginjal kronis (PGK) pada tahun 2017, menjadikannya beban kesehatan global yang signifikan. Lanskap mortalitas telah menunjukkan tren yang memprihatinkan, dengan CKD meningkat secara signifikan dalam peringkat global penyebab utama kematian dari posisi ke-19 pada tahun 2013 menjadi ke-13 pada tahun 2016 dan ke-12 pada tahun 2017 naik menjadi penyebab kematian paling umum kelima pada tahun 2040. Kejadian iskemik, atau iskemia miokardium diam, yang ditandai dengan perubahan elektrokardiografi (EKG) asimtomatik, termasuk inversi gelombang T dan depresi segmen ST, merupakan komplikasi kardiovaskular yang meluas dan kurang dikenali yang memengaruhi pasien hemodialisis. Tujuan penelitian ini adalah untuk mengetahui hubungan antara CKD dengan kejadian iskemia pada pasien hemodialisis. Penelitian ini merupakan penelitian observasional potong lintang antara September dan November 2024, yang dilakukan di Rumah Sakit Daerah RAA Soewondo Pati. Prosedur EKG dilakukan selama hemodialisis. Kami melakukan analisis statistik menggunakan uji chi-square. Sampel dalam penelitian ini berjumlah 50 orang. Usia pasien berkisar antara 43 hingga 65 tahun dan sebagian besar berjenis kelamin laki-laki (58%). Komorbiditas yang paling umum adalah DM (38%), dan kejadian iskemik terjadi pada 56% pasien. Lamanya PGK dan kejadian iskemia berkorelasi secara statistik signifikan (95% CI: 1,262–4,220; PRR: 2,308; p = 0,005). Pasien dengan PGK ≥ 6 bulan memiliki faktor risiko 2,3 kali lebih tinggi untuk mengalami kejadian iskemik dibandingkan dengan pasien dengan PGK < 6 bulan.References
Abe, S., Yoshizawa, M., Nakanishi, N., Yazawa, T., Yokota, K., Honda, M., & Sloman, G. (1996). Electrocardiographic abnormalities in patients receiving hemodialysis. American Heart Journal, 131(6), 1137-1144. https://doi.org/10.1016/S0002-8703(96)90088-5
Ahmadmehrabi, S., & Tang, W. H. W. (2018). Hemodialysis-induced cardiovascular disease. Seminars in dialysis, 31(3), 258–267. https://doi.org/10.1111/sdi.12694
Andhika, R., Afiatin, Supriyadi, R., Bandiara, R., Sukesi, L., Sudarmadi, A. P., Wahyudi, K., & Sofiatin, Y. (2025). One-year Survival of End-Stage Kidney Disease Patients Undergoing Hemodialysis in Indonesia. International journal of nephrology and renovascular disease, 18, 87–101. https://doi.org/10.2147/IJNRD.S508012
Arora, P. (2025). Chronic Kidney Disease (CKD). Medscape [serial online]. https://emedicine.medscape.com/article/238798-overview
Cabrera, C. S., Lee, A. S., Olsson, M., Schnecke, V., Westman, K., Lind, M., Greasley, P. J., & Skrtic, S. (2020). Impact of CKD Progression on Cardiovascular Disease Risk in a Contemporary UK Cohort of Individuals With Diabetes. Kidney international reports, 5(10), 1651–1660. https://doi.org/10.1016/j.ekir.2020.07.029
Chen, Y.T., Lin, C.C., Huang, P.H., Li, S.Y. (2024). Comparative analysis of hemodialysis and peritoneal dialysis on the risk of new onset diabetes mellitus. Journal of the Formosan Medical Association, 123(5), 606-612. https://doi.org/10.1016/j.jfma.2024.01.013
Chirakarnjanakorn, S., Navaneethan, S. D., Francis, G. S., & Tang, W. H. (2017). Cardiovascular impact in patients undergoing maintenance hemodialysis: Clinical management considerations. International journal of cardiology, 232, 12–23. https://doi.org/10.1016/j.ijcard.2017.01.015
Dewayani, R. (2007). Penyakit jantung koroner pada chronic kidney disease. Jurnal Kardiologi Indonesia, 28(5), 387-395.
Drechsler, C., Krane, V., Ritz, E., Marz, W., Wanner, C. (2009). Glycemic Control and Cardiovascular Events in Diabetic Hemodialysis Patients. AHA Circulation, 120(4), 2421-2428. https://doi.org/10.1161/CIRCULATIONAHA.109.857268
Echefu, G., Stowe, I., Burka, S., Basu-Ray, I., & Kumbala, D. (2023). Pathophysiological concepts and screening of cardiovascular disease in dialysis patients. Frontiers in nephrology, 3, 1198560. https://doi.org/10.3389/fneph.2023.1198560
Greig, D., Austin, P.C., Zhou, L., Tu, J.V., Pang, P.S., Ross, H.J., Lee, D.S. (2014). Ischemic Electrocardiographic Abnormalities and Prognosis in Decompensated Heart Failure. AHA Circulation: Heart Failure, 7(6), 986-993. https://doi.org/10.1161/CIRCHEARTFAILURE.114.001460
Hidayat, M., Motulo, F., Chandra, S., Andamari, S., Sulungbudi, J., Lesmana, R. (2023). Analysis of influencing factors in chronic kidney disease incidence in Indonesia. Indonesian Journal of Medicine and Health, 14(3), 296-305. https://doi.org/10.20885/JKKI.Vol14.Iss3.art10
Jankowski, J., Floege, J., Fliser, D., Bohm, M., Marx, N. (2021). Cardiovascular Disease in Chronic Kidney Disease: Pathophysiological Insights and Therapeutic Options. AHA Circulation, 143(11), 1157-1172. https://doi.org/10.1161/CIRCULATIONAHA.120.050686
Kovesdy, C. P. (2022). Epidemiology of chronic kidney disease: an update 2022. Kidney international supplements, 12(1), 7–11. https://doi.org/10.1016/j.kisu.2021.11.003
Levin, A., Ahmed, S.B., Carrero, J.J., Foster, B., Francis, A., Hall, R.K., … & Stevens, P.E. (2023). Executive summary of the KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease: known knowns and known unknowns. Kidney International, 105, 684-701. https://kdigo.org/wp-content/uploads/2017/02/KDIGO-2024-CKD-Guideline-Executive-Summary.pdf
Marx-Schutt, K., Cherney, D.Z.I., Jankowski, J., Matsushita, K., Nardone, M., Marx, N. (2025). Cardiovascular disease in chronic kidney disease. European Heart Journal, 46(23), 2148-2160. https://doi.org/10.1093/eurheartj/ehaf167
Mohamud, M.F.Y., Adan, F.N., Jeele, M.O.O., M., & Ahmed, M.A.M. (2023). Major cardiovascular events and associated factors among routine hemodialysis patients with end-stage renal disease at tertiary care hospital in Somalia. Frontiers in medicine, 10, 1086359. https://doi.org/10.3389/fmed.2023.1086359
Narula, A. S., Bali, H. S., Sakhuja, V., Chugh, K. S., & Oberoi, H. S. (1996). SILENT MYOCARDIAL ISCHEMIA IN HEMODIALYSIS PATIENTS - FACTOR FICTION?. Medical journal, Armed Forces India, 52(2), 110–112. https://doi.org/10.1016/S0377-1237(17)30855-9
Perone, F., Bernardi, M., Loguercio, M., Jacoangeli, F., Velardi, S., Metsovitis, T., Ramondinoe, F., Ruzzolini, M., Ambrosetti, M. (2025). Cardiovascular disease risk assessment, exercise training, and management of complications in patients with chronic kidney disease. International Journal of Cardiology Cardiovascular Risk and Prevention, 25, 200386. https://doi.org/10.1016/j.ijcrp.2025.200386
Ramatillah, D. L., Sulaiman, S. A. S., & Khan, K. U. (2020). Potential risk factors for mortality due to cardiovascular disease among hemodialysed patients in Indonesia. Pharmaceutical Sciences and Research, 7(2), 99-104. https://scholarhub.ui.ac.id/cgi/viewcontent.cgi?article=1096&context=psr
Shapira, O.M., & Bar-Khayim, Y. (1992). ECG Changes and Cardiac Arrhythmias in Chronic Renal Failure Patients on Hemodialysis. Journal of Electrocardiology, 25(4), 273-279. https://doi.org/10.1016/0022-0736(92)90032-U
Shroff, G. R., Li, S., & Herzog, C. A. (2015). Trends in Mortality Following Acute Myocardial Infarction Among Dialysis Patients in the United States Over 15 Years. Journal of the American Heart Association, 4(10), e002460. https://doi.org/10.1161/JAHA.115.002460
Susantitaphong, P., Koulouridis, I., Balk, E. M., Madias, N. E., & Jaber, B. L. (2012). Effect of frequent or extended hemodialysis on cardiovascular parameters: a meta-analysis. American journal of kidney diseases : the official journal of the National Kidney Foundation, 59(5), 689–699. https://doi.org/10.1053/j.ajkd.2011.12.020
Sy, S., Samaké, M., Coulibaly, M., Konaté, M., Diallo, D., Yat- tara, H., Fofana, A.S., Kodio, A., Sidibé, M., Coulibaly, N., Touré, A., Sy, D., Tangara, M. and Fongoro, S. (2020) Prevalence of Cardi- ovascular Risk Factors in Chronic Hemo- dialysis Patients at the University Hospital Center of Point G in Bamako, Mali. Open Journal of Nephrology, 10, 125-134. https://doi.org/10.4236/ojneph.2020.102013
Vallianou, N. G., Mitesh, S., Gkogkou, A., & Geladari, E. (2019). Chronic Kidney Disease and Cardiovascular Disease: Is there Any Relationship?. Current cardiology reviews, 15(1), 55–63. https://doi.org/10.2174/1573403X14666180711124825
Waks, J. W., Tereshchenko, L. G., & Parekh, R. S. (2016). Electrocardiographic predictors of mortality and sudden cardiac death in patients with end stage renal disease on hemodialysis. Journal of electrocardiology, 49(6), 848–854. https://doi.org/10.1016/j.jelectrocard.2016.07.020
Zannad, F., McGuire, D. K., & Ortiz, A. (2024). Treatment strategies to reduce cardiovascular risk in persons with chronic kidney disease and Type 2 diabetes. Journal of internal medicine, 297(5), 460–478. https://doi.org/10.1111/joim.20050
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Copyright (c) 2025 Faiz Agung Hermawan, Rebecca Rebecca, Muhammad Algifari Mufadhal Alwan, Mustika Mahbubi

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