NUTRISI SELAMA KEHAMILAN : PENGARUH TERHADAP MIKROBIOMA USUS DAN PERKEMBANGAN JANIN
DOI:
https://doi.org/10.31004/prepotif.v9i3.50380Keywords:
pregnancy nutrition, maternal gut microbiome, fetal developmentAbstract
Nutrisi selama kehamilan berperan penting dalam membentuk mikrobioma usus ibu, yang berdampak besar terhadap perkembangan janin. Asupan gizi seimbang tidak hanya mendukung kesehatan ibu, tetapi juga memengaruhi pertumbuhan dan fungsi organ janin melalui interaksi dengan mikrobioma. Penelitian ini bertujuan menelaah pengaruh nutrisi selama kehamilan terhadap mikrobioma usus dan perkembangan janin dengan pendekatan narrative review. Studi menunjukkan bahwa konsumsi makanan kaya serat, mikronutrien, serta probiotik dapat meningkatkan keberagaman mikrobioma dan produksi asam lemak rantai pendek (SCFA). Sebaliknya, pola makan tinggi lemak dan gula berisiko menimbulkan disbiosis. Mikrobioma maternal yang sehat berpotensi memberikan efek protektif jangka panjang terhadap berbagai gangguan kesehatan anak.References
Amiruddin, M., Sirih, M., & Irfandi. (2023). Hubungan pola makan dan gaya hidup dengan status gizi pada ibu hamil di wilayah kerja Puskesmas Poasia Kota Kendari. Jurnal Kesehatan Masyarakat.
Barrientos, G., Ronchi, F., & Conrad, M. L. (2024). Nutrition during pregnancy: Influence on the gut microbiome and fetal development. American Journal of Reproductive Immunology.
Basak, S., Mallick, R., Sree, B. N., & Duttaroy, A. K. (2024). Placental epigenome impacts fetal development: Effects of maternal nutrients and gut microbiota. Nutrients.
Cortés-Albornoz, M. C., García-Guáqueta, D. P., Velez-Van-Meerbeke, A., & Talero-Gutiérrez, C. (2021). Maternal nutrition and neurodevelopment: A scoping review. Nutrients.
Deng, L., Taelman, S., Olm, M. R., Lebreton, F., Chng, K. R., Almeida, A., et al. (2025). Maternal balanced energy-protein supplementation reshapes the maternal gut microbiome and enhances carbohydrate metabolism in infants: A randomized controlled trial. Nature Communications.
Dreisbach, C., Prescott, S., Siega-Riz, A. M., Tang, W. Y., Ramakrishnan, U., & Thompson, A. L. (2023). Composition of the maternal gastrointestinal microbiome as a predictor of neonatal birth weight. Pediatric Research.
Faienza, M. F., Urbano, F., Anaclerio, F., Moretti-Ferreira, D., Fico, D., Scagliusi, F. B., et al. (2024). Exploring maternal diet-epigenetic-gut microbiome crosstalk as an intervention strategy to counter early obesity programming. Current Issues in Molecular Biology.
Gray, L. E. K., O’Hely, M., Ranganathan, S., Sly, P. D., & Vuillermin, P. (2017). The maternal diet, gut bacteria, and bacterial metabolites during pregnancy influence offspring asthma. Frontiers in Immunology.
Hasebe, K., Kendig, M. D., Kaakoush, N. O., Fiebiger, E., Loke, P., Cowley, M. A., et al. (2025). Pregnancy-related changes in microbiome are disrupted by obesogenic diet exposure: Implications for offspring microbiome development. Food & Function.
Kementerian Kesehatan RI. (2022). Laporan kinerja Kementerian Kesehatan Republik Indonesia.
Kunasegaran, T., Balasubramaniam, V. R. M. T., Arasoo, V. J. T., Palanisamy, U. D., & Ramadas, A. (2023). Diet-gut microbiota axis in pregnancy: A systematic review of recent evidence. Current Nutrition Reports.
Kusuma Dewi, A., & Tampubolon, R. (2023). Status gizi dan perilaku makan ibu selama kehamilan trimester pertama. Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Kristen Satya Wacana.
Lopez-Tello, J., Kiu, R., Schofield, Z., Anthony, D., Ralser, M., Lawley, T. D., et al. (2024). Maternal gut Bifidobacterium breve modifies fetal brain metabolism in germ-free mice. Molecular Metabolism.
Lundgren, S. N., Madan, J. C., Emond, J. A., Morrison, H. G., Christensen, B. C., & Karagas, M. R. (2018). Maternal diet during pregnancy is related with the infant stool microbiome in a delivery mode-dependent manner. Microbiome.
Maher, S. E., O’Brien, E. C., Moore, R. L., Byrne, D. F., Geraghty, A. A., & McCarthy, F. P. (2023). The association between the maternal diet and the maternal and infant gut microbiome: A systematic review. British Journal of Nutrition.
Miko, E., Csaszar, A., Bodis, J., & Kovacs, K. (2022). The maternal–fetal gut microbiota axis: Physiological changes, dietary influence, and modulation possibilities. Life (Basel).
Program DIII Kebidanan, STIKes Panca Bhakti Bandar Lampung. (2022). Pengetahuan ibu hamil tentang kebutuhan nutrisi selama kehamilan. Jurnal Kesehatan, 3.
Puglisi, C. H., Kim, M., Aldhafeeri, M., Lewandowski, M., & Vuong, H. E. (2025). Interactions of the maternal microbiome with diet, stress, and infection influence fetal development. FEBS Journal.
Sajdel-Sulkowska, E. M. (2023). The impact of maternal gut microbiota during pregnancy on fetal gut–brain axis development and life-long health outcomes. Microorganisms.
Soekmawaty, R. A., Setyawati, I., & Utami, K. (2022). Peningkatan pengetahuan tentang kebutuhan nutrisi pada ibu hamil. Jurnal Kesehatan, 1.
Strobel, K. M., Juul, S. E., & Hendrixson, D. T. (2023). Maternal nutritional status and the microbiome across the pregnancy and the post-partum period. Microorganisms.
Taylor, R., Keane, D., Borrego, P., & Arcaro, K. (2023). Effect of maternal diet on maternal milk and breastfed infant gut microbiomes: A scoping review. Nutrients.
Zaidi, A. Z., Moore, S. E., & Okala, S. G. (2021). Impact of maternal nutritional supplementation during pregnancy and lactation on the infant gut or breastmilk microbiota: A systematic review. Nutrients.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Qaniah Mardiyah Akil, Mona Nulanda, Johnsen Mailoa

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work’s authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal’s published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).







