KARAKTERISTIK PENDERITA PERITONITIS ET CAUSA APENDISITIS PERFORASI : LITERATURE REVIEW

Authors

  • Afdhal Qalam Hidayah Amir Profesi Dokter, Fakultas Kedokteran, Universitas Muslim Indonesia, Indonesia
  • Azis Beru Gani Departemen Bedah Umum, Universitas Muslim Indonesia, RS Ibnu Sina
  • Erwin Syarifuddin Departemen Bedah Digestive, Universitas Muslim Indonesia, RS Bhayangkara

DOI:

https://doi.org/10.31004/prepotif.v9i3.50273

Keywords:

apendisitis perforasi, karakteristik pasien, non-operative management, peritonitis

Abstract

Peritonitis akibat apendisitis perforasi merupakan salah satu kondisi gawat darurat abdomen yang sering dijumpai dan berpotensi menimbulkan komplikasi serius. Penatalaksanaan standar umumnya berupa tindakan operatif, namun dalam beberapa dekade terakhir, pendekatan non-operative management (NOM) mulai dipertimbangkan sebagai alternatif terapi pada pasien terpilih. Penelitian ini merupakan sebuah systematic literature review yang dilakukan secara sistematis untuk mengidentifikasi, menyaring, dan menganalisis artikel yang relevan melalui beberapa basis data elektronik, yaitu PubMed, ScienceDirect, Google Scholar, ResearchGate, dan ClinicalKey. Hasil kajian menunjukkan bahwa karakteristik pasien peritonitis akibat apendisitis perforasi yang paling sering ditemukan adalah usia muda hingga dewasa awal, dominan laki-laki, kondisi hemodinamik stabil, tanpa komorbiditas signifikan, serta disertai abses lokal atau massa apendikularis. Sebaliknya, pasien dengan usia lanjut, adanya sepsis, peritonitis difus, dan komorbiditas berat cenderung memiliki luaran klinis yang lebih buruk. Kesimpulannya, faktor usia, jenis kelamin, status klinis, dan komorbiditas merupakan hal penting yang perlu diperhatikan dalam menilai risiko dan menentukan prognosis pasien dengan peritonitis akibat apendisitis perforasi.

References

Agaoglu, N., & Ulusahin, M. (2017). Non-operative treatment of acute appendicitis in selected patients. International Surgery Journal, 4(10), 3190.

Andersson, R. E. (2013). The role of antibiotic therapy in the management of acute appendicitis. Current Infectious Disease Reports, 15(1), 10–13.

Andersson, R. E., & Petzold, M. G. (2007). Nonsurgical treatment of appendiceal abscess or phlegmon. Annals of Surgery, 246(5), 741–748.

Austin, H. K., & McGuirt, A. S. (2024, October 10). Balancing a surgical vs. non-surgical approach in perforated appendicitis. Cureus.

Balogun, O., Osinowo, A., Afolayan, M., Olajide, T., Lawal, A., & Adesanya, A. (2019). Acute perforated appendicitis in adults: Management and complications in Lagos, Nigeria. Annals of African Medicine, 18(1), 36.

Bhangu, A., Søreide, K., Di Saverio, S., Assarsson, J. H., & Drake, F. T. (2015). Acute appendicitis: Modern understanding of pathogenesis, diagnosis, and management. The Lancet, 386(10000), 1278–1287.

Constantin, M., Petrescu, L., Mătanie, C., Vrancianu, C. O., Niculescu, A. G., Andronic, O., et al. (2023). The vermiform appendix and its pathologies. Cancers (Basel), 15(15), 3872.

Dagne, H., & Abebaw, T. A. (2022). Characteristics of patients presented with complicated appendicitis in Adama, Ethiopia: A cross-sectional study. Open Access Emergency Medicine, 14, 573–580.

Dahiya, D. S., Akram, H., Goyal, A., Khan, A. M., Shahnoor, S., Hassan, K. M., et al. (2024). Controversies and future directions in management of acute appendicitis: An updated comprehensive review. Journal of Clinical Medicine, 13(11), 3034.

Di Saverio, S., Podda, M., De Simone, B., Ceresoli, M., Augustin, G., Gori, A., et al. (2020). Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines. World Journal of Emergency Surgery, 15(1), 27.

Hall, N. J., Eaton, S., Sherratt, F. C., Reading, I., Walker, E., Chorozoglou, M., et al. (2021). Conservative treatment of appendicitis in children: A randomised controlled feasibility trial (CONTRACT). Archives of Disease in Childhood, 106(8), 764–773.

Helling, T. S., Soltys, D. F., & Seals, S. (2017). Operative versus non-operative management in the care of patients with complicated appendicitis. The American Journal of Surgery, 214(6), 1195–1200.

Howell, E. C., Dubina, E. D., & Lee, S. L. (2018). Perforation risk in pediatric appendicitis: Assessment and management. Pediatric Health, Medicine and Therapeutics, 9, 135–145.

Jacob, D., Le, L., & Silverstone, L. (2008). Acute appendicitis. In: Radiopaedia.org. Retrieved from https://radiopaedia.org

Jumah, S., & Wester, T. (2022). Non-operative management of acute appendicitis in children. Pediatric Surgery International, 39(1), 11.

Kidwai, R., & Sharma, A. (2018). Acute perforated appendicitis: Clinical profile and analysis of risk factors. Journal of Nepalgunj Medical College, 16(2), 13–15.

Lamm, R., Kumar, S. S., Collings, A. T., Haskins, I. N., Abou-Setta, A., Narula, N., et al. (2023). Diagnosis and treatment of appendicitis: Systematic review and meta-analysis. Surgical Endoscopy, 37(12), 8933–8990.

Lee, H. G., & Park, I. J. (2025). Clinical outcomes and optimal indications for nonoperative management of acute appendicitis in adult patients: A comprehensive literature review. Annals of Coloproctology, 41(2), 107–118.

Lotfollahzadeh, S., Lopez, R. A., & Deppen, J. G. (2025). Appendicitis [Internet]. Treasure Island (FL): StatPearls Publishing. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK493193/

Marin, D., Ho, L. M., Barnhart, H., Neville, A. M., White, R. R., & Paulson, E. K. (2010). Percutaneous abscess drainage in patients with perforated acute appendicitis: Effectiveness, safety, and prediction of outcome. American Journal of Roentgenology, 194(2), 422–429.

Maxfield, M. W., Schuster, K. M., Bokhari, J., McGillicuddy, E. A., & Davis, K. A. (2014). Predictive factors for failure of nonoperative management in perforated appendicitis. Journal of Trauma and Acute Care Surgery, 76(4), 976–981.

Moris, D., Paulson, E. K., & Pappas, T. N. (2021). Diagnosis and management of acute appendicitis in adults. JAMA, 326(22), 2299.

Nepomuceno, H., & Pearson, E. G. (2021). Nonoperative management of appendicitis in children. Translational Gastroenterology and Hepatology, 6, 47.

Sartelli, M., Catena, F., Abu-Zidan, F. M., Ansaloni, L., Biffl, W. L., Boermeester, M. A., et al. (2017). Management of intra-abdominal infections: Recommendations by the WSES 2016 consensus conference. World Journal of Emergency Surgery, 12(1), 22.

Simillis, C., Symeonides, P., Shorthouse, A. J., & Tekkis, P. P. (2010). A meta-analysis comparing conservative treatment versus acute appendectomy for complicated appendicitis (abscess or phlegmon). Surgery, 147(6), 818–829.

Vos, T., Allen, C., Arora, M., Barber, R. M., Bhutta, Z. A., Brown, A., et al. (2016). Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: A systematic analysis for the Global Burden of Disease Study 2015. The Lancet, 388(10053), 1545–1602.

Wakasa, Y., Toyoki, Y., Kameyama, Y., Odagiri, T., Jin, H., Nakai, M., et al. (2023). Predictors of nonoperative management failure and recurrence in adults with acute appendicitis: A single-center retrospective study. Surgery, Gastroenterology and Oncology, 28(2), 79.

Watanabe, R., Otsuji, A., Nakamura, Y., Higuchi, T., Takahashi, A., Saito, T., et al. (2020). Superior outcomes (but at higher costs) of non‐operative management with interval appendectomy over immediate surgery in appendicitis with abscess: Results from a large adult population cohort. Asian Journal of Endoscopic Surgery, 13(2), 186–194.

Zhou, S., Cheng, Y., Cheng, N., Gong, J., & Tu, B. (2024). Early versus delayed appendicectomy for appendiceal phlegmon or abscess. Cochrane Database of Systematic Reviews, 2024(5).

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Published

2025-10-14

How to Cite

Amir, A. Q. H., Gani, A. B., & Syarifuddin, E. (2025). KARAKTERISTIK PENDERITA PERITONITIS ET CAUSA APENDISITIS PERFORASI : LITERATURE REVIEW. PREPOTIF : JURNAL KESEHATAN MASYARAKAT, 9(3), 7216–7228. https://doi.org/10.31004/prepotif.v9i3.50273