PENGARUH INFEKSI SARS-COV-2 TERHADAP ANGKA MORTALITAS DAN READMISI PADA PASIEN GAGAL JANTUNG DALAM 1 TAHUN FOLLOW-UP DI RS PKU MUHAMMADIYAH GAMPING YOGYAKARTA
DOI:
https://doi.org/10.31004/prepotif.v9i3.49087Keywords:
SARS-CoV-2, COVID-19, Mortalitas, Readmisi, Gagal JantungAbstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) adalah virus korona baru yang menyebar dengan cepat. Infeksi pada pasien dengan riwayat gagal jantung berkaitan dengan prognosis yang buruk. Namun, pengaruh infeksi SARS-CoV-2 terhadap efek jangka panjang pasien gagal jantung masih belum sepenuhnya diketahui. Penelitian ini bertujuan untuk mengetahui pengaruh infeksi SARS-CoV-2 terhadap angka mortalitas dan readmisi pada pasien gagal jantung dalam 1 tahun follow-up di RS PKU Muhammadiyah Gamping Yogyakarta. Penelitian ini menggunakan metode kuantitatif dengan desain kohort retrospektif dan menggunakan data rekam medis pasien gagal jantung pada tahun 2020 sampai dengan 2022 di RS PKU Muhammadiyah Gamping Yogyakarta. Pasien dibagi menjadi dua kelompok, yaitu pasien gagal jantung yang terinfeksi SARS-CoV-2 dan tidak terinfeksi SARS-CoV-2. Luaran penelitian berupa angka mortalitas dan readmisi dalam 1 tahun follow-up. Didapatkan 230 pasien gagal jantung yang dirawat di RS PKU Muhammadiyah Gamping Yogyakarta pada 1 Januari 2020 sampai 31 Desember 2022 dengan 70 di antaranya terinfeksi SARS-CoV-2. Kelompok pasien gagal jantung dengan riwayat infeksi SARS-CoV-2 memiliki angka mortalitas dalam 1 tahun follow-up yang lebih tinggi (RR 4.35, 95% CI 1.91-9.87, p < 0.001), tetapi tidak memengaruhi angka readmisi (p > 0.05) dalam 1 tahun follow-up. Infeksi SARS-CoV-2 meningkatkan angka mortalitas pasien gagal jantung dalam 1 tahun follow-up, tetapi tidak memengaruhi angka readmisi pasien gagal jantung dalam 1 tahun follow up di RS PKU Muhammadiyah Gamping Yogyakarta.References
Al-Tamimi, M. A.-A., Gillani, S. W., Abd Alhakam, M. E., & Sam, K. G. (2021). Factors Associated with Hospital Readmission of Heart Failure Patients. Frontiers in Pharmacology, 12. https://doi.org/10.3389/fphar.2021.732760
Auron, M., Porres-Aguilar, M., & Cameron, S. J. (2022). COVID-19 and Elevated D-Dimer: A Tale of Caution. Journal of General Internal Medicine, 37(5), 1304–1305. https://doi.org/10.1007/s11606-021-07280-9
Ayalon‐Dangur, I., Rudman, Y., Shochat, T., Shiber, S., & Grossman, A. (2018). Elevated blood pressure during emergency departments visit is associated with increased rate of hospitalization for heart failure: A retrospective cohort study. The Journal of Clinical Hypertension, 20(1), 98–103. https://doi.org/10.1111/jch.13155
Bansal, N., Zelnick, L., Bhat, Z., Dobre, M., He, J., Lash, J., Jaar, B., Mehta, R., Raj, D., Rincon-Choles, H., Saunders, M., Schrauben, S., Weir, M., Wright, J., Go, A. S., Appel, L. J., Feldman, H. I., Go, A. S., He, J., … Townsend, R. R. (2019). Burden and Outcomes of Heart Failure Hospitalizations in Adults With Chronic Kidney Disease. Journal of the American College of Cardiology, 73(21), 2691–2700. https://doi.org/10.1016/j.jacc.2019.02.071
Bhopalwala, H., Akbar, A., Dewaswala, N., Wisnieski, L., Minhas, A. M. K., Hussain, A., Mishra, V., Dani, S. S., Kolodziej, A., Vaidya, G., Kulkarni, A., Piercy, J., Ganti, S., Moka, N., & Bhopalwala, A. (2022). Outcomes of Heart Failure in COVID-19 Patients: An Appalachian Experience. Cardiology Research, 13(3), 162–171. https://doi.org/10.14740/cr1389
Clerkin, K. J., Fried, J. A., Raikhelkar, J., Sayer, G., Griffin, J. M., Masoumi, A., Jain, S. S., Burkhoff, D., Kumaraiah, D., Rabbani, L. R., Schwartz, A., & Uriel, N. (2020). COVID-19 and Cardiovascular Disease. Circulation, 141(20), 1648–1655. https://doi.org/10.1161/CIRCULATIONAHA.120.046941
de Lusignan, S., Dorward, J., Correa, A., Jones, N., Akinyemi, O., Amirthalingam, G., Andrews, N., Byford, R., Dabrera, G., Elliot, A., Ellis, J., Ferreira, F., Lopez Bernal, J., Okusi, C., Ramsay, M., Sherlock, J., Smith, G., Williams, J., Howsam, G., … Hobbs, F. D. R. (2020). Risk factors for SARS-CoV-2 among patients in the Oxford Royal College of General Practitioners Research and Surveillance Centre primary care network: a cross-sectional study. The Lancet Infectious Diseases, 20(9), 1034–1042. https://doi.org/10.1016/S1473-3099(20)30371-6
Giakoumis, M., Sargsyan, D., Kostis, J. B., Cabrera, J., Dalwadi, S., & Kostis, W. J. (2020). Readmission and mortality among heart failure patients with history of hypertension in a statewide database. The Journal of Clinical Hypertension, 22(7), 1263–1274. https://doi.org/10.1111/jch.13918
Groenewegen, A., Rutten, F. H., Mosterd, A., & Hoes, A. W. (2020). Epidemiology of Heart Failure. Dalam European Journal of Heart Failure (Vol. 22, Nomor 8, hlm. 1342–1356). John Wiley and Sons Ltd. https://doi.org/10.1002/ejhf.1858
Huang, X., Liu, J., Zhang, L., Wang, B., Bai, X., Hu, S., Miao, F., Tian, A., Yang, T., Li, Y., & Li, J. (2022). Systolic Blood Pressure and 1-Year Clinical Outcomes in Patients Hospitalized for Heart Failure. Frontiers in Cardiovascular Medicine, 9. https://doi.org/10.3389/fcvm.2022.877293
Khoshdel-Rad, N., Zahmatkesh, E., Shpichka, A., Timashev, P., & Vosough, M. (2021). Outbreak of chronic renal failure: will this be a delayed heritage of COVID-19? Journal of Nephrology, 34(1), 3–5. https://doi.org/10.1007/s40620-020-00851-9
Lee, S., Lim, K. R., Chun, K. J., & Kim, B. S. (2024). Long-term impacts of COVID-19 in patients with prior heart failure in Korea: A nationwide cohort study using the common data model. Medicine, 103(31), e39236. https://doi.org/10.1097/MD.0000000000039236
Levy, D. (1996). The Progression From Hypertension to Congestive Heart Failure. JAMA: The Journal of the American Medical Association, 275(20), 1557. https://doi.org/10.1001/jama.1996.03530440037034
Lindmark, K., Boman, K., Olofsson, M., Törnblom, M., Levine, A., Castelo-Branco, A., Schlienger, R., Wirta, S. B., Stålhammar, J., & Wikström, G. (2019). Epidemiology of Heart Failure and Trends in Diagnostic Work-Up: A Retrospective, Population-Based Cohort Study in Sweden. Clinical Epidemiology, 11, 231–244. https://doi.org/10.2147/CLEP.S170873
Mueller, C., Giannitsis, E., Jaffe, A. S., Huber, K., Mair, J., Cullen, L., Hammarsten, O., Mills, N. L., Möckel, M., Krychtiuk, K., Thygesen, K., & Lindahl, B. (2021). Cardiovascular biomarkers in patients with COVID-19. European Heart Journal. Acute Cardiovascular Care, 10(3), 310–319. https://doi.org/10.1093/ehjacc/zuab009
Mukkawar, R. V, Reddy, H., Rathod, N., Kumar, S., & Acharya, S. (2024). The Long-Term Cardiovascular Impact of COVID-19: Pathophysiology, Clinical Manifestations, and Management. Cureus. https://doi.org/10.7759/cureus.66554
Nicin, L., Abplanalp, W. T., Mellentin, H., Kattih, B., Tombor, L., John, D., Schmitto, J. D., Heineke, J., Emrich, F., Arsalan, M., Holubec, T., Walther, T., Zeiher, A. M., & Dimmeler, S. (2020). Cell Type-Specific Expression of the Putative SARS-CoV-2 Receptor ACE2 in Human Hearts. European Heart Journal, 41(19), 1804–1806. https://doi.org/10.1093/eurheartj/ehaa311
Santner, V., Riepl, H. S., Posch, F., Wallner, M., Rainer, P. P., Ablasser, K., Kolesnik, E., Hoeller, V., Zach, D., Schwegel, N., Kreuzer, P., Lueger, A., Petutschnigg, J., Pieske, B., Zirlik, A., Edelmann, F., & Verheyen, N. (2023). Non-eligibility for pivotal HFpEF/HFmrEF outcome trials and mortality in a contemporary heart failure cohort. European Journal of Internal Medicine, 118, 73–81. https://doi.org/10.1016/j.ejim.2023.07.027
Sebbar, E., & Choukri, M. (2023). Cardiovascular markers and COVID-19. Materials Today: Proceedings, 72, 3356–3359. https://doi.org/10.1016/j.matpr.2022.07.388
Susilo, A., Jasirwan, C. O. M., Wafa, S., Maria, S., Rajabto, W., Muradi, A., Fachriza, I., Putri, M. Z., & Gabriella, S. (2022). Mutasi dan Varian Coronavirus Disease 2019 (COVID-19): Tinjauan Literatur Terkini. Jurnal Penyakit Dalam Indonesia, 9(1), 59. https://doi.org/10.7454/jpdi.v9i1.648
Yang, X., Yu, Y., Xu, J., Shu, H., Xia, J., Liu, H., Wu, Y., Zhang, L., Yu, Z., Fang, M., Yu, T., Wang, Y., Pan, S., Zou, X., Yuan, S., & Shang, Y. (2020). Clinical Course and Outcomes of Critically Ill Patients with SARS-CoV-2 Pneumonia in Wuhan, China: A Single-Centered, Retrospective, Observational Study. The Lancet Respiratory Medicine, 8(5), 475–481. https://doi.org/10.1016/S2213-2600(20)30079-5
Zaim, S., Chong, J. H., Sankaranarayanan, V., & Harky, A. (2020). COVID-19 and Multiorgan Response. Dalam Current Problems in Cardiology (Vol. 45, Nomor 8). Mosby Inc. https://doi.org/10.1016/j.cpcardiol.2020.100618
Zhou, F., Yu, T., Du, R., Fan, G., Liu, Y., Liu, Z., Xiang, J., Wang, Y., Song, B., Gu, X., Guan, L., Wei, Y., Li, H., Wu, X., Xu, J., Tu, S., Zhang, Y., Chen, H., & Cao, B. (2020). Clinical Course and Risk Factors for Mortality of Adult Inpatients with COVID-19 in Wuhan, China: A Retrospective Cohort Study. The Lancet, 395(10229), 1054–1062. https://doi.org/10.1016/S0140-6736(20)30566-3
Zhou, P., Yang, X. Lou, Wang, X. G., Hu, B., Zhang, L., Zhang, W., Si, H. R., Zhu, Y., Li, B., Huang, C. L., Chen, H. D., Chen, J., Luo, Y., Guo, H., Jiang, R. Di, Liu, M. Q., Chen, Y., Shen, X. R., Wang, X., … Shi, Z. L. (2020). A Pneumonia Outbreak Associated with a New Coronavirus of Probable Bat Origin. Nature, 579(7798), 270–273. https://doi.org/10.1038/s41586-020-2012-7
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Aufa Zidan Hibatulloh, Gagah Buana Putra
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work’s authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal’s published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
