PENDEKATAN DIAGNOSIS DAN PENATALAKSANAAN CRUSTED SCABIES PADA PASIEN IMUNOSUPRESI
DOI:
https://doi.org/10.31004/prepotif.v9i2.48367Keywords:
Skabies Berkrusta, Skabies norwegia, Imunosupresi, Diabetes mellitusAbstract
Menurut perkiraan WHO, skabies mempengaruhi lebih dari 200 juta individu diseluruh dunia pada satu waktu. Meskipun skabies dapat dicegah dan diobati, penyakit ini mempengaruhi lebih dari 130 juta orang di seluruh dunia pada suatu waktu, yang menyebabkan lebih dari 1,5 juta tahun hidup dengan disabilitas di seluruh dunia. Indonesia memiliki beban skabies tertinggi di antara 195 negara yang diinvestigasi, dengan Disability Adjusted Life Year (DALYs) yang distandarisasi berdasarkan usia sebesar 153,86 per 100.000 penduduk. Crusted scabies merupakan bentuk skabies yang berat dan sangat menular. Penyakit ini terutama menyerang individu dengan sistem kekebalan tubuh yang lemah, diabetes melitus menjadi faktor predisposisi yang signifikan. Namun penyakit ini seringkali menyerupai kondisi dermatologis lain seperti psoriasis, yang menyebabkan keterlambatan diagnosis dan pengobatan yang tidak tepat. Kami melaporkan sebuah kasus crusted scabies dengan infeksi sekunder pada wanita 48 tahun yang memiliki riwayat diabetes mellitus tidak terkontrol. Pasien mengeluhkan terdapat banyak bintik kemerahan dan bercak kehitaman pada seluruh tubuh kecuali area wajah sejak 2 bulan lalu yang memberat 3 minggu terakhir hingga disertai sisik tebal berwarna putih kekuningan. Status gizi pasien termasuk gemuk tingkat berat berdasarkan klasifikasi Kemenkes RI. Pasien dirawat secara holistik bersama dengan spesialis penyakit dalam untuk mengontrol kondisi hiperglikemik yang dialami.References
Berbudi, A., Rahmadika, N., Tjahjadi, A.I., Ruslami, R. (2020). Type 2 diabetes and its impact on the immune system. Curr Diabetes Rev, 16(5), 442–9.
Bergamin, G., Hudson, J., Currie, B. J., & Mounsey, K. E. (2024). A systematic review of immunosuppressive risk factors and comorbidities associated with the development of crusted scabies. International Journal of Infectious Diseases, 143, 1-9. Article 107036. https://doi.org/10.1016/j.ijid.2024.107036
Centers for Disease Control and Prevention. (2024). About Scabies. CDC [serial online]. https://www.cdc.gov/scabies/about/index.html?CDC_AAref_Val=https://www.cdc.gov/parasites/scabies/health_professionals/control.html
Centers for Disease Control and Prevention. (2023a). Clinical Overview of Crusted Scabies. CDC [serial online]. https://www.cdc.gov/scabies/hcp/clinical-overview/index.html#cdc_generic_section_1-overview
Centers for Disease Control and Prevention. (2023b). Clinical Care of Scabies. CDC [serial online]. https://www.cdc.gov/scabies/hcp/clinical-care/index.html
Centers for Disease Control and Prevention. (2023c). Public Health Strategies for Crusted Scabies Outbreaks in Institutional Settings. CDC [serial online]. https://www.cdc.gov/scabies/php/public-health-strategy-crusted/?CDC_AAref_Val=https://www.cdc.gov/parasites/scabies/health_professionals/crusted.html
Chiu, S., & Argaez, C. (2019). Ivermectin for Parasitic Skin Infections of Scabies: A Review of Comparative Clinical Effectiveness, Cost-Effectiveness, and Guidelines [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health. https://www.ncbi.nlm.nih.gov/books/NBK545083/
Fauzah, R., & Suparmi, S. (2023). Analysis of the Scabies Incidence at As'ad Islamic Boarding School, Jambi City. Archives of Razi Institute, 78(6), 1719–1727. https://doi.org/10.32592/ARI.2023.78.6.1719
Furuya, K., Nakajima, H., Sasaki, Y., Ishiko, A., & Urita, Y. (2016). A scabies outbreak in a diabetic and collagen disease ward: Management and prevention. Experimental and therapeutic medicine, 12(6), 3711–3715. https://doi.org/10.3892/etm.2016.3845
Gupta, S., Thornley, S., Morris, A., Sundborn, G., Grant, C. (2025). Global trends and prevalence of scabies: a spatiotemporal analysis using Global Burden of Disease 2021 data. MedRxiv. https://doi.org/10.1101/2025.01.24.25321000
Jafar, N., Edriss, H., & Nugent, K. (2016). The Effect of Short-Term Hyperglycemia on the Innate Immune System. The American journal of the medical sciences, 351(2), 201–211. https://doi.org/10.1016/j.amjms.2015.11.011
Jouret, G., Bounemeur, R., Presle, A., & Takin, R. (2016). La gale hyperkératosique [Crusted scabies: A review]. Annales de dermatology et de venereologie, 143(4), 251–256. https://doi.org/10.1016/j.annder.2016.02.001
Karimkhani, C., Colombara, D.V., Drucker, A.M., Norton, S.A., Hay, R., Engelman, D., … & Dellavalle, R.P. (2017). The global burden of scabies: a cross-sectional analysis from the Global Burden of Disease Study 2015. Lancet Infection Disease. https://www.paho.org/sites/default/files/2018-cde-global-burden-scabies-analysis.pdf
Li, J., Liu, Z., & Xia, X. (2024). The disability-adjusted life years (DALYs), prevalence and incidence of scabies, 1990–2021: A systematic analysis from the Global Burden of Disease Study 2021. PLos Neglected Tropical Diseases, 18(12). https://doi.org/10.1371/journal.pntd.0012775
Loewy, M.A. (2025). Scabies on the Rise Worldwide, Even in High-Income Countries. Medscape Medical News [serial online]. https://www.medscape.com/viewarticle/scabies-rise-worldwide-even-high-income-countries-2025a1000ccw
Maharani, C.S., Harnanti, D.V., Mappamasing, H., Widyantari, S., Sawitri, S., Ervianty, E., … & Listiawan, M.Y. (2019). Crusted scabies in patients with long-term use of oral corticosteroids with different underlying diseases – case series. 23rd Regional Conference of Dermatology, 11(1). https://doi.org/10.4081/dr.2019.8095
Niode, N. J., Adji, A., Gazpers, S., Kandou, R. T., Pandaleke, H., Trisnowati, D. M., … & Tallei, T. E. (2022). Crusted Scabies, a Neglected Tropical Disease: Case Series and Literature Review. Infectious disease reports, 14(3), 479–491. https://doi.org/10.3390/idr14030051
Palaniappan, V., Gopinath, H., & Kaliaperumal, K. (2021). Crusted Scabies. The American Journal of Tropical Medicine and Hygiene, 104(3), 787-788. https://doi.org/10.4269/ajtmh.20-1334
Putranti, I.O., Suryani, L.K., Safitri, L.A. (2024). Prevalence, severity of scabies, and relationship between gender and education level with scabies disease at Islamic Boarding School X Wonosobo. Jurnal eduHealth, 15(1), 339-344. https://ejournal.seaninstitute.or.id/index.php/healt
Rahmawati, N.A., Chomariyati, A., Mudjanarko, S.W. (2022). A Fatal Case of Norwegian Scabies in a Patinet With Diabetes Mellitus. Bali Medical Journal, 11(2), 870-874. https://doi.org/10.15562/bmj.v11i2.3500
Salavastru, C. M., Chosidow, O., Boffa, M. J., Janier, M., & Tiplica, G. S. (2017). European guidelines for the management of scabies. Journal of the European Academy of Dermatology and Venereology: JEADV, 31(8), 1248–1253. https://doi.org/10.1111/jdv.14351
Soto, J. M. M., Alvarado Motte, R. A., Ramírez Carrillo, P., Meraz Soto, A. A., Bayón Villaseñor, V., & Cheirif Wolosky, O. (2023). Crusted Hyperkeratotic Scabies: A Case Report. Cureus, 15(2), e34520. https://doi.org/10.7759/cureus.34520
Thomas, L. (2021). Crusted Scabies. DermNet [serial online]. https://dermnetnz.org/topics/crusted-scabies
Trasia, R.F. (2023). Review of Scabies: Current Update of Pathogenesis, Transmission, and Elimination. Jurnal Ilmu Medis Indonesia (JIMI), 3(1), 41-46. https://doi.org/10.35912/jimi.v3i1.2417
Trisadi, S., Basuki, S., Rofiq, A., Anshory, M. (2023). Successful combination therapy of permethrin 5% cream and oral ivermectin in crusted scabies patients. World Journal of Advanced Research and Reviews, 19(1), 1197-1201. https://doi.org/10.30574/wjarr.2023.19.1.1505
Verma, R., Arora, V.K., Kalra, S., Kumar, A., Srivastava, A., Jindal, B. (2022). Rare Form of Crusted Scabirs in Diabetes: A Case Report. Indian Journal of Clinical Practice, 32(9), 34-37. https://ijcp.in/Admin/CMS/PDF/9.%20CaseReport3_IJCP_Feb2022.pdf
Wang, A. (2020). Diabetes Increases Risk of Some Dermatologic Conditions. Pharmacy Times [serial online], 88 (7). https://www.pharmacytimes.com/view/diabetes-increases-risk-of-some-dermatologic-conditions
Wang, Y., Liu, Y., & Long, F. Q. (2021). Crusted scabies mimicking psoriasis in a patient with type 1 diabetes mellitus. Anais brasileiros de dermatology, 96(3), 385–386. https://doi.org/10.1016/j.abd.2020.06.020
Widaty, S., Salavastru, C., Oktarina, C. (2024). Skin Infestations in the Diabetic Patient: Scabies. Springer Nature, 101-108. https://doi.org/10.1007/978-3-031-65300-1_10
World Health Organization. (2023). Scabies. WHO [serial online]. https://www.who.int/news-room/fact-sheets/detail/scabies
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Nida Maulida, Novia Yudhitiara, Hari Darmawan

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work’s authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal’s published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).







