NON-ARTERITIC ANTERIOR ISCHEMIC OPTIC NEUROPATHY IN SMOKER ADULTS

Authors

  • Nur Anisa Candra Kirana Bachelor of Med, Faculty of Medicine, Tarumanagara University, Jakarta, Indonesia
  • Hayati Hayati Department of Ophthalmology, Bhayangkara Hospital, Semarang, Indonesia

DOI:

https://doi.org/10.31004/prepotif.v9i2.47968

Keywords:

Non-Arteritic Anterior Ischemic Optic Neuropathy, Smoker, NAION-related smoker, Adult

Abstract

Neuropati optik iskemik anterior non-arteritik (NAION) dikenal sebagai neuropati optik akut yang paling umum dan penyebab utama kehilangan penglihatan mendadak tanpa rasa sakit di seluruh dunia, dengan perkiraan kejadian tahunan berkisar antara 2,3 hingga 10,2 per 100.000 individu >50 tahun. Meskipun asal pasti NAION masih belum diketahui, patofisiologinya melibatkan infark iskemik kepala saraf optik karena aliran darah yang terganggu melalui arteri siliaris posterior pendek, dengan beberapa faktor risiko vaskular sistemik yang berkontribusi terhadap perkembangannya termasuk peran merokok tembakau yang kontroversial tetapi semakin dikenal. Untuk mencegah kebutaan seumur hidup, penelitian ini menekankan pentingnya diagnosis dini dan manajemen NAION yang menyeluruh pada pasien perokok berat. Dilaporkan seorang pria berusia 45 tahun mengeluhkan penglihatan mata kanan kabur sejak 1 minggu yang lalu. Penglihatan kabur dirasakan terutama hanya ketika melihat ke kanan dan ke bawah. Dia memiliki riwayat sakit kepala 1 minggu yang lalu. Dia juga merupakan seorang perokok aktif dengan kebiasaan merokok 1 bungkus/hari sejak 15 tahun yang lalu. Pemeriksaan visus jauh 0,5 pada kedua mata. Hasil tes konfrontasi menunjukkan penyempitan lapang pandang temporo-inferior OD. Pemeriksaan tonometri OD > 50 mmHg dan OS 17 mmHg. Pemeriksaan funduskopi langsung menemukan OD diskus optikus bulat dengan batas tidak jelas, berwarna kuning kemerahan, rasio C/D 0,3, rasio A/V 2/3.

References

American Academy of Ophthalmology. (2025). Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION). Eyewiki AAO [Internet]. https://eyewiki.org/Non-Arteritic_Anterior_Ischemic_Optic_Neuropathy_(NAION)#cite_note-preechawat7-27

Arianti, A., Rusmayani, E., & Viona, V. (2024). Insights into Ocular Emergencies: case Series on Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) Secondary to Acute Angle Closure Glaucoma. International medical case reports journal, 17, 507–519. https://doi.org/10.2147/IMCRJ.S458142

Arnold, A. C., Costa, R. M., & Dumitrascu, O. M. (2013). The spectrum of optic disc ischemia in patients younger than 50 years (an Amercian Ophthalmological Society thesis). Transactions of the American Ophthalmological Society, 111, 93–118. https://pmc.ncbi.nlm.nih.gov/articles/PMC3799463/

Behbehani, R., Ali, A., Al-Moosa, A. (2021). Risk factors and visual outcome of Non-Arteritic Ischemic Optic Neuropathy (NAION): Experience of a tertiary center in Kuwait. PLOS One, 16(2), e0247126. https://doi.org/10.1371/journal.pone.0247126

Chen, J.J. (2018). Are steroids effective in nonarteritic anterior ischemic optic neuropathy?. American Academy of Ophthalmology [Internet]. https://www.aao.org/education/editors-choice/are-steroids-effective-in-nonarteritic-anterior-is

Cheng, J. W., Cheng, S. W., Gao, L. D., Lu, G. C., & Wei, R. L. (2012). Intraocular pressure-lowering effects of commonly used fixed-combination drugs with timolol: a systematic review and meta-analysis. PloS one, 7(9), e45079. https://doi.org/10.1371/journal.pone.0045079

Chung, S. M., Gay, C. A., & McCrary, J. A., 3rd (1994). Nonarteritic ischemic optic neuropathy. The impact of tobacco use. Ophthalmology, 101(4), 779–782. https://doi.org/10.1016/s0161-6420(94)31266-8

Dwipayani, N.M., Triningrat, A.A.M.P., Manuaba, I.B.P. (2017). Karakteristik Penderita Nonarteritic Anterior Ischemic Optic Neuropathy di RSUP SAnglah Denpasar Tahun 2014-2015. Medicina, 48(3), 189-194. https://doi.org/10.15562/medicina.v48i3.155

Foster, R., Crum, O., Lesser, E., Hodge, D.O., Bhatti, M., Chen, J. (2019). Reexamining the incidence of nonarteritic anterior ischemic optic neuropathy. ARVO Journal Investigative Ophthalmology & Visual Science, 60, 2268. https://iovs.arvojournals.org/article.aspx?articleid=2742446

Guyer, D.R., Miller, N.R., Auer, C.L., Fine, S.L. (1985). The risk of cerebrovascular and cardiovascular disease in patients with anterior ischemic optic neuropathy. Arch Ophthalmol, 103, 1136 –1142.

Hayreh, S. S., & Zimmerman, M. B. (2008). Non-arteritic anterior ischemic optic neuropathy: role of systemic corticosteroid therapy. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 246(7), 1029–1046. https://doi.org/10.1007/s00417-008-0805-8

Hayreh, S. S., Jonas, J. B., & Zimmerman, M. B. (2007). Nonarteritic anterior ischemic optic neuropathy and tobacco smoking. Ophthalmology, 114(4), 804–809. https://doi.org/10.1016/j.ophtha.2006.07.062

Hayreh S. S. (1974). Anterior ischaemic optic neuropathy. III. Treatment, prophylaxis, and differential diagnosis. The British journal of ophthalmology, 58(12), 981–989. https://doi.org/10.1136/bjo.58.12.981

Hattenhauer, M. G., Leavitt, J. A., Hodge, D. O., Grill, R., & Gray, D. T. (1997). Incidence of nonarteritic anterior ischemic optic neuropathy. American journal of ophthalmology, 123(1), 103–107. https://doi.org/10.1016/s0002-9394(14)70999-7

Howard, L. (2023). New risk factor identified for potentially blinding condition. US Davis Health [Internet]. https://health.ucdavis.edu/news/headlines/new-risk-factor-identified-for-potentially-blinding-condition/2023/06

Kemchoknatee, P., Singhakul, C., Tangon, D., & Srisombut, T. (2022). Factors Associated With Visual Acuity in Non-arteritic Ischemic Optic Neuropathy Patients: A Five-Year Cross-Sectional Study. Cureus, 14(9), e29156. https://doi.org/10.7759/cureus.29156

Kim, D. H., Shin, G. R., & Choi, Y. J. (2017). Risk Factors for Non-arteritic Anterior Ischemic Optic Neuropathy in a Korean Population. Neuro-ophthalmology (Aeolus Press), 41(2), 68–75. https://doi.org/10.1080/01658107.2016.1267771

Lee, J. Y., Park, K. A., & Oh, S. Y. (2018). Prevalence and incidence of non-arteritic anterior ischemic optic neuropathy in South Korea: a nationwide population-based study. The British journal of ophthalmology, 102(7), 936–941. https://doi.org/10.1136/bjophthalmol-2017-311140

Lee, M. S., Grossman, D., Arnold, A. C., & Sloan, F. A. (2011). Incidence of nonarteritic anterior ischemic optic neuropathy: increased risk among diabetic patients. Ophthalmology, 118(5), 959–963. https://doi.org/10.1016/j.ophtha.2011.01.054

Liu, B., Yu, Y., Liu, W., Deng, T., & Xiang, D. (2021). Risk Factors for Non-arteritic Anterior Ischemic Optic Neuropathy: A Large Scale Meta-Analysis. Frontiers in medicine, 8, 618353. https://doi.org/10.3389/fmed.2021.618353

MedPath. (2017). Citicoline Effect on Non-arteritic Anterior Ischemic Optic Neuropathy (NAION).MedPath [Internet]. https://trial.medpath.com/clinical-trial/38304cc0ef7df705/citicoline-effect-non-arteritic-anterior-ischemic-optic-neuropathy

Parisi, V., Barbano, L., Di Renzo, A., Coppola, G., & Ziccardi, L. (2019). Neuroenhancement and neuroprotection by oral solution citicoline in non-arteritic ischemic optic neuropathy as a model of neurodegeneration: A randomized pilot study. PloS one, 14(7), e0220435. https://doi.org/10.1371/journal.pone.0220435

Preechawat, P., Bruce, B.B., Newman, N.J., Biousse, V. (2007). Anterior Ischemic Optic Neuropathy in Patients Younger than 50 Years. American Journal of Ophthalmology, 144, 953-960. https://www.ophed.net/system/files/2011/08/preechawat-2997-2997.pdf

Raizada K, Margolin E. (2025). Non-Arteritic Anterior Ischemic Optic Neuropathy. In: StatPearls [Internet]. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK559045/

Rebolleda, G., Pérez-López, M., Casas-LLera, P., Contreras, I., & Muñoz-Negrete, F. J. (2013). Visual and anatomical outcomes of non-arteritic anterior ischemic optic neuropathy with high-dose systemic corticosteroids. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 251(1), 255–260. https://doi.org/10.1007/s00417-012-1995-7

Van den Heever, H., & Meyer, D. (2016). The intraocular pressure-lowering properties of intravenous paracetamol. Clinical ophthalmology (Auckland, N.Z.), 10, 1283–1289. https://doi.org/10.2147/OPTH.S87988

Wanichwecharungruang, B., & Chantra, S. (2009). Non-arteritic anterior ischaemic optic neuropathy associated with neovascular glaucoma. BMJ case reports. https://doi.org/10.1136/bcr.07.2008.0483

Wu, K.Y., & Evoy, F. (2022). NAION: Diagnosis and Management. American Academy of Ophthalmology [Internet]. https://www.aao.org/eyenet/article/naion-diagnosis-and-management

Zulkarnaen, M., Nusanti, S., Sidik, M., Rachman, A. (2021). A Five-Year Data in Descriptive Study of Systemic and Ocular Risk Factors of Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) and The Correlation to The Clinical Condition. Ophthalmol Ina, 47(1), 93-101.

Downloads

Published

2025-08-20

How to Cite

Kirana, N. A. C., & Hayati, H. (2025). NON-ARTERITIC ANTERIOR ISCHEMIC OPTIC NEUROPATHY IN SMOKER ADULTS. PREPOTIF : JURNAL KESEHATAN MASYARAKAT, 9(2), 4807–4814. https://doi.org/10.31004/prepotif.v9i2.47968