LEAN AND SIX SIGMA IMPLEMENTATION IN HOSPITAL PHARMACY SETTING: A LITERATURE REVIEW
DOI:
https://doi.org/10.31004/prepotif.v9i2.46337Keywords:
Hospital Pharmacy, Implementation, Lean, Quality_Improvement, Six_sigmaAbstract
Lean dan Six Sigma merupakan pendekatan manajemen mutu yang telah banyak diadopsi di sektor pelayanan kesehatan, termasuk di instalasi farmasi rumah sakit, guna meningkatkan efisiensi dan kualitas pelayanan. Penelitian ini bertujuan untuk meninjau dan mengidentifikasi metodologi yang digunakan, intervensi yang diterapkan, serta dampak implementasi Lean dan Six Sigma terhadap berbagai indikator kinerja di lingkungan farmasi rumah sakit. Tinjauan sistematis dilakukan menggunakan tiga database utama, yaitu Scopus, PubMed, dan Science Direct, dengan kata kunci “Lean” ATAU “Six Sigma” DAN “Farmasi”, serta mengikuti pedoman PRISMA. Dari 54 artikel yang teridentifikasi, 11 artikel memenuhi kriteria inklusi. Hasil analisis menunjukkan lima metodologi implementasi, dengan metode DMAIC (Define, Measure, Analyze, Improve, Control) sebagai yang paling dominan. Sebanyak 40 intervensi ditemukan dalam studi terpilih dan diklasifikasikan ke dalam enam kategori utama, dengan tiga intervensi paling umum meliputi pengembangan proses atau sistem baru, penyediaan alat atau instrumen, dan perancangan ulang tata letak. Evaluasi dampak menggunakan lima kategori indikator utama menunjukkan bahwa penerapan Lean dan Six Sigma secara umum berdampak positif, seperti penurunan waktu layanan, pengurangan kesalahan pengobatan dan biaya, serta peningkatan kualitas, volume produksi, dan kepuasan pasien. Diperlukan penelitian lanjutan di berbagai konteks farmasi rumah sakit untuk mengeksplorasi indikator-indikator lain yang relevan.References
Abdel-Qader, D.H., Al Meslamani, A.Z., Lewis, P.J., and Hamadi, S., 2021. Incidence, nature, severity, and causes of dispensing errors in community pharmacies in Jordan, International Journal of Clinical Pharmacy, 43(1), pp. 165–173, https://doi.org/10.1007/S11096-020-01126-W/METRICS.
Al Kuwaiti, A., 2016, Application of six sigma methodology to reduce medication errors in the outpatient pharmacy unit: A case study from the King Fahd University Hospital, Saudi Arabia, International Journal for Quality Research, 10(2), pp. 267–278, https://doi.org/10.18421/IJQR10.02-03.
Al Nemari, M. and Waterson, J., 2022, The Introduction of Robotics to an Outpatient Dispensing and Medication Management Process in Saudi Arabia: Retrospective Review of a Pharmacy-led Multidisciplinary Six Sigma Performance Improvement Project, JMIR Human Factors, 9(4), pp. 1–16, https://doi.org/10.2196/37905.
Arafeh, M., Barghash, M.A., Sallam, E., and AlSamhouri, A., 2014, Six Sigma applied to reduce patients’ waiting time in a cancer pharmacy, International Journal of Six Sigma and Competitive Advantage, 8(2), pp. 105–124, https://doi.org/10.1504/IJSSCA.2014.064256.
Bender, J.S., Nicolescu, T.O., Hollingsworth, S.B., Murer, K., Wallace, K.R., and Ertl, W.J., 2015, Improving operating room efficiency via an interprofessional approach, American Journal of Surgery, 209(3), pp. 447–450, https://doi.org/10.1016/j.amjsurg.2014.12.007.
Bertolaccini, L., Viti, A. and Terzi, A., 2015, The Statistical point of view of Quality: the Lean Six Sigma methodology, Journal of Thoracic Disease, 7(4), p. E66, https://doi.org/10.3978/J.ISSN.2072-1439.2015.04.11.
Breen, L.M., Trepp, R. and Gavin, N., 2020, Lean Process Improvement in the Emergency Department, Emergency Medicine Clinics of North America, 38(3), pp. 633–646, https://doi.org/10.1016/j.emc.2020.05.001.
De Mast, J. and Lokkerbol, J., 2012, An analysis of the Six Sigma DMAIC method from the perspective of problem solving, International Journal of Production Economics, 139(2), pp. 604–614, https://doi.org/10.1016/j.ijpe.2012.05.035.
Found, P. and Harrison, R., 2012, Understanding the lean voice of the customer, International Journal of Lean Six Sigma, 3(3), pp. 251–267, https://doi.org/10.1108/20401461211282736.
Gabutti, I., Mascia, D. and Cicchetti, A., 2017, Exploring ‘patient-centered’ hospitals: a systematic review to understand change, BMC Health Services Research, 17(1), pp. 1–16, https://doi.org/10.1186/s12913-017-2306-0.
Gao, T., Zhang, X., Gurd, B., and Liu, Z., 2020, From self-management to a systemized process: the implementation of lean management in a Chinese hospital’s pharmacy intravenous admixture services center, Leadership in Health Services, 33(4), pp. 325–337, https://doi.org/10.1108/LHS-12-2019-0085.
Graban, M, 2016, Lean Hospitals, CRC Press Taylor & Francis Group, Florida USA.
Hammoudeh, S., Amireh, A., Jaddoua, S., Nazer, L., Jazairy, E., and Al-Dewiri, R., 2021, The Impact of Lean Management Implementation on Waiting Time and Satisfaction of Patients and Staff at an Outpatient Pharmacy of a Comprehensive Cancer Center in Jordan, Hospital Pharmacy, 56(6), pp. 737–744, https://doi.org/10.1177/0018578720954147.
Hlubocky, J., Brummond, P. and Clark, J.S., 2013, Pharmacy practice model change: lean thinking provides a place to start., American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 70(10), pp. 845–847, https://doi.org/10.2146/ajhp120528.
Ilangakoon, T.S., Weerabahu, S.K., Samaranayake, P., dan Wickramarachchi, R., 2022, Adoption of Industry 4.0 and lean concepts in hospitals for healthcare operational performance improvement, International Journal of Productivity and Performance Management, 71(6), pp. 2188–2213, https://doi.org/10.1108/IJPPM-12-2020-0654/FULL/XML.
Isfahani, H.M., Tourani, S. and Seyedin, H., 2019, Lean management approach in hospitals: a systematic review, International Journal of Lean Six Sigma, 10(1), pp. 161–188, https://doi.org/10.1108/IJLSS-05-2017-0051.
Iswanto, A.H. and Rosady, S.D., 2020, Monitoring and evaluation of Lean implementation in pediatric pharmacy: A study of mother and child hospital in Jakarta Correspondance, Systematic Reviews in Pharmacy, 11(6), pp. 939–945.
Kanamori, S., Sow, S., Castro, M.C., Matsuno, R., Tsuru, A., and Jimba, M., 2015, Implementation of 5S management method for lean healthcare at a health center in Senegal: A qualitative study of staff perception, Global Health Action, 8(1), pp. 1–9, https://doi.org/10.3402/gha.v8.27256.
Kementerian Kesehatan, 2016, Peraturan Menteri Kesehatan Republik Indonesia Nomor 72 Tahun 2016 Tentang Standar Pelayanan Kefarmasian di Rumah Sakit, Indonesia.
Kovacevic, M., Jovicic, M., Djapan, M., and Zivanovic-Macuzic, I., 2016, Lean thinking in healthcare: Review of implementation results, International Journal for Quality Research, 10(1), pp. 219–230, https://doi.org/10.18421/IJQR10.01-12.
Kwak, Y.H. and Anbari, F.T., 2006, Benefits, obstacles, and future of six sigma approach, Technovation, 26(5–6), pp. 708–715. https://doi.org/10.1016/j.technovation.2004.10.003.
Lawal, A.K., Rotter, T., Kinsman, L., Sari, N., Harrison, L., Jeffery, C. et al., 2014, Lean management in health care: Definition, concepts, methodology and effects reported (systematic review protocol), Systematic Reviews, 3(1), pp. 1–6, https://doi.org/10.1186/2046-4053-3-103.
Lim, J.S., Lim, K.S., Heinrichs, J.H., Al-Aali, K., Aamir, A., and Qureshi, M.I., 2018, The role of hospital service quality in developing the satisfaction of the patients and hospital performance, Management Science Letters, 8(12), pp. 1353–1362, https://doi.org/10.5267/J.MSL.2018.9.004.
Lv, L., Yao, Y., Zhang, M., and Xin, C., 2025, Impact of Implementing the Lean Management on Internal Errors at an Outpatient Hospital Pharmacy in China, Patient Preference and Adherence , 19(November 2024), pp. 139–147, https://doi.org/10.2147/PPA.S486478.
Matos, Ai.A., Alves, A.C. and Tereso, A.P., 2016, Lean Principles in an Operating Room Environment, Journal of Health Management, 18(2), pp. 239–257, https://doi.org/10.1177/0972063416637716.
Mbuzi, V., Fulbrook, P. and Jessup, M., 2018, Effectiveness of programs to promote cardiovascular health of Indigenous Australians: A systematic review, International Journal for Equity in Health, 17(1), pp. 1–17, https://doi.org/10.1186/s12939-018-0867-0.
Niñerola, A., Sánchez-Rebull, M.V. and Hernández-Lara, A.B., 2020, Quality improvement in healthcare: Six Sigma systematic review,” Health Policy, 124(4), pp. 438–445, https://doi.org/10.1016/j.healthpol.2020.01.002.
Ortíz-Barrios, M.A., Escorcia-Caballero, J.P., Sánchez-Sánchez, F., De Felice, F., and Petrillo, A., 2017, Efficiency Analysis of Integrated Public Hospital Networks in Outpatient Internal Medicine, Journal of Medical Systems, 41(10), pp. 1–18, https://doi.org/10.1007/S10916-017-0812-6/METRICS.
Page, M.J., McKenzie, J.E., Bossuyt, P.M., Boutron, I., Hoffmann, T.C., Mulrow, C.D. et al., 2021, The PRISMA 2020 statement: An updated guideline for reporting systematic reviews, The BMJ. BMJ, https://doi.org/10.1136/bmj.n71.
Poole, S.G., Kwong, E., Mok, B., Mulqueeny, B., Yi, M., Percival, M.A. et al., 2021, Interventions to decrease the incidence of dispensing errors in hospital pharmacy: a systematic review and meta-analysis, Journal of Pharmacy Practice and Research, 51(1), pp. 7–21, https://doi.org/10.1002/jppr.1709.
Putri, L.R., 2017, Pendekatan Lean Hospital untuk Mengidentifikasi Waste Kritis di Instalasi Farmasi Rawat Jalan RSI PKU Muhammadiyah Pekajangan (MSc thesis), Universitas Muhammadiyah Yogyakarta, http://repository.umy.ac.id/handle/123456789/11517.
Rahayu, D.S., Sunarni, T. and Saptarini, O., 2021, Pendekatan Lean Hospital Untuk Mengidentifikasi Waste Kritis Pelayanan Obat Di Instalasi Farmasi Rawat Jalan Rsud X Manna Tahun 2020, Media Ilmu Kesehatan, 9(3), pp. 231–236, https://doi.org/10.30989/mik.v9i3.509.
Reilly, R., Evans, K., Gomersall, J., Gorham, G., Peters, M.D.J., Warren, S. et al., 2016, Effectiveness, cost effectiveness, acceptability and implementation barriers/enablers of chronic kidney disease management programs for Indigenous people in Australia, New Zealand and Canada: A systematic review of mixed evidence, BMC Health Services Research, 16(1), https://doi.org/10.1186/s12913-016-1363-0.
Rico, R.A. and Jagwani, J.M., 2013, Application of lean methods to compounding services in hospital pharmacy, European Journal of Hospital Pharmacy, 20(3), pp. 168–173, https://doi.org/10.1136/ejhpharm-2012-000221.
Sallam, M., Allam, D. and Kassem, R., 2024, Improving Efficiency in Hospital Pharmacy Services: An Integrated Strategy Using the OCTAGON-P Framework and Lean 5S Management Practices, Cureus, 16(3), https://doi.org/10.7759/cureus.56965.
Shortell, S.M., Blodgett, J.C., Rundall, T.G., Henke, R.M., and Reponen, E., 2021, Lean Management and Hospital Performance: Adoption vs. Implementation, The Joint Commission Journal on Quality and Patient Safety, 47(5), pp. 296–305, https://doi.org/10.1016/J.JCJQ.2021.01.010.
Soubra, L. and Karout, S., 2021, Dispensing errors in Lebanese community pharmacies: incidence, types, underlying causes, and associated factors, Pharmacy Practice, 19(1), pp. 1–7, https://doi.org/10.18549/PHARMPRACT.2021.1.2170.
Sullivan, P., Soefje, S., Reinhart, D., McGeary, C., and Cabie, E.D., 2014, Using lean methodology to improve productivity in a hospital oncology pharmacy, American Journal of Health-System Pharmacy, 71(17), pp. 1491–1498, https://doi.org/10.2146/ajhp130436.
Talero-Sarmiento, L.H., Escobar-Rodríguez, L.Y., Gomez-Avila, F.L., and Parra-Sanchez, D.T., 2024, A literature review on Lean healthcare: implementation strategies, challenges, and future research directions, Cogent Engineering, 11(1), p, https://doi.org/10.1080/23311916.2024.2411857.
Trakulsunti, Y., Antony, J., Edgeman, R., Cudney, B., Dempsey, M., and Brennan, A., 2022, Reducing pharmacy medication errors using Lean Six Sigma: A Thai hospital case study, Total Quality Management and Business Excellence, 33(5–6), pp. 664–682, https://doi.org/10.1080/14783363.2021.1885292.
Tu, H.N., Shan, T.H., Wu, Y.C., Shen, P.H., Wu, T.Y., Lin, W.L. et al., 2023. Reducing Medication Errors by Adopting Automatic Dispensing Cabinets in Critical Care Units, Journal of Medical Systems, 47(1), pp. 1–7, https://doi.org/10.1007/S10916-023-01953-0/TABLES/4.
Tufanaru, C., Munn, Z., Aromataris, E., Campbell, J., and Hopp, L., 2020, Checklist for Quasi-Experimental Studies (Non-randomized Experimental Studies), JBI Manual for Evidence Synthesis [Preprint], https://synthesismanual.jbi.global.
Vaishnavi, V. and Suresh, M., 2020, Modelling of readiness factors for the implementation of Lean Six Sigma in healthcare organizations, International Journal of Lean Six Sigma, 11(4), pp. 597–633, https://doi.org/10.1108/IJLSS-12-2017-0146.
Xesfingi, S. and Vozikis, A., 2016, Patient satisfaction with the healthcare system: Assessing the impact of socio-economic and healthcare provision factors, BMC Health Services Research, 16(1), pp. 1–7, https://doi.org/10.1186/S12913-016-1327-4/TABLES/2.
Yuliati, V. and Andriani, H., 2021, Implementation of lean kaizen to reduce waiting time for the Indonesian health social security agency prescription services in hospital pharmacy installation, Open Access Macedonian Journal of Medical Sciences, 9, pp. 1495–1503, https://doi.org/10.3889/oamjms.2021.7610.
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