EVALUASI HASIL FUNGSIONAL PADA OSTEOARTRITIS LUTUT DERAJAT III SETELAH INJEKSI ASAM HIALURONAT DENGAN DAN TANPA REHABILITASI BERDASARKAN SKOR KOOS DI RSAU DR. DODY SARDJOTO
DOI:
https://doi.org/10.31004/prepotif.v9i1.43957Keywords:
fisioterapi, injeksi intraartikular, kombinasi terapi, osteoartritis lutut, skor KOOSAbstract
Osteoartritis lutut merupakan penyakit degeneratif yang menyebabkan nyeri dan gangguan fungsi sendi. Injeksi asam hialuronat intraartikular digunakan untuk meningkatkan viskositas cairan sinovial dan mengurangi nyeri, sedangkan fisioterapi membantu memperbaiki biomekanik sendi. Kombinasi kedua terapi ini berpotensi meningkatkan fungsi lutut lebih baik dibandingkan terapi tunggal. Penelitian ini merupakan quasi-experimental study dengan pendekatan non-randomized controlled trial yang membandingkan tiga kelompok perlakuan: injeksi intraartikular asam hialuronat, injeksi intraartikular dengan fisioterapi, dan tanpa intervensi. Evaluasi klinis menggunakan Skor KOOS, yang mencakup nyeri, gejala, aktivitas sehari-hari, aktivitas olahraga, dan kualitas hidup. Analisis statistik menggunakan uji ANOVA dan uji post hoc Tukey HSD. Skor Tanda dan Gejala serta Total Fungsional menunjukkan perbedaan bermakna (p=0.009 dan p=0.025). Kelompok suntik dengan fisioterapi memiliki perbaikan fungsional terbaik (72.10 ± 13.80), sedangkan kelompok suntik tanpa fisioterapi menunjukkan gejala lebih berat (110.20 ± 30.50). Kombinasi injeksi intraartikular dan fisioterapi lebih efektif dalam meningkatkan fungsi lutut dan menurunkan gejala dibandingkan terapi tunggal. Penelitian ini mendukung rehabilitasi sebagai bagian dari pengelolaan osteoartritis lutut derajat III.References
Asadpour, N., Shooshtari, Z., Kazemian, M., Gholami, M., Vatanparast, N., & Samieirad, S. (2022). Combined platelet-rich plasma and hyaluronic acid can reduce pain in patients undergoing arthrocentesis for temporomandibular joint osteoarthritis. Journal of Oral and Maxillofacial Surgery, 80(9), 1474-1485.
Bansal, A., Goyal, A., Gamanagatti, S., Srivastava, D. N., & Manhas, V. (2021). Current updates in image-guided musculoskeletal interventions. Journal of Clinical Orthopaedics and Trauma, 22, 101601.
Derwich, M., Mitus-Kenig, M., & Pawlowska, E. (2021). Mechanisms of action and efficacy of hyaluronic acid, corticosteroids and platelet-rich plasma in the treatment of temporomandibular joint osteoarthritis—a systematic review. International journal of molecular sciences, 22(14), 7405.
Fiz, N., Delgado, D., Garate, A., Sánchez, P., Oraa, J., Bilbao, A. M., ... & Sánchez, M. (2020). Intraosseous infiltrations of Platelet-Rich Plasma for severe hip osteoarthritis: A pilot study. Journal of clinical orthopaedics and trauma, 11, S585-S590.
Froschauer, S. M., Holzbauer, M., Wenny, R., Schmidt, M., Huemer, G. M., Kwasny, O., & Duscher, D. (2020). Autologous fat transplantation for thumb carpometacarpal joint osteoarthritis (Liparthroplasty): A case series with two years of follow-up. Journal of Clinical Medicine, 10(1), 113.
Galla, R., Ruga, S., Aprile, S., Ferrari, S., Brovero, A., Grosa, G., ... & Uberti, F. (2022). New Hyaluronic Acid from Plant Origin to Improve Joint Protection—An In Vitro Study. International Journal of Molecular Sciences, 23(15), 8114.
Hamawandi S. Use of Hyaluronic Acid Injection After Arthroscopic Release in Lateral Patellar Compression Syndrome With Degenerative Cartilage Changes: Randomized Control Trial. BMC Musculoskelet Disord. 2021;
Hegaze, A. H., Hamdi, A. S., Alqrache, A., Hegazy, M., & Hamdi, A. (2021). Efficacy of platelet-rich plasma on pain and function in the treatment of knee osteoarthritis: A prospective cohort study. Cureus, 13(3).
Heidari, N., Slevin, M., Zeinolabediny, Y., Meloni, D., Olgiati, S., Wilson, A., ... & Azamfirei, L. (2022). Comparison of the effect of MFAT and MFAT+ PRP on treatment of hip osteoarthritis: an observational, intention-to-treat study at one year. Journal of Clinical Medicine, 11(4), 1056.
Pérez-Lozano, M. L., Cesaro, A., Mazor, M., Esteve, E., Berteina-Raboin, S., Best, T. M., ... & Toumi, H. (2021). Emerging natural-product-based treatments for the management of osteoarthritis. Antioxidants, 10(2), 265.
Sultan OI. Clinical Evaluation Comparing the Effect of Intra-Articular Injections of Platelet Rich Plasma Versus Injectable Platelet Rich Fibrin in Conjunction With Arthrocentesis in Management of Temporomandibular Joint Osteoarthritis. Msa Dent J. 2024;
Vasso, M., Corona, K., Capasso, L., Toro, G., & Schiavone Panni, A. (2022). Intraarticular injection of microfragmented adipose tissue plus arthroscopy in isolated primary patellofemoral osteoarthritis is clinically effective and not affected by age, BMI, or stage of osteoarthritis. Journal of Orthopaedics and Traumatology, 23(1), 7.
Vitale, N. D., Vandenbulcke, F., Chisari, E., Iacono, F., Lovato, L., Di Matteo, B., & Kon, E. (2019). Innovative regenerative medicine in the management of knee OA: the role of autologous protein solution. Journal of clinical orthopaedics and trauma, 10(1), 49-52.
Wang, K., Xing, D., Dong, S., & Lin, J. (2019). The global state of research in nonsurgical treatment of knee osteoarthritis: a bibliometric and visualized study. BMC musculoskeletal disorders, 20, 1-10.
Xia, P., Wang, Q., Song, J., Wang, X., Wang, X., Lin, Q., ... & Li, X. (2022). Low-Intensity Pulsed Ultrasound Enhances the Efficacy of Bone Marrow–Derived MSCs in Osteoarthritis Cartilage Repair by Regulating Autophagy-Mediated Exosome Release. Cartilage, 13(2), 19476035221093060.
Yi, Y. H., Chen, G., Gong, S., Han, L. Z., Gong, T. L., Wang, Y. X., ... & Jin, X. (2023). Injectable temperature-sensitive hydrogel loaded with IL-36Ra for the relief of osteoarthritis. ACS biomaterials science & engineering, 9(3), 1672-1681.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Zainarda Zainarda, Diana Novita Sari, Muhammad Faizal Hidayah Putra, Siti Rahma Supu, Nabila Rizmi Pradina

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work’s authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal’s published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).







