THE APPEAL OF VITAMIN D SUPPLEMENTATION IN ATOPIC DERMATITIS TREATMENT FOR CHILDREN : A LITERATURE REVIEW
DOI:
https://doi.org/10.31004/prepotif.v9i1.38506Keywords:
Vitamin D, Supplementation, Atopic dermatitis, ChildrenAbstract
Dermatitis atopik (DA) adalah penyakit kulit yang umum terjadi pada anak-anak, yang menyebabkan kulit meradang, gatal, bersisik, dan kering. DA mempengaruhi 15-20% populasi anak di dunia. DA dapat menurunkan kualitas hidup, terutama pada kasus yang parah. Kulit gatal menyebabkan gangguan tidur, baik pada anak maupun orang tua, rasa malu, biaya pengobatan dan rendahnya produktivitas secara keseluruhan. Oleh karena itu, tinjauan literatur ini bertujuan untuk menyelidiki secara komprehensif daya tarik suplementasi vitamin D sebagai pilihan pengobatan tambahan terhadap DA. Tujuan dari tinjauan ini adalah untuk mengetahui peran vitamin D dalam pengobatan DA dengan mengumpulkan dan menganalisis temuan terkini dalam literatur ilmiah. Penelitian mengambil sumber database akademis dari Pubmed, Science Direct, dan Chocrane dengan menggunakan kata kunci yang relevan seperti “vitamin D”, “kalsiferol”, “dermatitis atopik”, dan “anak-anak” yang setelah dilakukan screening diambil 11 artikel untuk dianalisis lebih lanjut. . Pasien DA umumnya memiliki kadar serum vitamin D yang lebih rendah dan pasien dengan kadar serum 25(OH)D yang lebih rendah lebih mungkin menderita DA sedang dan berat. Vitamin D oral (1000-1600 IU/hari) secara signifikan meningkatkan gejala klinis dan mengurangi keparahan penyakit berdasarkan indeks SCORAD. Pemahaman mendalam tentang manfaat suplementasi vitamin D dalam pengobatan DA pada anak-anak adalah penting untuk pengembangan strategi terapi DA, terutama dengan mempertimbangkan dosis, usia, wilayah geografis, karena pengobatan DA yang memadai pada anak-anak dapat mencegah perkembangan lebih lanjut. dari pawai atopik.References
Aldaghi, M., Tehrani, H., Karrabi, M., Abadi, F. S., & Sahebkar, M. (2022). The effect of multistrain synbiotic and vitamin D3 supplements on the severity of atopic dermatitis among infants under 1 year of age: a double-blind, randomized clinical trial study. Journal of Dermatological Treatment, 33(2), 812–817. doi: 10.1080/09546634.2020.1782319
Borzutzky, A., Grob, F., Camargo, C.A. Jr, Martinez-Aguayo, A. (2014). Vitamin D deficiency rickets in an adolescent with severe atopic dermatitis. Pediatrics. 133(2):e451-4. doi: 10.1542/peds.2013-1114
Bylund, S., Kobyletzki, L.B., Svalstedt, M., Svensson, Å. (2020). Prevalence and Incidence of Atopic Dermatitis: A Systematic Review. Acta Derm Venereol, 100(12):adv00160. doi: 10.2340/00015555-3510
Camargo, C.A. Jr, Ganmaa, D., Sidbury, R., Erdenedelger, K.H., Radnaakhand, N., Khandsuren, B. (2014). Randomized trial of vitamin D supplementation for winter-related atopic dermatitis in children. J Allergy Clin Immunol. 134(4):831-835.e1. doi: 10.1016/j.jaci.2014.08.002
Di Filippo, P., Scaparrotta, A., Rapino, D., Cingolani, A., Attanasi, M., Petrosino, M. I., Chuang, K., Di Pillo, S., Chiarelli, F. (2015). Vitamin D Supplementation Modulates the Immune System and Improves Atopic Dermatitis in Children. International Archives of Allergy and Immunology, 166, 91-96. doi: 10.1159/000371350
Dogru, M. (2018). Is vitamin D level associated with the natural course of atopic dermatitis? Allergologia et immunopathologia, 46(6), 546-551. doi: 10.1016/j.aller.2017.12.004
Fuxench, Z.C.C., Mitra, N., Del Pozo, D., Hoffstad, O., Shin, D.B., Margolis, D.J. (2023). Risk of atopic dermatitis and the atopic march paradigm in children of mothers with atopic illnesses: A birth cohort study from the United Kingdom, Journal of the American Academy of Dermatology, 90 (3), 561-568, doi: 10.1016/j.jaad.2023.11.013
Hattangdi-Haridas, S.R., Lanham-New, S.A., Wong, W.H.S., Ho, M.H.K., Darling, A.L. (2019). Vitamin D Deficiency and Effects of Vitamin D Supplementation on Disease Severity in Patients with Atopic Dermatitis: A Systematic Review and Meta-Analysis in Adults and Children. Nutrients, 11(8), 1854. doi: 10.3390/nu11081854
Hidayati, A.N., Sawitri, S., Sari, D.W., Prakoeswa, C.R.S., Indramaya, D.M., Damayanti, D., Zulkarnain, I., Citrashanty, I., Widia, Y., Anggraeni, S. (2023). Efficacy of vitamin D supplementation on the severity of atopic dermatitis in children: A systematic review and meta-analysis [version 2; peer review: 2 approved]. F1000Research, 11(274). doi: 10.12688/f1000research.106957.2
Huang CM, Lara-Corrales I, Pope E. (2018). Effects of Vitamin D levels and supplementation on atopic dermatitis: A systematic review. Pediatr Dermatol. 35(6):754-760. doi: 10.1111/pde.13639. Epub 2018 Oct 3. PMID: 30284328.
Kim, G., Bae, J.H. (2016). Vitamin D and atopic dermatitis: A systematic review and meta-analysis. Nutrition, 32(9), 913-20. doi: 10.1016/j.nut.2016.01.023
Kim, M.J., Kim, S.N., Lee, Y.W., Choe, Y.B., Ahn, K.J. (2016). Vitamin D Status and Efficacy of Vitamin D Supplementation in Atopic Dermatitis: A Systematic Review and Meta-Analysis. Nutrients. 8(12), 789. doi: 10.3390/nu8120789
Lee, Y.W., Choon, S.E., Izham, S. (2019). Serum 25-Hydroxyvitamin D deficiency in Malaysian children with severe atopic dermatitis. Med J Malaysia. 74(4), 259-265. PMID: 31424030.
Li, Q., Zhou, Q., Zhang, G., Tian, X., Li, Y., Wang, Z., Zhao, Y., Chen, Y., Luo, Z. (2022). Vitamin D Supplementation and Allergic Diseases during Childhood: A Systematic Review and Meta-Analysis. Nutrients, 14(19), 3947. doi: 10.3390/nu14193947
Lim, J.J., Liu, M.H., Chew, F.T. (2024). Dietary Interventions in Atopic Dermatitis: A Comprehensive Scoping Review and Analysis. Int Arch Allergy Immunol, 185(6), 545-589. doi: 10.1159/000535903
Limanda, C., Gabriella, G., Bernadetta, E., Hakim, J., Tansuri, V. (2024). Role of Vitamin D in the Treatment of Atopic Dermatitis. Indonesian Journal of Global Health Research, 6(4), 1861-1872. doi: 10.37287/ijghr.v6i4.3195
Lyons, J.J., Milner, J.D., Stone, K.D. (2015). Atopic dermatitis in children: clinical features, pathophysiology, and treatment. Immunol Allergy Clin North Am, 35(1), 161-83. doi: 10.1016/j.iac.2014.09.008
Mansour, N.O., Mohamed, A.A., Hussein, M., Eldemiry, E., Daifalla, A., Hassanin, S., Nassar, N., Ghaith, D., Mohamed, S.E. (2020). The impact of vitamin D supplementation as an adjuvant therapy on clinical outcomes in patients with severe atopic dermatitis: A randomized controlled trial. Pharmacol Res Perspect, 8(6), e00679. doi: 10.1002/prp2.679
Nursalam. (2016). Metodologi Penelitian Ilmu Keperawatan. Jakarta: Selemba Medika.
Özdemir, O. (2024). Vitamin D, allergen sensitization, and atopic dermatitis. World Allergy Organization Journal, 17(11), 100978. doi: 10.1016/j.waojou.2024.100978
Paré, G., Kitsiou, S. (2017). Chapter 9 Methods for Literature Reviews. In: Lau F, Kuziemsky C, editors. Handbook of eHealth Evaluation: An Evidence-based Approach. Victoria (BC): University of Victoria. Available from: https://www.ncbi.nlm.nih.gov/books/NBK481583/
Park, J.S., Kim, M., Sol, I.S., Lee, K.S., Park, S., Yang, H.J., Lee, E. (2023). Effect of Vitamin D on the Treatment of Atopic Dermatitis With Consideration of Heterogeneities: Meta-Analysis of Randomized Controlled Trials. Allergy Asthma Immunol Res. 15(2):262-270. https://doi.org/10.4168/aair.2023.15.2.262
Raj, K. A. P., Handa, S., Narang, T., Sachdeva, N., Mahajan, R. (2022). Correlation of serum vitamin D levels with severity of pediatric atopic dermatitis and the impact of vitamin D supplementation on treatment outcomes. Journal of Dermatological Treatment, 33(3), 1397–1400. doi: 10.1080/09546634.2020.1818677
Ren, Y., Liu, J., Li, W., Zheng, H., Dai, H., Qiu, G., Yu, D., Yao, D., Yin, X. (2022). Causal Associations between Vitamin D Levels and Psoriasis, Atopic Dermatitis, and Vitiligo: A Bidirectional Two-Sample Mendelian Randomization Analysis. Nutrients, 14(24), 5284. doi: 10.3390/nu14245284
Sanmartin, R., Pardos, C., Doste, D., Aguilera, J., Alijarde, R., Jesús Agón-Banzo, P., García-Malinis, A.J., Puzo, J., Hernández-Martín, Á., Gilaberte, Y. (2020). The association between atopic dermatitis and serum 25-hydroxyvitamin D in children: Influence of sun exposure, diet, and atopy features: A cross-sectional study. Pediatr Dermatol. 37(2), 294-300. doi: 10.1111/pde.14049
Snyder, H. (2019). Literature review as a research methodology: An overview and guidelines. Journal of Business Research, 104(2019), 333-339. doi: 10.1016/j.jbusres.2019.07.039
Vestita, M., Filoni, A., Congedo, M., Foti, C., Bonamonte, D. (2015). Vitamin D and atopic dermatitis in childhood. J Immunol Res, 257879. doi: 10.1155/2015/257879.
Wollenberg, A., Werfel, T., Ring, J., Ott, H., Gieler, U., Weidinger, S. (2023). Atopic Dermatitis in Children and Adults—Diagnosis and Treatment. Dtsch Arztebl Int, 120(13), 224-234. doi: 10.3238/arztebl.m2023.0011
Xiang, J., Wang, H., Li, T. (2019). Comorbidity of Vitamin A and Vitamin D Deficiency Exacerbates the Severity of Atopic Dermatitis in Children. Dermatology, 235(3), 196-204. doi: 10.1159/000496603
Zhang, P., Xu, Q., Zhu, R. (2024). Vitamin D and allergic diseases. Front. Immunol., 15(2024). doi: 10.3389/fimmu.2024.1420883
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