PENAPISAN ANTIBODI TOXOPLASMA GONDII DAN PROFIL LEUKOSIT PADA DARAH DONOR

Authors

  • Meyta Wulandari Faculty of Mathematics and Natural Sciences, Universitas Palangka Raya, Indonesia
  • Ikrimah Nafilata Blood Bank Technology Study Programs, STIKes Guna Bangsa Yogyakarta, Indonesia
  • Sri Wijayanti Wulandari Faculty of Life Sciences, University of Bristol, United Kingdom

DOI:

https://doi.org/10.31004/prepotif.v8i2.31624

Keywords:

Darah, Donor, Leukosit, Penapisan, Transfusi Darah, Toksoplasma

Abstract

Keamanan produk darah merupakan prioritas bagi UTD dalam menyediakan komponen darah donor sebagai obat esensial yang memiliki risiko menularkan penyakit. Penapisan darah donor telah diatur dalam Peraturan Menteri Kesehatan No 91 tahun 2015 untuk uji empat parameter penyakit, diantaranya sifilis, HIV, hepatitis B dan hepatitis C. Toksoplasmosis merupakan infeksi protozoa yang dapat bersifat asimptomatik pada penderitanya. Prevalensi toksoplasma di Asia, khususnya di Indonesia cukup tinggi, sehingga perlu menjadi perhatian bagi UTD melakukan pengamanan darah donor. Infeksi toksoplasma dapat menyebabkan penyakit komorbit pada individu imunodefisiensi. Penularan toksoplasmosis terhadap penderita HIV dengan CD4 yang rendah dapat menyebabkan tambahan penyakit opurtunistik yaitu toksoplasma ensefalitis serta infeksi laten yang menunjukkan risiko komplikasi. Tujuan penelitian ini adalah mendeteksi antibodi IgG/IgM Toxoplasma gondii pada darah donor dengan desain penelitian deskriptif laboratorik. Sampel didapatkan dari 69 darah donor berupa serum. Deteksi antibodi yang dilakukan menggunakan Rapid Test Voyage Toxo IgG/IgM. Hasil menunjukkan bahwa terdapat 19% sampel reaktif toksoplasma antibodi imunoglobulin G (IgG), 81% sampel non reaktif IgG, tidak ditemukan sampel darah donor yang reaktif IgM (0%) dan profil leukosit pada sampel darah donor reaktif IgG diketahui leukosit jenis limfosit dan monosit, keduanya meningkat 85% dari nilai normal. Disimpulkan pendonor memiliki riwayat terinfeksi Toxoplasma gondii dan berpeluang dalam menularkan parasit melalui transfusi darah secara horizontal.

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Published

2024-08-23

How to Cite

Wulandari, M. ., Nafilata, I. ., & Wulandari, S. W. . (2024). PENAPISAN ANTIBODI TOXOPLASMA GONDII DAN PROFIL LEUKOSIT PADA DARAH DONOR. PREPOTIF : JURNAL KESEHATAN MASYARAKAT, 8(2), 4052–4059. https://doi.org/10.31004/prepotif.v8i2.31624

Issue

Vol. 8 No. 2 (2024): AGUSTUS 2024

Section

Articles

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Copyright (c) 2024 Meyta Wulandari, Ikrimah Nafilata, Sri Wijayanti Wulandari

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