PERBANDINGAN EFEKTIVITAS ANALGESIA PASCAOPERASI BLOK SUBKOSTAL TRANSVERSUS ABDOMINIS (STA) DENGAN OPIOID INTRAVENA PADA PASIEN OPERASI LAPAROSKOPI KOLESISTEKTOMI DI RSUP PROF. DR. I.G.N.G. NGOERAH DENPASAR

Authors

  • Dinar Kusuma Wardani Department of Anesthesiology, Pain Management, and Intensive Care, Udayana University, Sanglah General Hospital Bali
  • I.G.P.Sukrana Sidemen Department of Anesthesiology, Pain Management, and Intensive Care, Udayana University, Sanglah General Hospital Bali
  • I.G.A.G. Utara Hartawan Department of Anesthesiology, Pain Management, and Intensive Care, Udayana University, Sanglah General Hospital Bali
  • I Made Gede Widnyana Department of Anesthesiology, Pain Management, and Intensive Care, Udayana University, Sanglah General Hospital Bali
  • Pontisomaya Parami Department of Anesthesiology, Pain Management, and Intensive Care, Udayana University, Sanglah General Hospital Bali
  • Tjahya Aryasa EM Department of Anesthesiology, Pain Management, and Intensive Care, Udayana University, Sanglah General Hospital Bali
  • Made Wiryana Department of Anesthesiology, Pain Management, and Intensive Care, Udayana University, Sanglah General Hospital Bali
  • Tjokorda Gde Agung Senapathi Department of Anesthesiology, Pain Management, and Intensive Care, Udayana University, Sanglah General Hospital Bali

DOI:

https://doi.org/10.31004/prepotif.v8i1.27260

Keywords:

Analgetik, Blok Subkostal Transversus Abdomini, Kolesistektomi, Laparoskopi, Opioid

Abstract

Penelitian ini bertujuan untuk membedakan efektivitas antara blok STA dengan opioid intravena sebagai analgesia pascaoperasi laparoskopi kolesistektomi di RSUP Prof. Dr. I.G.N.G. Ngoerah Denpasar. Penelitian ini merupakan sebuah uji coba prospektif, acak, terkendali dan single-centered. Sebanyak 60 subjek pasien yang menjalani tindakan operasi laparoskopi dibagi menjadi 2 kelompok denganpemberian tindakan STA dan tanpa STA. Analisis data dillakukan dengan bantuan SPSS versi 36 meliputi uji Chi Square, independent t tets dan Mann Whitney. Hasil penelitian bahwa Blok STA pascaoperasi laparoskopi kolesistektomi memiliki intensitas nyeri dengan NRS pada jam ke 6, 12 dan 24 lebih rendah dibandingkan dengan yang hanya mendapatkan opioid intravena dengan nilai p<0,001. Blok STA memiliki total waktu pemberian analgesik rescue pertama 6,67±2,39 jam dan tanpa STA 1,87±0,81 jam dengan perbedaan 4,80 jam (IK95% 3,87-5,72; p<0,001). Blok STA memiliki jumlah muntah dalam 24 jam dengan rerata 0,50±0,97 kali dan tanpa STA 3,27±1,79 kali dengan perbedaan 2,76 kali (IK95% 2,01-3,51; p<0,001). Blok STA memiliki hasil NLR dengan rerata 2,52±1,71 dan tanpa STA 4,64±2,90 dengan perbedaan 2,12 (IK95% 0,89-3,35; p=0,001). Nilai NLR antara sebelum dan sesudah kelompok STA menurun sebesar 1,27±2,64 sedangkan kelompok tanpa STA meningkat rerata 1,33±1,87 dengan perbedaan 2,61 (IK 1,43-3,80; P<0,001). Tindakan blok STA dapat menurunkan efek nyeri, mual-muntah dan durasi analgetik lebih panjang dengan nilai NLR lebih rendah pascaoperasi laparoskopi kolesistektomi dibandingkan dengan tanpa STA.

References

Ahmed, A. M. (2020). Ultrasound Guided Subcostal Transversus Abdominis Plane Block For Postoperative Analgesia After Laparoscopic Cholecystectomy ( comparative Study Between Bubivacaine Versus Bubivacaine-Ketamine). Al-Azhar International Medical Journal, 1(9), 242–247. https://doi.org/10.21608/aimj.2020.27457.1190

Alsharari, A. F., Abuadas, F. H., Alnassrallah, Y. S., & Salihu, D. (2022). Transversus Abdominis Plane Block as a Strategy for Effective Pain Management in Patients with Pain during Laparoscopic Cholecystectomy: A Systematic Review. Journal of Clinical Medicine, 11(23), Article 23. https://doi.org/10.3390/jcm11236896

Altinpulluk, E. Y., Ozdilek, A., Colakoglu, N., Beyoglu, C. A., Ertas, A., Uzel, M., Yildirim, F. G., & Altindas, F. (2019). Bilateral postoperative ultrasound-guided erector spinae plane block in open abdominal hysterectomy: A case series and cadaveric investigation. Romanian Journal of Anaesthesia and Intensive Care, 26(1), 83–88.

Astuti, A. (2023). Pengaruh Kombinasi Healing Touch Dan Relaksasi Terhadap Penurunan Skala Nyeri Pasien Post Operasi Laparoscopy Cholelithiasis Di Primaya Hospital Makassar [Masters, Universitas Hasanuddin]. https://repository.unhas.ac.id/id/eprint/24969/

Bacal, V., Rana, U., McIsaac, D. I., & Chen, I. (2019). Transversus Abdominis Plane Block for Post Hysterectomy Pain: A Systematic Review and Meta-Analysis. Journal of Minimally Invasive Gynecology, 26(1), 40–52. https://doi.org/10.1016/j.jmig.2018.04.020

Balciscueta, I., Barberà, F., Lorenzo, J., Martínez, S., Sebastián, M., & Balciscueta, Z. (2021). Ambulatory laparoscopic cholecystectomy: Systematic review and meta-analysis of predictors of failure. Surgery, 170(2), 373–382. https://doi.org/10.1016/j.surg.2020.12.029

Baytar, Ç., Y?lmaz, C., Karasu, D., & Topal, S. (2019). Comparison of Ultrasound-Guided Subcostal Transversus Abdominis Plane Block and Quadratus Lumborum Block in Laparoscopic Cholecystectomy: A Prospective, Randomized, Controlled Clinical Study. Pain Research and Management, 2019, e2815301. https://doi.org/10.1155/2019/2815301

Cao, X., White, P. F., & Ma, H. (2017). An update on the management of postoperative nausea and vomiting. Journal of Anesthesia, 31(4), 617–626. https://doi.org/10.1007/s00540-017-2363-x

Chen, L., Yang, H., Li, H., He, C., Yang, L., & Lv, G. (2022). Insights into modifiable risk factors of cholelithiasis: A Mendelian randomization study. Hepatology, 75(4), 785–796. https://doi.org/10.1002/hep.32183

Coe, C., Shuttleworth, P. W., Rangappa, D., & Abdel-Halim, M. (2023). Locoregional Anaesthesia for Laparotomy: A Literature Review and Subsequent Case Series Highlighting the Potential of an Alternative Anaesthetic Technique. Cureus, 15(9). https://www.cureus.com/articles/158586-locoregional-anaesthesia-for-laparotomy-a-literature-review-and-subsequent-case-series-highlighting-the-potential-of-an-alternative-anaesthetic-technique.pdf

Espadas-González, L., Usón-Casaús, J. M., Pastor-Sirvent, N., Santella, M., Ezquerra-Calvo, J., & Pérez-Merino, E. M. (2024). The impact of the transversus abdominis plane block (TAP) on stress response measured through the complete blood– derived inflammatory markers. Veterinary Research Communications, 48(1), 497–506. https://doi.org/10.1007/s11259-023-10234-7

Florettira, M. T., Manawan, E. E. U., & Subandrate, S. (2019). Profil Lipid Pasien Kolelitiasis Di Rsup Dr. Mohammad Hoesin Palembang. Sriwijaya University. https://repository.unsri.ac.id/23510/1/RAMA_11201_04011181621058_0016058404_01_front_ref.pdf

Gao, X., Zhang, L., Wang, S., Xiao, Y., Song, D., Zhou, D., & Wang, X. (2021). Prevalence, Risk Factors, and Complications of Cholelithiasis in Adults With Short Bowel Syndrome: A Longitudinal Cohort Study. Frontiers in Nutrition, 8, 762240. https://doi.org/10.3389/fnut.2021.762240

Hananta, I. P. Y., Vries, H. J. C. D., Dam, A. P. van, Rooijen, M. S. van, Soebono, H., & Loeff, M. F. S. van der. (2017). Persistence after treatment of pharyngeal gonococcal infections in patients of the STI clinic, Amsterdam, the Netherlands, 2012–2015: A retrospective cohort study. Sexually Transmitted Infections, 93(7), 467–471. https://doi.org/10.1136/sextrans-2017-053147

Hebbard, P. D., Barrington, M. J., & Vasey, C. (2010). Ultrasound-Guided Continuous Oblique Subcostal Transversus Abdominis Plane Blockade: Description of Anatomy and Clinical Technique. Regional Anesthesia & Pain Medicine, 35(5), 436–441. https://doi.org/10.1097/AAP.0b013e3181e66702

Jin, Z., Gan, T. J., & Bergese, S. D. (2020). Prevention and Treatment of Postoperative Nausea and Vomiting (PONV): A Review of Current Recommendations and Emerging Therapies. Therapeutics and Clinical Risk Management, 16, 1305–1317. https://doi.org/10.2147/TCRM.S256234

Kamarajah, S. K., Karri, S., Bundred, J. R., Evans, R. P. T., Lin, A., Kew, T., Ekeozor, C., Powell, S. L., Singh, P., & Griffiths, E. A. (2020). Perioperative outcomes after laparoscopic cholecystectomy in elderly patients: A systematic review and meta-analysis. Surgical Endoscopy, 34(11), 4727–4740. https://doi.org/10.1007/s00464-020-07805-z

Khan, K. K., & Khan, R. I. (2018). Analgesic Effect Of Bilateral Subcostal Tap Block After Laparoscopic Cholecystectomy. Journal of Ayub Medical College Abbottabad, 30(1), Article 1.

Kurmi, R. N., Mishra, R. K., Bhattarai, A., Chaudhary, P. K., Dhungana, T., Kafle, P. K., Yadav, G. K., & Subedee, A. (2023). Profile Of Laparoscopic Cholecystectomy: A Cross-Sectional Study From Tertiary Centre Of Central Nepal. Journal of Chitwan Medical College, 13(2), Article 2. https://doi.org/10.54530/jcmc.1239

Lazarchuk, I., Barzak, B., Wozniak, S., Mielczarek, A., & Lazarchuk, V. (2023). Cholelithiasis – a particular threat to women. A review of risk factors. Medical Journal of Cell Biology, 11(1), 20–27.

Li, Y.-D., Ren, Z.-J., Gao, L., Ma, J.-H., Gou, Y.-Q., Tan, W., & Liu, C. (2022). Cholelithiasis increased prostate cancer risk: Evidence from a case–control study and a meta-analysis. BMC Urology, 22(1), 160. https://doi.org/10.1186/s12894-022-01110-8

Li, Z., Chu, J., Su, F., Ding, X., Zhang, Y., Dou, L., Liu, Y., Ke, Y., Liu, X., Liu, Y., Wang, G., Wang, L., & He, S. (2022). Characteristics of bile microbiota in cholelithiasis, perihilar cholangiocarcinoma, distal cholangiocarcinoma, and pancreatic cancer. American Journal of Translational Research, 14(5), 2962–2971.

Majumder, A., Altieri, M. S., & Brunt, L. M. (2020). How do I do it: Laparoscopic cholecystectomy. Annals of Laparoscopic and Endoscopic Surgery, 5(0), Article 0. https://doi.org/10.21037/ales.2020.02.06

Otutaha, B., MacFater, W. S., Xia, W., Barazanchi, A. W. H., Autagavaia, V., & Hill, A. G. (2020). Intraperitoneal Tramadol in Abdominal Surgery: A Systematic Review. Journal of Surgical Research, 247, 406–412. https://doi.org/10.1016/j.jss.2019.10.002

Ozdemir, H., Araz, C., Karaca, O., & Turk, E. (2022). Comparison of Ultrasound-Guided Erector Spinae Plane Block and Subcostal Transversus Abdominis Plane Block for Postoperative Analgesia after Laparoscopic Cholecystectomy: A Randomized, Controlled Trial. Journal of Investigative Surgery, 35(4), 870–877. https://doi.org/10.1080/08941939.2021.1931574

Petersen, P. L., Hilsted, K. L., Dahl, J. B., & Mathiesen, O. (2013). Bilateral transversus abdominis plane (TAP) block with 24 hours ropivacaine infusion via TAP catheters: A randomized trial in healthy volunteers. BMC Anesthesiology, 13(1), 30. https://doi.org/10.1186/1471-2253-13-30

Reitano, E., de’Angelis, N., Schembari, E., Carrà, M. C., Francone, E., Gentilli, S., & La Greca, G. (2021). Learning curve for laparoscopic cholecystectomy has not been defined: A systematic review. ANZ Journal of Surgery, 91(9), E554–E560. https://doi.org/10.1111/ans.17021

Sani, M. A., Sani, D., Khan, F., Emmanuel, E. G., Muhammad, S. T., & Bada, A. A. (2022). Comparative evaluation of thiopental sodium and ketamine hydrochloride in the maintenance of general anaesthesia during exploratory laparotomy in Nigerian indigenous dogs. Sahel Journal of Veterinary Sciences, 19(2), Article 2.

Singla, S., Mittal, G., Raghav, & Mittal, R. K. (2014). Pain Management after Laparoscopic Cholecystectomy-A Randomized Prospective Trial of Low Pressure and Standard Pressure Pneumoperitoneum. Journal of Clinical and Diagnostic Research?: JCDR, 8(2), 92–94. https://doi.org/10.7860/JCDR/2014/7782.4017

Tihan, D., Totoz, T., Tokocin, M., Ercan, G., Calikoglu, T. K., Vartanoglu, T., Celebi, F., Dandin, O., & Kafa, I. M. (2016). Efficacy of laparoscopic transversus abdominis plane block for elective laparoscopic cholecystectomy in elderly patients. Bosnian Journal of Basic Medical Sciences, 16(2), 139–144. https://doi.org/10.17305/bjbms.2015.841

Tolchard, S., Davies, R., & Martindale, S. (2012). Efficacy of the subcostal transversus abdominis plane block in laparoscopic cholecystectomy: Comparison with conventional port-site infiltration. Journal of Anaesthesiology Clinical Pharmacology, 28(3), 339. https://doi.org/10.4103/0970-9185.98331

Tsai, P.-L., Lin, Y.-W., Chen, J.-S., Wu, S.-I., Chiang, M.-F., & Chen, M.-J. (2023). Cholelithiasis, cholecystitis, cholecystectomy and the associated risk of colorectal cancer. Formosan Journal of Surgery, 56(4), 109. https://doi.org/10.1097/FS9.0000000000000047

Wang, C.-C., Tseng, M.-H., Wu, S.-W., Yang, T.-W., Chen, H.-Y., Sung, W.-W., Su, C.-C., Wang, Y.-T., Chen, W.-L., Lai, H.-C., Lin, C.-C., & Tsai, M.-C. (2021). Symptomatic cholelithiasis patients have an increased risk of pancreatic cancer: A population-based study. Journal of Gastroenterology and Hepatology, 36(5), 1187–1196. https://doi.org/10.1111/jgh.15234

Wang, L., Chen, J., Jiang, W., Cen, L., Pan, J., Yu, C., Li, Y., Chen, W., Chen, C., & Shen, Z. (2021). The Relationship between Helicobacter pylori Infection of the Gallbladder and Chronic Cholecystitis and Cholelithiasis: A Systematic Review and Meta-Analysis. Canadian Journal of Gastroenterology and Hepatology, 2021, e8886085. https://doi.org/10.1155/2021/8886085

Weheba, H., Abdelsalam, T., Ghareeb, S., & Makharita, M. Y. (2019). Posterior quadratus lumborum block versus subcostal transversus abdominis plane block in laparoscopic cholecystectomy. Int J Anesthetic Anesthesiol, 6, 093.

Yang, M., Xia, B., Lu, Y., He, Q., Lin, Y., Yue, P., Bai, B., Dong, C., Meng, W., Qi, J., & Yuan, J. (2022). Association Between Regular Use of Gastric Acid Suppressants and Subsequent Risk of Cholelithiasis: A Prospective Cohort Study of 0.47 Million Participants. Frontiers in Pharmacology, 12, 813587. https://doi.org/10.3389/fphar.2021.813587

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Published

2024-08-30

How to Cite

Wardani, D. K. ., Sidemen, I. ., Hartawan , I. U. ., Widnyana, I. M. G. ., Parami, P. ., EM, T. A. ., Wiryana, M. ., & Senapathi, T. G. A. . (2024). PERBANDINGAN EFEKTIVITAS ANALGESIA PASCAOPERASI BLOK SUBKOSTAL TRANSVERSUS ABDOMINIS (STA) DENGAN OPIOID INTRAVENA PADA PASIEN OPERASI LAPAROSKOPI KOLESISTEKTOMI DI RSUP PROF. DR. I.G.N.G. NGOERAH DENPASAR. PREPOTIF : JURNAL KESEHATAN MASYARAKAT, 8(1), 2579–2593. https://doi.org/10.31004/prepotif.v8i1.27260

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