THE EFFECT OF NUTRITIONAL INTERVENTIONS ON THE SUCCESS TREATMENT OF TUBERCULOSIS IN CHILDREN: LITERATURE REVIEW
DOI:
https://doi.org/10.31004/prepotif.v7i3.20058Keywords:
children, nutritional intervention, treatment outcome, tuberculosisAbstract
ABSTRACT The incidence of tuberculosis in children is increasing and becomes a serious health problem because it can cause long-term effects such as death. TB can cause nutrient deficiencies and metabolic changes that delay recovery by suppressing immune function. Nutritional support is known to promote recovery in subjects treated for TB. The purpose of this study was to determine the effect of nutritional interventions on the success of childhood tuberculosis treatment. Literature review with 3 databases as literature search that are Pubmed, Proquest, Ebsco with analysis conducted using PRISMA. Five research articles were obtained from 3 databases relevant to the topic. Tuberculosis infection causes anorexia, malabsorption of nutrients and metabolic disorders, also causing malnutrition characterized by a decrease in fat and muscle mass. Malnutrition can be addressed with nutritional interventions that can be provided in the form of macronutient (high-protein diet) and micronutrients (vitamins and minerals). The combination of macronutrients and micronutrients can increase BMI, albumin levels, and improve fever and cough resolution. This can increase the ability of the child's immune response so that it can accelerate the recovery of children with TB. Improvement of nutrition in children is also supported by nutritional counseling that given to parents. Macronutrients and micronutrients are one of the factors supporting the success of TB treatment in children. Research on nutrition interventions is not enough, so it needs to be supported by further research on this topic so that it can provide better TB treatment results. ABSTRAK Angka kejadian tuberkulosis pada anak semakin meningkat dan menjadi masalah kesehatan yang serius karena dapat menimbulkan dampak jangka panjang seperti kematian. Tuberkulosis dapat menyebabkan defisiensi nutrisi dan perubahan metabolisme yang menunda pemulihan dengan menekan fungsi kekebalan tubuh. Dukungan nutrisi diketahui mampu mendorong pemulihan pada subjek yang mendapatkan pengobatan TB. Tujuan penelitian ini adalah untuk mengetahui pengaruh intervensi gizi terhadap keberhasilan pengobatan tuberkulosis anak. Kajian literatur dengan 3 database sebagai pencarian literatur yaitu Pubmed, Proquest, Ebsco dengan analisis dilakukan menggunakan PRISMA. Lima artikel penelitian diperoleh dari 3 database yang relevan dengan topik. Infeksi tuberkulosis menyebabkan anoreksia, malabsorbsi nutrisi dan gangguan metabolisme, juga menyebabkan malnutrisi yang ditandai dengan penurunan massa lemak dan otot. Gizi buruk dapat diatasi dengan intervensi gizi yang dapat diberikan dalam bentuk makronutrien (diet tinggi protein) dan mikronutrien (vitamin dan mineral). Kombinasi makronutrien dan mikronutrien dapat meningkatkan BMI, kadar hemoglobin, dan memperbaiki resolusi demam dan batuk. Hal ini dapat meningkatkan kemampuan respon imun anak sehingga dapat mempercepat pemulihan anak penderita TBC. Perbaikan gizi pada anak juga didukung dengan penyuluhan gizi yang diberikan kepada orang tua. Makronutrien dan Mikronutrien merupakan salah satu faktor pendukung keberhasilan pengobatan tuberkulosis pada anak-anak. Penelitian terkait intervensi gizi belum cukup banyak, sehingga perlu didukung dengan penelitian lebih lanjut, sehingga dapat memberikan hasil pengobatan TB yang lebih baik.References
Armijos, R. X., Weigel, M. M., Chacon, R., Flores, L., & Campos, A. (2010). Adjunctive micronutrient supplementation for pulmonary tuberculosis. Salud Pública de México, 52(3), 185–189. https://doi.org/10.1590/S0036-36342010000300001
Aulia Husna, C., Fitry Yani, F., & Masri, M. M. (2016). Gambaran Status Gizi Pasien Tuberkulosis Anak di RSUP Dr. M. Djamil Padang. Jurnal Kesehatan Andalas, 5(1). https://doi.org/10.25077/jka.v5i1.474
Carvalho, A. C. C., & Kritski, A. L. (2022). What is the global burden of tuberculosis among children? The Lancet Global Health, 10(2), e159–e160. https://doi.org/10.1016/S2214-109X(21)00548-9
Fabbri, A., Infante, M, & Ricordi, C. (2020). Editorial – Vitamin D status: A key modulator of innate immunity and natural defense from acute viral respiratory infections. Eur Rev Med Pharmacol Sci., 25.
Gupta, K. B., Gupta, R., Atreja, A., Verma, M., & Vishvkarma, S. (2009). Tuberculosis and nutrition. Lung India, 26(1).
Haerana, Bs. T., Prihartono, N. A., Riono, P., Djuwita, R., Syarif, S., Hadi, E. N., & Kaswandani, N. (2021). Prevalence of tuberculosis infection and its relationship to stunting in children (under five years) household contact with new tuberculosis cases. Indian Journal of Tuberculosis, 68(3), 350–355. https://doi.org/10.1016/j.ijtb.2020.10.011
Hood, M. L. H. (2013). A narrative review of recent progress in understanding the relationship between tuberculosis and protein energy malnutrition. European Journal of Clinical Nutrition, 67(11), 1122–1128. https://doi.org/10.1038/ejcn.2013.143
Hutasuhut, F. (2013). Effect of tempeh dates biscuits on nutritional status of preschool children with tuberculosis. Malaysian Journal of Nutrition, 19, 173–184.
Jaganath, D., & Mupere, E. (2012). Childhood Tuberculosis and Malnutrition. Journal of Infectious Diseases, 206(12), 1809–1815. https://doi.org/10.1093/infdis/jis608
Khalid, S. (2021). The Effect of Nutrition Education on Nutritional Status of Tuberculosis Patients. Biomedical Journal of Scientific & Technical Research, 33(3). https://doi.org/10.26717/BJSTR.2021.33.005391
Lodha, R., Mukherjee, A., Singh, V., Singh, S., Friis, H., Faurholt-Jepsen, D., Bhatnagar, S., Saini, S., Kabra, S. K., & Grewal, H. M. (2014). Effect of micronutrient supplementation on treatment outcomes in children with intrathoracic tuberculosis: A randomized controlled trial. The American Journal of Clinical Nutrition, 100(5), 1287–1297. https://doi.org/10.3945/ajcn.113.082255
Mehta, S., Mugusi, F. M., Bosch, R. J., Aboud, S., Chatterjee, A., Finkelstein, J. L., Fataki, M., Kisenge, R., & Fawzi, W. W. (2011). A randomized trial of multivitamin supplementation in children with tuberculosis in Tanzania. Nutrition Journal, 10(1), 120. https://doi.org/10.1186/1475-2891-10-120
Paton, N. I., Chua, Y.-K., Earnest, A., & Chee, C. B. (2004). Randomized controlled trial of nutritional supplementation in patients with newly diagnosed tuberculosis and wasting. The American Journal of Clinical Nutrition, 80(2), 460–465. https://doi.org/10.1093/ajcn/80.2.460
Patti, G., Pellegrino, C., Ricciardi, A., Novara, R., Cotugno, S., Papagni, R., Guido, G., Totaro, V., De Iaco, G., Romanelli, F., Stolfa, S., Minardi, M. L., Ronga, L., Fato, I., Lattanzio, R., Bavaro, D. F., Gualano, G., Sarmati, L., Saracino, A., … Di Gennaro, F. (2021). Potential Role of Vitamins A, B, C, D and E in TB Treatment and Prevention: A Narrative Review. Antibiotics MDPI, 10(11), 1354. https://doi.org/10.3390/antibiotics10111354
Pratomo, I. P., & Burhan, E. (2012). Malnutrisi dan Tuberkulosis. Jurnal of The Indonesian Medical Association, 62(6).
Roswati, R., Ruhdiana, T., & Arfania, M. (2022). Literature Review Article: Faktor Hubungan Status Gizi Pada Penderita Tuberkulosis. Jurnal Pendidikan dan Konseling, 4(6).
Seneadza, N. A. H., Antwi, S., Yang, H., Enimil, A., Dompreh, A., Wiesner, L., Peloquin, C. A., Lartey, M., Lauzardo, M., & Kwara, A. (2021a). Effect of malnutrition on the pharmacokinetics of anti-TB drugs in Ghanaian children. The International Journal of Tuberculosis and Lung Disease?: The Official Journal of the International Union against Tuberculosis and Lung Disease, 25(1), 36–42. https://doi.org/10.5588/ijtld.20.0301
Seneadza, N. A. H., Antwi, S., Yang, H., Enimil, A., Dompreh, A., Wiesner, L., Peloquin, C. A., Lartey, M., Lauzardo, M., & Kwara, A. (2021b). Effect of malnutrition on the pharmacokinetics of anti-TB drugs in Ghanaian children. The International Journal of Tuberculosis and Lung Disease?: The Official Journal of the International Union against Tuberculosis and Lung Disease, 25(1), 36–42. https://doi.org/10.5588/ijtld.20.0301
Sinha, P., Davis, J., Saag, L., Wanke, C., Salgame, P., Mesick, J., Horsburgh, C. R., & Hochberg, N. S. (2019). Undernutrition and Tuberculosis: Public Health Implications. The Journal of Infectious Diseases, 219(9), 1356–1363. https://doi.org/10.1093/infdis/jiy675
Smuts, C. M., Lombard, C. J., Benadé, A. J. S., Dhansay, M. A., Berger, J., Hop, L. T., López De Romaña, G., Untoro, J., Karyadi, E., Erhardt, J., & Gross, R. (2005). Efficacy of a Foodlet-Based Multiple Micronutrient Supplement for Preventing Growth Faltering, Anemia, and Micronutrient Deficiency of Infants: The Four Country IRIS Trial Pooled Data Analysis,. The Journal of Nutrition, 135(3), 631S-638S. https://doi.org/10.1093/jn/135.3.631S
Sudana, I. M. (2017). Analisis Pengaruh Fase Pengobatan, Tingkat Depresi dan Konsumsi Makanan Terhadap Status Gizi Penderita Tuberkulosis (TB) Paru Di Wilayah Kerja Puskesmas se- Kecamatan Genuk Kota Semarang. Public Health Perspective Journal, 2(3).
Tamara, L., Kartasasmita, C. B., Alam, A., & Gurnida, D. A. (2022). Effects of Vitamin D supplementation on resolution of fever and cough in children with pulmonary tuberculosis: A randomized double-blind controlled trial in Indonesia. Journal of Global Health, 12, 04015. https://doi.org/10.7189/jogh.12.04015
Taslim, N. A., Rasyid, H., Atmanegara, M. K., Angriavan, S., & Amelia, R. (2020). Effect of Chocolate Soybean Drink on Nutritional Status, Gamma Interferon, Vitamin D, and Calcium in Newly Lung Tuberculosis Patients | Open Access Macedonian Journal of Medical Sciences. Open Access Macedonian Journal of Medical Sciences, 8(T2), 210–214.
Tellez-Navarrete, N. A., Ramon-Luing, L. A., Muñoz-Torrico, M., Osuna-Padilla, I. A., & Chavez-Galan, L. (2021). Malnutrition and tuberculosis: The gap between basic research and clinical trials. The Journal of Infection in Developing Countries, 15(03), 310–319. https://doi.org/10.3855/jidc.12821
World Health Organization. (2022). Global Tuberculosis Report 2022. World Health Organization.
World Health Organization. (2022). WHO consolidated guidelines on tuberculosis. Module 5, Management of tuberculosis in children and adolescents. World Health Organization.
World Health Organization. (2023). Tuberculosis (TB). https://www.who.int/news-room/fact-sheets/detail/tuberculosis
Wulandari, P. S., & Karolina, M. E. (2023). The Relationship Between Treatment Phase And Nutritional Status In Adult Tuberculosis Patients At Public Health Centers In Jambi City. JMJ. 360-366.
Xiong, K., Wang, J., Zhang, J., Hao, H., Wang, Q., Cai, J., & Ma, A. (2020). Association of Dietary Micronutrient Intake with Pulmonary Tuberculosis Treatment Failure Rate: ACohort Study. Nutrients, 12(9), 2491. https://doi.org/10.3390/nu12092491
Yani, F. F., Lipoeto, N. I., Supriyatno, B., Darwin, E., & Basir, D. (2017). Vitamin D status in under-five children with a history of close tuberculosis contact in Padang, West Sumatra. Asia Pacific Journal of Clinical Nutrition, 26(Suppl 1), S68–S72. https://doi.org/10.6133/apjcn.062017.s2
Yayasan KNCV Indonesia. (2022). Apa Itu Tuberkulosis / TBC? Apa Itu Tuberkulosis / TBC? https://yki4tbc.org/tuberkulosis-tbc/
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Putri Ardhani, Puput Oktamianti, Novie Irawaty Laura Manurung
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work’s authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal’s published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).