POTENSI AKTIVITAS ANTIDIABETES DAUN KEMANGI (OCIMUM BASILICUM): LITERATURE REVIEW
DOI:
https://doi.org/10.31004/prepotif.v7i1.12975Keywords:
antidiabetes daun kemangi, diabetes mellitus, hiperglikemia, Ocimum basilicumAbstract
Diabetes melitus (DM) adalah penyakit metabolik kompleks yang ditandai dengan peningkatan kadar glukosa darah secara kronis akibat kelainan sekresi insulin, kerja insulin, atau keduanya. Prevalensi diabetes cenderung meningkat dari waktu ke waktu dan berkaitan erat dengan berbagai komplikasi mikrovaskular dan makrovaskular. Pemberian terapi farmakologis pada pasien diabetes masih menimbulkan beberapa masalah dan efek samping. Berdasarkan studi terbaru, pemberian ekstrak dari daun kemangi (Ocimum basilicum) pada model hewan coba diabetes dapat menurunkan kadar glukosa darah sehingga dapat membantu mengendalikan status glikemik. Terdapat enam studi mengenai potensi daun kemangi sebagai antidiabetes yang ditemukan dalam studi ini. Menggunakan metode literature review, pencarian studi dilakukan melalui online database berdasarkan kriteria inklusi dan eksklusi serta kata kunci yang telah ditetapkan. Berdasarkan studi yang terinklusi, pemberian daun kemangi (kebanyakan ekstrak) pada model hewan coba diabetes, dapat menurunkan kadar glukosa darah, meregenerasi sel ? pankreas, meningkatkan kerja hormon insulin, dan meningkatkan fungsi enzim antioksidan. Mekanisme antidiabetes daun kemangi bekerja melalui beberapa jalur seperti antioksidan, penginhibisi absorbsi karbohidrat di usus, PPAR-? signaling, NF-?B signaling, dan lain-lain. Potensi dan manfaat antidiabetes daun kemangi dalam mengendalikan status glikemik dibahas secara mendalam dalam studi ini.References
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