EVALUASI EFEKTIVITAS PENGENDALIAN TEKNIK (ENGINEERING CONTROL) PAJANAN ACTIVE PHARMACEUTICAL INGREDIENT (API) PADA PEKERJA DI PROSES PENIMBANGAN BAHAN BAKU OBAT PT. XY – STUDI KASUS PEMBUATAN TABLET OBAT DHASOLONE 5 mg

Authors

  • Mirza Defriandi Departemen Keselamatan dan Kesehatan Kerja, Fakultas Kesehatan Masyarakat, Universitas Indonesia
  • Doni Hikmat Ramdhan Departemen Keselamatan dan Kesehatan Kerja, Fakultas Kesehatan Masyarakat, Universitas Indonesia

DOI:

https://doi.org/10.31004/prepotif.v6i2.4387

Keywords:

Engineering Control, Active Pharmaceutical Ingredient (API), Occupational Exposure Band (OEB)

Abstract

Dampak kesehatan dapat menjadi ancaman pada pekerja di sektor industri farmasi karena potensi risiko terpajan debu Active Pharmaceutical Ingredient (API) pada konsentrasI tinggi yang merupakan bahan aktif obat yang bersifat senyawa kuat (potent) selama proses penimbangan bahan baku. Tujuan dari penelitian ini  melakukan evaluasi efektivitas pengendalian melalui rekayasa teknik (Engineering Control) dalam mengendalikan tingkat pajanan pada proses penimbangan menggunakan studi kasus pembuatan tablet obat Dhasolone 5 mg yang menggunakan API Prednisolone yang termasuk OEB (Occupational Exposure Band) 4. Sebanyak 3 sampel pajanan personal diambil sebagai data awal pajanan dan dilakukan analisis laboratorium untuk mengetahui nilai TWA – 8 jam (Time Weighted Average) dan dibandingkan dengan nilai OEL (Occupational Exposure Limit) API Prednisolone 9 µg/m3. Proses perbaikan pada lokasi penimbangan dilakukan melalui penerapan rekayasa pengendalian teknik dengan pemasangan Weighing Booth, dan dilakukan pengambilan sampel ulang pajanan personal sebanyak 3 sampel dan lingkungan sebanyak 5 titik di ruang penimbangan untuk melihat efektivitas pengendalian yang dilakukan. Hasil penelitian menunjukkan pemasangan unit Weighing Booth di lokasi penimbangan efektif mengendalikan risiko pajanan API pada pekerja dengan hasil akhir pengukuran pajanan personal rata-rata sebesar 0,440±6,72 µg/m3, dan hasil pengukuran pajanan lingkungan dengan rata-rata 0,451±4,81 µg/m3. Disimpulkan bahwa pengendalian pajanan melalui rekayasan teknik efektif mengurangi potensi risiko pajanan API pada pekerja di proses penimbangan bahan baku obat dari kategori pajanan 4 menjadi kategori pajanan 2

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Published

2023-12-20

How to Cite

Defriandi, M. ., & Ramdhan, D. H. . (2023). EVALUASI EFEKTIVITAS PENGENDALIAN TEKNIK (ENGINEERING CONTROL) PAJANAN ACTIVE PHARMACEUTICAL INGREDIENT (API) PADA PEKERJA DI PROSES PENIMBANGAN BAHAN BAKU OBAT PT. XY – STUDI KASUS PEMBUATAN TABLET OBAT DHASOLONE 5 mg. PREPOTIF : JURNAL KESEHATAN MASYARAKAT, 6(2), 1184–1191. https://doi.org/10.31004/prepotif.v6i2.4387

Issue

Vol. 6 No. 2 (2022): AGUSTUS 2022

Section

Articles

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Copyright (c) 2022 Mirza Defriandi, Doni Hikmat Ramdhan

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