PENGARUH PEMBERIAN EKSTRAK BERAS HITAM TERHADAP KADAR GLUKOSA DARAH MENCIT
DOI:
https://doi.org/10.31004/prepotif.v8i3.33450Keywords:
ekstrak beras hitam, hiperglikemia, kadar glukosa darah mencit (mus musculus)Abstract
Diabetes Melitus (DM) merupakan suatu gejala klinis yang ditandai dengan peningkatan glukosa darah plasma (hiperglikemia). Beras hitam memiliki aktivitas antioksidan dapat mengurangi stress oksidatif pada penderita diabetes melitus, sehingga antioksidan mampu mencegah komplikasi diabetes. Untuk mengetahui pengaruh pemberian ekstrak beras hitam terhadap kadar glukosa darah mencit dengan hiperglikemia. Penelitian kuantitatif eksperimental dengan eksperimental murni (true-experiment) rancangan penelitian pre and post test with control group design. Sampel penelitian dilakukan pada 30 ekor mencit (Mus musculus) dengan teknik simple random sampling. Analisa data dua tahap yaitu analisa univariat dan analisa bivariat uji statistik Chi Square. Kadar glukosa darah mencit dengan hiperglikemia yang diinduksi aloksan, sebelum perlakuan memiliki rata-rata 203,37g/dL. Kadar glukosa darah mencit dengan hiperglikemia yang diinduksi aloksan, setelah perlakuan mengalami penurunan dan memiliki rata-rata 135,22g/dL. Terdapat perbedaan selisih kadar glukosa darah antar kelompok sebelum perlakuan dan setelah perlakuan dengan nilai p-value sebesar 0,000 yang berarti dimana kelompok ekstrak beras hitam (Oryza sativa L. indica) mengalami penurunan kadar glukosa darah yang lebih besar daripada kelompok metformin. Ekstrak beras hitam mengandung antosianin yang dapat memperbaiki keadaan hiperglikemia dan sensitivitas insulin, ekstrak beras hitam dapat meningkatkan sensitivitas insulin dan menghambat kelebihan mukosa usus sehingga penyerapan glukosa dan fruktosa usus berkurang dan darah kembali normal.References
Ahrén, B. & Sundkvist, G. Long-term effects of alloxan in mice. Int. J. Pancreatol. Off. J. Int. Assoc. Pancreatol. 17, 197–201 (1995).
American Diabetes Association. Classification and Diagnosis of Diabetes. Diabetes Care 39, S13–S22 (2015).
Campos, C. Chronic hyperglycemia and glucose toxicity: pathology and clinical sequelae. Postgrad. Med. 124, 90–97 (2012).
Ch Kereh, B., Mayulu, N. & Kawengian, S. E. Gambaran Kandungan Zat- Zat Gizi Pada Beras Hitam (Oryza Sativa L.) Varietas Enrekang. eBiomedik 4, (2016).
Daeli, E., Ardiaria, M. & Candra, A. Pengaruh Pemberian Nasi Beras Merah (Oryza nivara) dan Nasi Beras Hitam (Oryza sativa L.indica) terhadap Perubahan Kadar Gula Darah dan Trigliserida Tikus Wistar (Rattus norvegicus) Diabetes Melitus Tipe 2. JNH (Journal Nutr. Heal. 6, 42–56 (2018)
Sam, Y., Kim, S.-J. & Chang, H. I. Isolation of anthocyanin from black rice (Heugjinjubyeo) and screening of its antioxidant activities. J. Microbiol. Biotechnol 36, 55–60 (2008).
Simon, K. & Wittmann, I. Can blood glucose value really be referred to as a metabolic parameter? Rev. Endocr. Metab. Disord. 20, 151–160 (2019).
Stevani, H. Modul Bahan Ajar Cetak Farmasi Praktikum Farmakologi. Badan Pengemb. dan Pemberdaya. Sumberd. Mns. Kesehatan. Kementeri. Kesehat. Republik Indones. (2016).
Tjitrosoepomo, G. Morphology Tumbuhan (Plant Morphology). (Gadjah Mada University Press, 2020).
WHO. Diabetes. World Health Organization https://www.who.int/news-room/fact-sheets/detail/diabetes (2021).
Yari, Z., Behrouz, V., Zand, H. & Pourvali, K. New Insight into Diabetes Management: From Glycemic Index to Dietary Insulin Index. Curr. Diabetes Rev. 16, 293–300 (2020).
Zhang, M. W., Zhang, R. F., Zhang, F. X. & Liu, R. H. Phenolic profiles and antioxidant activity of black rice bran of different commercially available varieties. J. Agric. Food Chem. 58, 7580–7587 (2010). Stock. Beras Hitam. https://www.istockphoto.com/id/foto/nasi-hitam-gm498424681-42315994
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Alfiyya Zahra Nizrina
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work’s authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal’s published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
