PERAN HORMON SEROTONIN DALAM FUNGSI MEMORI: SEBUAH STUDI LITERATUR

Authors

  • Fika Tri Anggraini Fakultas Kedokteran, Universitas Andalas

DOI:

https://doi.org/10.31004/prepotif.v7i1.14623

Keywords:

hormon serotonin, hidroksitriptamin, 5-HT, memori

Abstract

Fungsi memori menjadi masalah kesehatan yang menarik karena termasuk gangguan kognitif yang berhubungan yang menjadi masalah kesehatan di masyarakat. Hormon serotonin disintesis di neuron serotonergis di sistem saraf pusat dan memiliki fungsi kognitif termasuk memori. Hormon serotonin (5-hidroksitriptamin/ 5-HT) mengatur suasana hati, rasa nyeri, siklus tidur hingga memori. Tujuan: meninjau dan membahas hormon serotonin dalam fungsi memori. menggunakan studi literature review penelitian tahun 2019-2023 yang sudah terpublikasi di media elektronik seperti Science direct, ProQuest, CINAHL, Pubmed, dan google scholar. Jumlah artikel penelitian Randomized controlled trials (RCTs) yang diperoleh terdapat 8 artikel yang memenuhi kriteria. Subjek penelitian adalah hormon serotonin. Hasil penelitian yang diperoleh bahwa peran hormon serotonin sangat penting dalam fungsi memori, kadar serotonin yang rendah mengakibatkan kelemahan dalam menyimpan memori. Neurotransmiter pada hormon serotonin baik secara langsung maupun tidak langsung terlibat dalam proses penyimpanan memori, sehingga penting agar dapat meningkatkan kadar serotonin dalam tubuh dalam batas nilai normal.

References

Alghadir, A. H., Gabr, S. A., & Iqbal, Z. A. (2020). Effect of gender, physical activity and stress-related hormones on adolescent’s academic achievements. International Journal of Environmental Research and Public Health, 17(11). https://doi.org/10.3390/ijerph17114143

Ali, S. B., Mahmood, K., Saeed, R., Salman, T., Choudhary, M. I., & Haleem, D. J. (2021). Elevated anxiety, hypoactivity, memory deficits, decreases of brain serotonin and 5-HT-1A receptors expression in rats treated with omeprazole. Toxicological Research, 37(2). https://doi.org/10.1007/s43188-020-00060-3

Bacqué-cazenave, J., Bharatiya, R., Barrière, G., Delbecque, J. P., Bouguiyoud, N., Di Giovanni, G., Cattaert, D., & De Deurwaerdère, P. (2020). Serotonin in animal cognition and behavior. In International Journal of Molecular Sciences (Vol. 21, Issue 5). https://doi.org/10.3390/ijms21051649

Bostanc?kl?o?lu, M. (2020). Optogenetic stimulation of serotonin nuclei retrieve the lost memory in Alzheimer’s disease. In Journal of Cellular Physiology (Vol. 235, Issue 2). https://doi.org/10.1002/jcp.29077

Coray, R., & Quednow, B. B. (2022). The role of serotonin in declarative memory: A systematic review of animal and human research. In Neuroscience and Biobehavioral Reviews (Vol. 139). https://doi.org/10.1016/j.neubiorev.2022.104729

Feduccia, A. A., & Mithoefer, M. C. (2018). MDMA-assisted psychotherapy for PTSD: Are memory reconsolidation and fear extinction underlying mechanisms? In Progress in Neuro-Psychopharmacology and Biological Psychiatry (Vol. 84). https://doi.org/10.1016/j.pnpbp.2018.03.003

Forero, A., Ku, H. P., Malpartida, A. B., Wäldchen, S., Alhama-Riba, J., Kulka, C., Aboagye, B., Norton, W. H. J., Young, A. M. J., Ding, Y. Q., Blum, R., Sauer, M., Rivero, O., & Lesch, K. P. (2020). Serotonin (5-HT) neuron-specific inactivation of Cadherin-13 impacts 5-HT system formation and cognitive function. Neuropharmacology, 168. https://doi.org/10.1016/j.neuropharm.2020.108018

Haleem, D. J., & Mahmood, K. (2021). Brain serotonin in high-fat diet-induced weight gain, anxiety and spatial memory in rats. Nutritional Neuroscience, 24(3). https://doi.org/10.1080/1028415X.2019.1619983

John Jayakumar, J. A. K., & Panicker, M. M. (2021). The roles of serotonin in cell adhesion and migration, and cytoskeletal remodeling. In Cell Adhesion and Migration (Vol. 15, Issue 1). https://doi.org/10.1080/19336918.2021.1963574

Kanen, J. W., Arntz, F. E., Yellowlees, R., Christmas, D. M., Price, A., Apergis-Schoute, A. M., Sahakian, B. J., Cardinal, R. N., & Robbins, T. W. (2021). Effect of Tryptophan Depletion on Conditioned Threat Memory Expression: Role of Intolerance of Uncertainty. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 6(5). https://doi.org/10.1016/j.bpsc.2020.12.012

Kanova, M., & Kohout, P. (2021). Serotonin—its synthesis and roles in the healthy and the critically ill. In International Journal of Molecular Sciences (Vol. 22, Issue 9). https://doi.org/10.3390/ijms22094837

Pourhamzeh, M., Moravej, F. G., Arabi, M., Shahriari, E., Mehrabi, S., Ward, R., Ahadi, R., & Joghataei, M. T. (2022). The Roles of Serotonin in Neuropsychiatric Disorders. In Cellular and Molecular Neurobiology (Vol. 42, Issue 6). https://doi.org/10.1007/s10571-021-01064-9

Primadona, E., Pudjonarko, D., Rahmawati, D., Kustiowati, E., Suryawati, H., & Budisulystio, T. (2020). Hubungan Antara Kadar Serotonin Serum dengan Fungsi Kognitif pada Pasien Nyeri Kepala Tipe Tegang Kronis. Neurona, 38(1), 1–7. https://www.neurona.web.id/paper-detail.do?id=1202

Sengupta, A., & Holmes, A. (2019). A Discrete Dorsal Raphe to Basal Amygdala 5-HT Circuit Calibrates Aversive Memory. Neuron, 103(3). https://doi.org/10.1016/j.neuron.2019.05.029

Siotto, M., Germanotta, M., Santoro, M., Cipollini, V., Guardati, G., Papadopoulou, D., Bray, E., Mastrorosa, A., & Aprile, I. (2021). Serotonin levels and cognitive recovery in patients with subacute stroke after rehabilitation treatment. Brain Sciences, 11(5). https://doi.org/10.3390/brainsci11050642

?lifirski, G., Król, M., & Tur?o, J. (2021). 5-HT receptors and the development of new antidepressants. In International Journal of Molecular Sciences (Vol. 22, Issue 16). https://doi.org/10.3390/ijms22169015

Ubuka, T. (2021). Serotonin. Handbook of Hormones: Comparative Endocrinology for Basic and Clinical Research. https://doi.org/10.1016/B978-0-12-820649-2.00292-8

Vaseghi, S., Arjmandi-Rad, S., Eskandari, M., Ebrahimnejad, M., Kholghi, G., & Zarrindast, M. R. (2022). Modulating role of serotonergic signaling in sleep and memory. In Pharmacological Reports (Vol. 74, Issue 1). https://doi.org/10.1007/s43440-021-00339-8

Waider, J., Popp, S., Mlinar, B., Montalbano, A., Bonfiglio, F., Aboagye, B., Thuy, E., Kern, R., Thiel, C., Araragi, N., Svirin, E., Schmitt-Böhrer, A. G., Corradetti, R., Lowry, C. A., & Lesch, K. P. (2019). Serotonin deficiency increases context-dependent fear learning through modulation of hippocampal activity. Frontiers in Neuroscience, 13(APR). https://doi.org/10.3389/fnins.2019.00245

Wu, X., Morishita, W., Beier, K. T., Heifets, B. D., & Malenka, R. C. (2021). 5-HT modulation of a medial septal circuit tunes social memory stability. Nature, 599(7883). https://doi.org/10.1038/s41586-021-03956-8

Yu, W., Yen, Y. C., Lee, Y. H., Tan, S., Xiao, Y., Lokman, H., Ting, A. K. T., Ganegala, H., Kwon, T., Ho, W. K., & Je, H. S. (2019). Prenatal selective serotonin reuptake inhibitor (SSRI) exposure induces working memory and social recognition deficits by disrupting inhibitory synaptic networks in male mice. Molecular Brain, 12(1). https://doi.org/10.1186/s13041-019-0452-5

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Published

2023-12-20

How to Cite

Tri Anggraini, F. (2023). PERAN HORMON SEROTONIN DALAM FUNGSI MEMORI: SEBUAH STUDI LITERATUR. PREPOTIF : JURNAL KESEHATAN MASYARAKAT, 7(1), 1541–1546. https://doi.org/10.31004/prepotif.v7i1.14623

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