Analisis Pengaruh dan Optimalisasi Nilai Full Width At Half Maximum (Fwhm) Terhadap Spektrum Metabolit Metode Multi-Voxel Magnetic Resonance Spectroscopy (Mrs)
DOI:
https://doi.org/10.31004/jn.v9i3.47221Abstract
Full Width at Half Maximum (FWHM) merupakan indikator penting dalam Magnetic Resonance Spectroscopy (MRS) karena memengaruhi kualitas spektrum metabolit dan berpengaruh terhadap akurasi kuantifikasi metabolit. Hingga saat ini belum diketahui secara pasti rentang nilai FWHM optimal untuk metode multi voxel. Tujuan penelitian ini menganalisis pengaruh variasi nilai FWHM terhadap spektrum metabolit serta menentukan nilai FWHM optimal untuk memperoleh spektrum dengan kualitas terbaik. Sampel penelitian sebanyak 12 pasien MRS brain menggunakan MRI 1,5T dengan variasi FWHM (10–14 Hz, 15–18 Hz, 20–22 Hz, dan 23–25 Hz). Nilai integral metabolit N-Acetyl Aspartate (NAA), Creatine (Cr), dan Choline (Cho) dianalisis menggunakan uji Shapiro-Wilk, Levene’s test, One-Way ANOVA, dan Kruskal-Wallis. Wawancara terhadap observer untuk mengetahui pengaruh FWHM terhadap spektrum. Hasil menunjukkan bahwa variasi nilai FWHM tidak memberikan pengaruh signifikan terhadap nilai integral NAA (p = 0,993), Cr (p = 0,399), dan Cho (p = 0,492). Namun, berdasarkan hasil uji statistik deskriptif nilai integral metabolit, rentang FWHM 15–18 Hz memberikan hasil spektrum yang lebih stabil. Meskipun tidak signifikan secara statistik terhadap nilai integral metabolit, rentang FWHM 15–18 Hz direkomendasikan sebagai nilai optimal untuk memperoleh kualitas spektrum terbaik pada MRS multi voxel.
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Published
2025-07-03
How to Cite
Fannisa Rahma Pradika, Rahardian, A. P., Utami, H. S., Fitriana, L., & Susilowati, P. (2025). Analisis Pengaruh dan Optimalisasi Nilai Full Width At Half Maximum (Fwhm) Terhadap Spektrum Metabolit Metode Multi-Voxel Magnetic Resonance Spectroscopy (Mrs). Jurnal Ners, 9(3), 4846–4853. https://doi.org/10.31004/jn.v9i3.47221
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