POTENSI TERAPEUTIK TANAMAN PACE (Morinda citrifolia L.) SEBAGAI HERBAL MULTIFUNGSI : SYSTEMATIC LITERATURE REVIEW

Authors

  • Rizki Amandani Program Studi S1 Farmasi, Fakultas Farmasi, Sains, dan Teknologi, Universitas Al-Irsyad Cilacap, Program Studi Pendidikan Profesi Apoteker, Fakultas, Farmasi, Sains dan Teknologi, Universitas Al-Irsyad Cilacap
  • Nikmah Nuur Rochmah Program Studi S1 Farmasi, Fakultas Farmasi, Sains, dan Teknologi, Universitas Al-Irsyad Cilacap, Program Studi Pendidikan Profesi Apoteker, Fakultas, Farmasi, Sains dan Teknologi, Universitas Al-Irsyad Cilacap
  • Yuhansyah Nur Fauzi Program Studi S1 Farmasi, Fakultas Farmasi, Sains, dan Teknologi, Universitas Al-Irsyad Cilacap, Program Studi Pendidikan Profesi Apoteker, Fakultas, Farmasi, Sains dan Teknologi, Universitas Al-Irsyad Cilacap

DOI:

https://doi.org/10.31004/jkt.v7i1.54830

Keywords:

aktivitas farmakologis, herbal multifungsi, Morinda citrifolia L, tanaman pace

Abstract

Penggunaan tanaman pace sebagai herbal multifungsi masih menghadapi berbagai kendala seperti variasi hasil penelitian, banyaknya fokus pada studi pra-klinis, serta kurangnya sintesis ilmiah. Penelitian ini bertujuan untuk mengevaluasi secara sistematis aktivitas farmakologis, kandungan fitokimia, metode ekstraksi, dan potensi terapeutik tanaman pace berdasarkan bukti ilmiah terkini metode yang digunakan adalah Systematic Literature Review (SLR) dengan pedoman PRISMA 2020, meliputi tahap identifikasi, skrining, penilaian kelayakan, dan inklusi artikel. Pencarian literatur dilakukan melalui database Scopus, PubMed, dan Google Scholar menggunakan kata kunci ("Morinda citrifolia" OR "pharmacological) AND ("therapeutic" OR "bioactive compounds") terhadap 10 artikel yang memenuhi syarat terdiri dari 3 in vivo, 3 in vitro, 2 eksperimental fitokimia, 2 eksperimental terapan dengan penyebaran negara antara lain Arab Saudi, Indonesia, Korea Selatan, India, Jepang, Brazil, dan Cina, diterbitkan antara tahun 2016–2026. Hasil analisis literatur menunjukkan bahwa buah, daun, dan biji pace mengandung senyawa bioaktif seperti iridoid, flavonoid, polifenol, skopoletin, dan polisakarida. Senyawa tersebut memiliki manfaat farmakologis, antara lain: menangkal radikal bebas, mengurangi peradangan, membantu pengendalian diabetes, meningkatkan daya tahan tubuh. Kesimpulannya berdasarkan bukti terkini, tanaman pace memiliki potensi terapeutik signifikan sebagai herbal multifungsi. Namun, untuk memastikan efektivitas dan keamanan penggunaannya secara medis, diperlukan penelitian lanjutan dengan uji klinis yang ketat serta standarisasi produk herbal.  

References

Abou Assi, R., Darwis, Y., Abdulbaqi, I. M., khan, A. A., Vuanghao, L., & Laghari, M. H. (2017). Morinda citrifolia (Noni): A comprehensive review on its industrial uses, pharmacological activities, and clinical trials. Arabian Journal of Chemistry, 10(5), 691–707. https://doi.org/https://doi.org/10.1016/j.arabjc.2015.06.018

Cao, T. Q., Eom, H., Kim, H., Kang, H. Y., Park, Y. M., Jung, S. K., & Hahn, D. (2025). Inhibitory Effects of Compounds Isolated from Morinda citrifolia L. (Noni) Seeds against Particulate Matter-Induced Injury. Journal of Microbiology and Biotechnology, 35. https://doi.org/10.4014/jmb.2407.07062

Chanthira Kumar, H., Lim, X. Y., Mohkiar, F. H., Suhaimi, S. N., Mohammad Shafie, N., & Chin Tan, T. Y. (2022). Efficacy and Safety of Morinda citrifolia L. (Noni) as a Potential Anticancer Agent. Integrative Cancer Therapies, 21, 15347354221132848. https://doi.org/10.1177/15347354221132848

Chellappa, L. R., & Doraikannan, S. (2022). Morinda citrifolia mediated biogenic synthesis of selenium nanoparticles and evaluation of its antimicrobial and antioxidant activity. International Journal of Health Sciences, 2475–2486. https://doi.org/10.53730/ijhs.v6nS1.5312

Dewi, R., Siregar, T. N., Sutriana, A., & Wahyuni, S. (2025). Antioxidant and Molecular Docking of Morinda citrifolia Leaves Extract as an Alternative Infertility Treatment. Journal of Human, Earth, and Future. https://doi.org/10.28991/HEF-2025-06-03-08

Dewi, R. T., Angelina, M., Fajriah, S., Sukirno, Yolanda, T., & Ernawati, T. (2022). SCOPOLETIN AS A MARKER COMPOUND FROM FERMENTED Morinda citrifolia FRUITS EXTRACT: POTENTIAL α-GLUCOSIDASE INHIBITOR AND ANTIOXIDANT COMPOUNDS. Rasayan Journal of Chemistry, 15(3.0), 1588–1595. https://doi.org/10.31788/RJC.2022.1536666

Dumiri, R., Kep, M. S., & Biomed, M. (2024). Editor : La Ode Alifariki , S . Kep ., Ns ., M . Kes.

Fontes, R. F., Andrade, J. K. S., Rajan, M., & Narain, N. (2023). Chemical characterization of different parts of noni (Morinda citrifolia) fruit and its freeze-dried pulp powder with emphasis on its bioactive compounds and antioxidant activities. Food Science and Technology (Brazil), 43. https://doi.org/10.1590/fst.103722

Hou, S., Ma, D., Wu, S., Hui, Q., & Hao, Z. (2025). Morinda citrifolia L.: A Comprehensive Review on Phytochemistry, Pharmacological Effects, and Antioxidant Potential. Antioxidants. https://doi.org/10.3390/antiox14030295

Indrianingsih, A. W., Khasanah, Y., Darsih, C., Hastuti, H. P., Suryani, A. E., Suwanda, N. U., Cahyono Murti, S. T., Windarsih, A., Wiyono, T., Rahayu, E., Purwaningsih, H., Ni’maturrohmah, D., Noviana, E., & Tjokrokusumo, D. (2025). Formulation, physicochemical properties, antioxidant and antidiabetic activity of Morinda citrifolia L. extract-fortified purple yam (Dioscorea alata) cookies. Bioactive Carbohydrates and Dietary Fibre. https://doi.org/10.1016/j.bcdf.2025.100503

Indriyana, W. M., Chodidjah, C., & Sumarawati, T. (2025). The Effect of Noni (Morinda citrifolia) Extract Gel on Collagen Density and Expression of p53 Protein in Rats Exposed to UVB. Tropical Journal of Natural Product Research, 9(1.0), 204–208. https://doi.org/10.26538/tjnpr/v9i1.30

Kamri, A., Ningsih, R., & Amirah, S. (2022). The Hepatoprotective Effects of Ethanolic Extract Noni Fruits (Morinda citrifolia L.) on Rats (Rattus norvegicus) Liver with SGPT and Histopathological Evaluations. European Journal of Veterinary Medicine, 2, 15–19. https://doi.org/10.24018/ejvetmed.2022.2.3.26

Kongpuckdee, S., Phadoongsombut, N., Ardhanwanich, S., & Mahattanadul, S. (2024). Role of Scopoletin Containing in an Aqueous Morinda citrifolia Fruit Extract on the Gastric Mucosal Integrity and Gastric Ulcer Healing Process. Letters in Applied NanoBioScience, 13(4.0). https://doi.org/10.33263/LIANBS134.160

Landari, I., Kusumawati, I. G. A., Wayan, N., & agung yogeswara, I. (2023). PROFIL SENYAWA FLAVONOID EKSTRAK BUAH MENGKUDU (Morinda citrifolia L.) DENGAN BERBAGAI METODE PENGERINGAN. Jurnal Teknologi Pertanian Andalas, 27, 7. https://doi.org/10.25077/jtpa.27.1.7-16.2023

Li, C.-H., Huang, Y.-X., Duan, Y., Liu, G.-P., Ai, Z.-W., Ai, Z.-F., Li, J., & Li, S.-X. (2025). Morinda citrifolia L. (noni) and its potential in the management of systemic metabolic disorder (SMD). Food and Function. https://doi.org/10.1039/d5fo03892h

Liu, D., Tang, W., Zhang, G., Chen, X., Wu, Y., Tang, J., Xia, H., & Wen, M. (2025). Morinda citrifolia (noni) polysaccharides: Extraction methods, molecular structures, and biological activities. International Journal of Biological Macromolecules. https://doi.org/10.1016/j.ijbiomac.2025.147315

Manetti, F. (2018). Recent advances in the rational design and development of LIM kinase inhibitors are not enough to enter clinical trials. European Journal of Medicinal Chemistry, 155, 445–458. https://doi.org/https://doi.org/10.1016/j.ejmech.2018.06.016

Nascimento Júnior, J. A. C., Santos, A. M., Oliveira, A. M. S., Santana Júnior, C. C., Serafini, M. R., Quintans, J. de S. S., Picot, L., de Menezes, I. R. A., & Quintans-Júnior, L. J. (2025). Botany, Ethnomedicinal Uses, Biological Activities, Phytochemistry, and Technological Applications of Morinda citrifolia Plants. Molecules (Basel, Switzerland), 30(18). https://doi.org/10.3390/molecules30183831

Nascimento, L. C. S., da Rodrigues, N. R., Alves, M. P. C., Sabaa-Srur, A. U. O., Barbosa Júnior, J. L., & Barbosa, M. I. M. J. (2018). Chemical characterization, nutritional aspects and antioxidant capacity of noni (Morinda citrifolia L) produced in northeastern Brazil. International Food Research Journal.

Ni, Q., Zhang, Z., Niu, L., Yang, R., Xiong, L., Li, D., & Dai, Z. (2025). Research Progress on Nutritional Properties of Noni (Morinda citrifolia L.) Fruit and Its Fermented Foods. Fermentation, 11(7), 1–29. https://doi.org/10.3390/fermentation11070358

Noviana, R., Fajrina, A., Eriadi, A., & Asra, R. (2021). Antimicrobial Activity of Morinda citrifolia L. Asian Journal of Pharmaceutical Research and Development, 9(1), 141–148. https://doi.org/10.22270/ajprd.v9i1.924

Nugraha, A. S., Kintoko, K., Putri, C. P. Z. S., Az-Zahra, F., Firli, L. N., Rani, D. M., Purnomo, Y. D., Nguyen, P. T. V., Puspitasari, R. M., Hartati, T., Triatmoko, B., Pratama, A. N. W., Wahyuni, D. S. C., Muliasari, H., Keller, P. A., & Wangchuk, P. (2025). Antidiabetic medicinal plants of Indonesia: their in silico, in vitro, in vivo and clinical trial studies. In Phytochemistry Reviews (Vol. 0123456789). Springer Netherlands. https://doi.org/10.1007/s11101-025-10173-y

Oluwafemi Oyabambi, A., Boluwatife Aindero, B., Eunice Fashetan, B., & Tinuola Oni, K. (2023). Morinda Citrifolia (Noni) attenuated transcriptional and degenerative markers of cardiac toxicity in bisphenol A treated male wistar rats. Journal of Functional Foods, 110(October), 105865. https://doi.org/10.1016/j.jff.2023.105865

Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., Chou, R., Glanville, J., Grimshaw, J. M., Hróbjartsson, A., Lalu, M. M., Li, T., Loder, E. W., Mayo-Wilson, E., McDonald, S., … Moher, D. (2021). The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ, 372, n71. https://doi.org/10.1136/bmj.n71

Rae Galang Perdana, M., Budi Koendhori, E., & Hermanto, B. (2022). Antibacterial Activity of Noni Fruit Extract (Morinda citrifolia) against Staphylococcus aureus ATCC 25923 and Methicillin Resistant Staphylococcus aureus (MRSA). International Journal of Research Publications, 115(1). https://doi.org/10.47119/ijrp10011511220224277

Sabarrela, S., Ifora, I., & Fauziah, F. (2022). Phytochemical and Antidiabetic Activity of Morinda citrifolia: A Review. IOSR Journal Of Pharmacy And Biological Sciences (IOSR-JPBS) e-ISSN, 17(4), 32–38. https://doi.org/10.9790/3008-1704023238

Sabirin, I. P. R., & Yuslianti, E. R. (2016). Benefits of Ethanolic Extract Paste of Noni (Morinda citrifolia L.) Leaves on Oral Mucosa Wound Healing by Examination of Fibroblast Cells. Journal of Dentistry Indonesia, 23(3), 59–63. https://doi.org/10.14693/jdi.v23i3.980

Sudibyo, A., & Hutajulu, T. (2016). A Review on Recent Researches of Morinda Citrifolia, L. (Noni) as Functional Foods and Medical Herbs. Jurnal Riset Teknologi Industri, 10, 172. https://doi.org/10.26578/jrti.v10i2.2569

Tanikawa, T., Kitamura, M., Hayashi, Y., Tomida, N., Uwaya, A., Isami, F., Yokogawa, T., & Inoue, Y. (2023). Anti-inflammatory Effect of a Combination of Cannabidiol and Morinda citrifolia Extract on Lipopolysaccharide-stimulated RAW264 Macrophages. In Vivo, 37(2.0), 591–595. https://doi.org/10.21873/invivo.13117

Thiyagarajulu, N., Chinnaperumal, C., Paramasivam, P., Sonia Angeline, M. S., Akkara, P. J., Lakshminarayanan, L., Marunganathan, V., Alhegaili, A. S., & Ajay, A. (2025). Green synthesis of graphene oxide sheets via Morinda citrifolia leaf extract: a sustainable approach for multifunctional biomedical applications. 3 Biotech. https://doi.org/10.1007/s13205-025-04531-y

West, B. J., Deng, S., Isami, F., Uwaya, A., & Jensen, C. J. (2018). The Potential Health Benefits of Noni Juice: A Review of Human Intervention Studies. Foods (Basel, Switzerland), 7(4). https://doi.org/10.3390/foods7040058

Zhang, B., Wei, X., Du, P., Luo, H., Hu, L., Guan, L., & Chen, G. (2025). Structural Characterization of Polysaccharides from Noni (Morinda citrifolia L.) Juice and Their Preventive Effect on Oxidative Stress Activity. Molecules, 30(5.0). https://doi.org/10.3390/molecules30051103

Zhang, Q., Li, Y., Yin, G., Li, Y., Zhao, Y., Guo, X., Guo, Y., & Yan, S. (2022). The effects of supplementation of noni fruit polysaccharides-rich extract on antioxidant status and immune function in cashmere goats. Journal of Animal Science, 100(10.0). https://doi.org/10.1093/jas/skac276

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Published

2026-03-31

Issue

Vol. 7 No. 1 (2026): MARET 2026

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Articles

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Copyright (c) 2026 Rizki Amandani, Nikmah Nuur Rochmah, Yuhansyah Nur Fauzi

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