KORELASI LDL DAN MIKROALBUMINURIA PADA PASIEN DIABETES MELLITUS TIPE 2
DOI:
https://doi.org/10.31004/jkt.v6i4.53384Keywords:
Diabetes mellitus tipe 2, dislipidemia, ldl, mikroalbuminuria, penyakit ginjal kronisAbstract
Mikroalbuminuria merupakan penanda dini kerusakan ginjal diabetik pada pasien Diabetes Melitus (DM) tipe 2 dan berhubungan dengan peningkatan risiko penyakit ginjal kronis. Dislipidemia, terutama peningkatan kadar low density lipoprotein (LDL), diduga berperan dalam kerusakan glomerulus, namun bukti hubungan langsung LDL dengan mikroalbuminuria di layanan primer Indonesia masih terbatas. Penelitian ini bertujuan menilai korelasi antara kadar LDL dan mikroalbumin urin pada pasien DM tipe 2 peserta Program Pengelolaan Penyakit Kronis (Prolanis) di Puskesmas Kedaton. Desain penelitian menggunakan analitik observasional potong lintang pada 87 pasien yang memenuhi kriteria inklusi. Data LDL (mg/dL) dan mikroalbumin urin (mg/L) diperoleh dari rekam medis dan pemeriksaan laboratorium. Uji normalitas Kolmogorov–Smirnov menunjukkan distribusi normal pada LDL dan tidak normal pada mikroalbumin, sehingga analisis korelasi menggunakan uji Spearman. Hasil menunjukkan korelasi positif sangat lemah antara LDL dan mikroalbumin urin (r = 0,152; p = 0,160), sehingga tidak terdapat hubungan bermakna secara statistik. Temuan ini mengindikasikan bahwa kadar LDL total bukan prediktor utama mikroalbuminuria pada pasien DM tipe 2 di layanan primer. Faktor risiko lain, seperti kontrol glikemik, tekanan darah, dan durasi penyakit, tetap perlu menjadi fokus utama dalam pencegahan dan deteksi dini penyakit ginjal diabetik. Penelitian ini menekankan pentingnya pendekatan multifaktor untuk menurunkan risiko komplikasi ginjal pada pasien DM tipe 2 di setting primer.References
Ali, H. M. S. (2025). Dyslipidemia and Its Association with Microalbuminuria in Children and Adolescents with Type 1 Diabetes. The Egyptian Journal of Hospital Medicine, 100(July), 2656–2660.
American Diabetes Association. (2024). Chronic Kidney Disease and Risk Management : Standards of Care in Diabetes 2024. Diabetes Care, 47(January), 219–230. https://doi.org/10.2337/dc24-S011%0AAmerican
Bae, E. S., Hur, J. Y., Jang, H. S., Kim, J. S., & Kang, H. S. (2023). Risk Factors of Microalbuminuria among Patients with Type 2 Diabetes Mellitus in Korea : A Cross-Sectional Study Based on 2019 – 2020 Korea National Health and Nutrition Examination Survey Data. International Journal of Environmental Research and Public Health, 20, 1–11. https://doi.org/10.3390/ ijerph20054169
Boer, I. H. De, Khunti, K., Sadusky, T., Tuttle, K. R., Neumiller, J. J., Rhee, C. M., Rosas, S. E., Rossing, P., & Bakris, G. (2022). Diabetes Management in Chronic Kidney Disease: A Consensus Report by the American Diabetes Association (ADA) and Kidney Disease: Improving Global Outcomes (KDIGO). Kidney International, 102(5), 974–989. https://doi.org/10.1016/j.kint.2022.08.012
Ma, X., Ma, J., Leng, T., Yuan, Z., Hu, T., Liu, Q., & Shen, T. (2023). Advances in Oxidative Stress in Pathogenesis of Diabetic Kidney Disease and Efficacy of TCM Intervention. Renal Failure, 45(1). https://doi.org/10.1080/0886022X.2022.2146512
Pramesona, B. A., Kurniawan, B., Iqbal, M., Triyandi, R., Sesunan, D. S. A., Puspitasari, L., Budyantara, R., Sipahutar, E., & Nafia, I. (2025). Pencegahan Diabetes Mellitus Tipe 2 Pada Masyarakat Perkotaan dengan Promosi Kesehatan di Wilayah Kerja Puskesmas. JCOMENT (Journal of Community Empowerment), 6(3), 158–166. https://doi.org/10.55314/jcoment.v6i3.1034
Roumeliotis, S., Georgianos, P. I., Roumeliotis, A., Eleftheriadis, T., Stamous, A., Manolopoulos, V. G., Panagoutsos, S., & Liakopoulos, V. (2021). Oxidized LDL Modifies the Association between Proteinuria and Deterioration of Kidney Function in Proteinuric Diabetic Kidney Disease. Life 2021, 11(504), 1–11. https://doi.org/10.3390/ life11060504
Sauriasari, R., Zulfa, A. I., Sekar, A. P., Azmi, N. U., Tan, X. W., & Matsuura, E. (2022). Role of Urinary H2O2, 8-iso-PGF2a, and Serum oxLDL/β 2GP1 Complex in the Diabetic Kidney Disease. PLOS ONE, 1–14. https://doi.org/10.1371/journal.pone.0263113
Soegondo, S., Prodjosudjadi, W., & Setiawati, A. (2009). Prevalence and Risk Factors for Microalbuminuria in a Cross-Sectional Study of Type-2 Diabetic Patients in Indonesia : A Subset of DEMAND Study. Med J Indones, 18, 124–130.
Tsinari, A., Roumeliotis, S., Neofytou, I. E., Varouktsi, G., Veljkovic, A., Stamou, A., Leivaditis, K., & Liakopoulos, V. (2025). The Clinical Utility and Plausibility of Oxidative and Antioxidant Variables in Chronic and End-Stage Kidney Disease : A Review of the Literature. International Journal of Molecular Sciences, 26, 3376–3405. https://doi.org/https://doi.org/10.3390/ ijms26073376
Tu, Q. M., Jin, H. M., & Yang, X. H. (2025). Lipid Abnormality in Diabetic Kidney Disease and Potential Treatment Advancements. Frontiers in Endocrinology, March, 1–10. https://doi.org/10.3389/fendo.2025.1503711
Yani, A., Widhayanti, R. L., & Siswanto, B. (2023). The Prevalence of Microalbuminuria in Type 2 Diabetes Mellitus Patients in Ilanur Mother and Child Hospital Tangerang. Journal of Noncommunicable Diseases Prevention and Control, 1(1), 20–26. https://doi.org/https://doi.org/10.61843/jondpac.v1i1.501
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