POTENSI KURKUMIN SEBAGAI AGEN KONTRASEPSI HERBAL : ANALISIS LITERATUR MODEL HEWAN TIKUS BETINA
DOI:
https://doi.org/10.31004/jkt.v6i4.52159Keywords:
kontrasepsi herbal, kurkumin, literatur review, reproduksi, tikus betinaAbstract
Kurkumin merupakan senyawa aktif utama dari tanaman Curcuma longa yang memiliki berbagai aktivitas biologis, termasuk antioksidan, antiinflamasi, dan imunomodulator. Beberapa tahun terakhir, penelitian mulai mengeksplorasi potensi kurkumin sebagai agen kontrasepsi alami melalui pengaruhnya terhadap sistem reproduksi, khususnya pada model hewan tikus betina. Literatur review ini bertujuan untuk menganalisis hasil-hasil penelitian terbaru (2023–2025) yang mengevaluasi efek kurkumin terhadap reproduksi tikus betina. Menggunakan alur PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses), yang berbasis data utama pada ScienceDirect, PubMed, dan Springer untuk periode 2023–2025. Kata kunci yang digunakan meliputi: "curcumin" OR "contraceptive" OR "female rats" OR "reproductive toxicity curcumin" OR "ovarian histology curcumin". Dengan kriteria inkulusi penelitian eksperimental in vivo menggunakan tikus betina, dosis kurkumin, durasi perlakuan, mengukur minimal satu dari parameter kadar hormon reproduksi (FSH, LH, estrogen, progesteron)/jumlah atau perkembangan folikel ovarium/histologi ovarium/siklus estrus. Berdasarkan hasil tinjauan pustaka, kurkumin menunjukkan potensi menurunkan kadar hormon estrogen, FSH, dan LH, serta mengganggu maturasi folikel ovarium melalui mekanisme stres oksidatif. Data masih terbatas dan cenderung beragam tergantung dosis dan lama paparan. Dengan demikian, diperlukan penelitian lanjutan untuk memastikan keamanan dan efektivitas kurkumin sebagai kandidat kontrasepsi herbal.References
Alaee, S., Khodabandeh, Z., Dara, M., Hosseini, E., & Sharma, M. (2024). Curcumin mitigates acrylamide-induced ovarian antioxidant disruption and apoptosis in female Balb/c mice: A comprehensive study on gene and protein expressions. Food Science & Nutrition, 12(6), 4160–4172. https://doi.org/10.1002/fsn3.4076
Caesar, J., Widjiati, W., Herupradoto, E. B. A., Sukmanadi, M., Madyawati, S. P., Plumeriastuti, H., & Luqman, E. M. (2024). Effect of curcumin nanoparticles on the number of preantral and antral follicles of white rats (Rattus norvegicus) exposed to carbon black. Open Veterinary Journal, 14(12), 3309–3316. https://doi.org/10.5455/OVJ.2024.v14.i12.15
Chen, Y., et al. (2024). Curcumin disrupts estrous cycle through modulation of hormonal axis. Life Sciences, 345, 121123.
Fatimah, N., & Yulistia, R. (2018). Pengaruh kurkumin terhadap sekresi hormon progesteron pada kultur sel luteal tikus. Jurnal Kedokteran YARSI, 26(3), 156–164. https://academicjournal.yarsi.ac.id/index.php/jky/article/view/210
Fuloria, S., Mehta, J., Chandel, A., Sekar, M., Rani, N. N. I. M., Begum, M. Y., Subramaniyan, V., Chidambaram, K., Thangavelu, L., Nordin, R., Wu, Y. S., Sathasivam, K. V., Lum, P. T., Meenakshi, D. U., Kumarasamy, V., Azad, A. K., & Fuloria, N. K. (2022). A comprehensive review on the therapeutic potential of Curcuma longa Linn. in relation to its major active constituent curcumin. Frontiers in Pharmacology, 13, 820806. https://doi.org/10.3389/fphar.2022.820806
Hasanah, R., et al. (2025). The impact of curcumin on follicular development in female Wistar rats. Pharmacognosy Research, 17(2), 98–106.
Hendarto, H., Hutama, S. A., Primariawan, R. Y., Alkaff, F. F., Utomo, B. S., Widjiati, W., & Suzuki, N. (2025). Nano-curcumin potentially ameliorates hormonal function and follicular counts following the vitrification and transplantation of rat ovarian tissue. Scientific Reports, 15, 34588. https://doi.org/10.1038/s41598-025-34588-5
Kamal, D. A. M., Hassandarvish, P., & Tiong, S. K. (2021). Potential health benefits of curcumin on female reproductive disorders: A review. Nutrients, 13(9), 3126. https://doi.org/10.3390/nu13093126
Kececi, M., & Karaoluk, N. (2025). Effect of curcumin on methotrexate-induced ovarian damage and follicle reserve in rats: The role of PARP-1 and P53. Annals of Medicine, 57(1), 2446688. https://doi.org/10.1080/07853890.2024.2446688
Lin, X., et al. (2025). Endocrine disrupting potential of curcumin in female rats. Toxicology Reports, 12, 552–560.
Lv, Y., Cao, R.-C., Liu, H.-B., & Xia, X. (2021). Single-oocyte gene expression suggests that curcumin can protect the ovarian reserve by regulating the PTEN-AKT-FOXO3a pathway. International Journal of Molecular Sciences, 22(12), 6570. https://doi.org/10.3390/ijms22126570
Maiti, R. N., Roy, U. K., Das, S., & Das, A. K. (2021). Antifertility effect of curcumin, an indigenous medicine in rats. International Journal of Basic & Clinical Pharmacology, 10(2), 167–171. https://doi.org/10.18203/2319-2003.ijbcp20210185
Melekoglu, R., Ciftci, O., Eraslan, S., et al. (2018). Beneficial effects of curcumin and capsaicin on cyclophosphamide-induced premature ovarian failure in a rat model. Journal of Ovarian Research, 11, 33. https://doi.org/10.1186/s13048-018-0409-9
Mongy, S., Abdel-Hakeem, M. A., & Omar, A. R. (2024). Curcumin-loaded chitosan-protamine nanoparticles: A promising approach to ameliorate nicotine-induced reproductive disorders in male rats. Journal of Drug Delivery Science and Technology, 91, 105159.
Qiao, X., Ye, L., Lu, J., Pan, C., Fei, Q., & Zhu, Y. (2023). Curcumin analogues exert potent inhibition on human and rat gonadal 3β-hydroxysteroid dehydrogenases as potential therapeutic agents: Structure–activity relationship and in silico docking. Journal of Enzyme Inhibition and Medicinal Chemistry, 38(1), Article 2205052. https://doi.org/10.1080/14756366.2023.2205052
Rai, G., Namdev, N., & Mahobiya, P. (2020). Ascorbic acid and curcumin alleviate abnormal estrous cycle and morphological changes in cells induced by repeated ultraviolet B radiations in female Wistar rats. Asian Pacific Journal of Reproduction, 9(3), 142–147. https://doi.org/10.4103/2305-0500.284276
Rahman, F., et al. (2023). Effects of curcumin on reproductive hormones in female rats. Journal of Ethnopharmacology, 312, 116567.
Sari, D., & Lestari, A. (2024). Histological alterations of ovarian tissue induced by curcumin in rats. Reproductive Biology, 42(1), 77–84.
Shokoohi, M., Shoorei, H., Khaki, A. A., Karimi, M., Asemi, Z., Heidari-Soureshjani, R., & Bahmani, M. (2022). Therapeutic effect and safety of curcumin in women with PCOS: A systematic review and meta-analysis. Frontiers in Endocrinology, 13, 1051111. https://doi.org/10.3389/fendo.2022.1051111
Sirotkin, A. V. (2022). The influence of turmeric and curcumin on female reproductive processes. Planta Medica, 88(12), 1020–1025. https://doi.org/10.1055/a-1542-8992
Zhang, W., Peng, C., Xu, L., Zhao, Y., Huang, C., & Lu, L. (2024). The therapeutic effects of curcumin on polycystic ovary syndrome by upregulating PPAR-γ expression and reducing oxidative stress in a rat model. Frontiers in Endocrinology, 15, 1494852. https://doi.org/10.3389/fendo.2024.1494852
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