FAKTOR RISIKO YANG BERHUBUNGAN DENGAN TERJADINYA GLAUKOMA : TINJAUAN LITERATUR

Authors

  • Aulia Putri Mussyafa S1 Kedokteran, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Mataram

DOI:

https://doi.org/10.31004/jkt.v6i4.50663

Keywords:

Diabetes Melitus, Glaukoma, Hipertensi, Kebutaan, Tekanan Intraokular

Abstract

Glaukoma menjadi salah satu penyakit mata neurodegeneratif progresif yang dapat menyebabkan kebutaan. Secara global, glaukoma menempati urutan kedua penyebab kebutaan dan urutan keempat penyebab moderate and severe visual impairment. Glaukoma pada fase awal umumnya tidak menunjukkan gejala yang dapat disadari oleh penderitanya sampai terjadi kerusakan saraf optik yang lebih lanjut. Glaukoma bersifat multifaktorial dan memiliki patofisiologi yang kompleks. Sehingga diperlukan deteksi dini untuk menangani risiko lebih besar kehilangan penglihatan secara permanen dengan mengetahui faktor-faktor yang meningkatkan risiko terkena glaukoma. Penelitian ini merupakan tinjauan pustaka dengan desain deskriptif, yang mana pencarian dan peninjauan berbagai sumber kepustakaan dari database online seperti Pubmed, Google Scholar, dan ResearchGate. Pencarian literatur menggunakan beberapa kombinasi kata dan menyaring hasilnya berdasarkan kriteria inkulusi dan eksklusi. Hasil  yang diperoleh adalah glaukoma memiliki beberapa faktor risiko seperti usia lanjut >40 tahun, laki-laki dan perempuan memiliki risiko sama dengan tipe glaukoma yang berbeda, tekanan darah sistolik yang tinggi, riwayat diabetes melitus dan durasi diabetes melitus. Berdasarkan beberapa  penelitian, faktor-faktor risiko tersebut memiliki mekanisme tersendiri yang dapat meningkatkan risiko terkena glaukoma. Salah satunya yaitu dapat meningkatkan tekanan intraokular dan penipisan retinal nerve fiber layer yang lebih awal. Tekanan intraokular yang meningkat dapat merusak saraf optik dan menyebabkan kehilangan penglihatan secara permanen.

References

Ahram, D. F., Alward, W. L., & Kuehn, M. H. (2015). The genetic mechanisms of primary angle closure glaucoma. Eye (Basingstoke), 29(10), 1251–1259. https://doi.org/10.1038/eye.2015.124

Asrani, S. G., McGlumphy, E. J., Al-Aswad, L. A., Chaya, C. J., Lin, S., Musch, D. C., Pitha, I., Robin, A. L., Wirostko, B., & Johnson, T. V. (2024). The relationship between intraocular pressure and glaucoma: An evolving concept. In Progress in Retinal and Eye Research (Vol. 103). Elsevier Ltd. https://doi.org/10.1016/j.preteyeres.2024.101303

Baek, S. U., Kee, C., & Suh, W. (2015). Longitudinal analysis of age-related changes in intraocular pressure in South Korea. Eye (Basingstoke), 29(5), 625–629. https://doi.org/10.1038/eye.2015.11

Baudouin, C., Kolko, M., Melik-Parsadaniantz, S., & Messmer, E. M. (2021). Inflammation in Glaucoma: From the back to the front of the eye, and beyond. In Progress in Retinal and Eye Research (Vol. 83). Elsevier Ltd. https://doi.org/10.1016/j.preteyeres.2020.100916

Bourne, R. R. A., Taylor, H. R., Flaxman, S. R., Keeffe, J., Leasher, J., Naidoo, K., Pesudovs, K., White, R. A., Wong, T. Y., Resnikoff, S., & Jonas, J. B. (2016). Number of people blind or visually impaired by glaucoma worldwide and in world regions 1990 - 2010: A meta-analysis. PLoS ONE, 11(10). https://doi.org/10.1371/journal.pone.0162229

Chen, H., Lin, H., Lin, Z., Chen, J., & Chen, W. (2016). Distribution of axial length, anterior chamber depth, and corneal curvature in an aged population in South China. BMC Ophthalmology, 16(1). https://doi.org/10.1186/s12886-016-0221-5

Dizayang, F., Bambang, H., & Purwoko, M. (2020). Karakteristik Penderita Glaukoma di Rumah Sakit Muhammadiyah Palembang Periode Januari 2017-April 2018. Journal of Health Sciences, 13(01), 66–73. https://doi.org/10.33086/jhs.v13i01.1146

Flaxman, S. R., Bourne, R. R. A., Resnikoff, S., Ackland, P., Braithwaite, T., Cicinelli, M. V., Das, A., Jonas, J. B., Keeffe, J., Kempen, J., Leasher, J., Limburg, H., Naidoo, K., Pesudovs, K., Silvester, A., Stevens, G. A., Tahhan, N., Wong, T., Taylor, H., … Zheng, Y. (2017). Global causes of blindness and distance vision impairment 1990–2020: a systematic review and meta-analysis. The Lancet Global Health, 5(12), e1221–e1234. https://doi.org/10.1016/S2214-109X(17)30393-5

Ghanbarnia, M. J., Panahi, N. M., Rasoulinejad, S. A., Hosseini, S. R., Shirafkan, H., Roustaei, G. A., Mekaniki, E., Ghasemi, M., Ghadimi, R., & Bijani, A. (2023). Age-specific distribution of intraocular pressure in elderly Iranian population and its associated factors. Caspian Journal of Internal Medicine, 14(1), 112–120. https://doi.org/10.22088/cjim.14.1.112

Harasymowycz, P., Birt, C., Gooi, P., Heckler, L., Hutnik, C., Jinapriya, D., Shuba, L., Yan, D., & Day, R. (2016). Medical Management of Glaucoma in the 21st Century from a Canadian Perspective. In Journal of Ophthalmology (Vol. 2016). Hindawi Publishing Corporation. https://doi.org/10.1155/2016/6509809

Hasan, R., Ashan, H., Yuli Amelia, A., & Triola, S. (2022). Profil Pasien Glaukoma pada Lansia di Rumah Sakit Khusus Mata (RSKM) Padang Eye Center Tahun 2021. Scientific Journal , 1(5), 356–364. http://journal.scientic.id/index.php/sciena/issue/view/5

Iyer, J. V., Boland, M. V., Jefferys, J., & Quigley, H. (2021). Defining glaucomatous optic neuropathy using objective criteria from structural and functional testing. British Journal of Ophthalmology, 105(6), 789–793. https://doi.org/10.1136/bjophthalmol-2020-316237

Mahendra, B. I., Gustianty, E., & Rifada, R. M. (2022). KARAKTERISTIK KLINIS GLAUKOMA PRIMER SUDUT TERTUTUP DI PUSAT MATA NASIONAL RUMAH SAKIT MATA CICENDO PADA TAHUN 2020. Jurnal Kedokteran Dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya, 9(2), 235–244. https://doi.org/10.32539/jkk.v9i2.16963

Michels, T. C., & Ivan, O. (2023). Glaucoma: Diagnosis and Management. American Family Physician, 107(3), 253–262.

Nislawati, R., Taufik Fadillah Zainal, A., Ismail, A., Waspodo, N., Kasim, F., & Gunawan, A. M. A. K. (2021). Role of hypertension as a risk factor for open-angle glaucoma: A systematic review and meta-analysis. In BMJ Open Ophthalmology (Vol. 6, Issue 1). BMJ Publishing Group. https://doi.org/10.1136/bmjophth-2021-000798

Nurmalasari, Y., & Hermawan, R. M. (2017). KARAKTERISTIK PASIEN GLAUKOMA BERDASARKAN FAKTOR INSTRINSTIK DI RUMAH SAKIT PERTAMINA BINTANG AMIN BANDAR LAMPUNG. Jurnal Ilmu Kedokteran Dan Kesehatan, 4(2), 85–90.

Peng, P. H., Hsu, S. Y., Wang, W. S., & Ko, M. L. (2017). Age and axial length on peripapillary retinal nerve fiber layer thickness measured by optical coherence tomography in nonglaucomatous Taiwanese participants. PLoS ONE, 12(6). https://doi.org/10.1371/journal.pone.0179320

Phu, J., Tong, J., Zangerl, B., Le, J. L., & Kalloniatis, M. (2020). Cluster analysis reveals patterns of age-related change in anterior chamber depth for gender and ethnicity: clinical implications. Ophthalmic and Physiological Optics, 40(5), 632–649. https://doi.org/10.1111/opo.12714

Plotnikov, D., Huang, Y., Khawaja, A. P., Foster, P. J., Zhu, Z., Guggenheim, J. A., & He, M. (2022). High Blood Pressure and Intraocular Pressure: A Mendelian Randomization Study. Investigative Ophthalmology and Visual Science, 63(6). https://doi.org/10.1167/iovs.63.6.29

Schuster, A. K., Erb, C., Hoffmann, E. M., Dietlein, T., & Pfeiffer, N. (2020). The diagnosis and treatment of glaucoma. Deutsches Arzteblatt International, 117(13), 225–234. https://doi.org/10.3238/arztebl.2020.0225

Shanty, N. M. A., Triningrat, A. A. M. P., Sutyawan, I. W. E., & Kusumadjaja, I. M. A. (2023). GAMBARAN GLAUKOMA PRIMER SUDUT TERBUKA PADA PASIEN DI POLIKLINIK MATA RUMAH SAKIT UMUM PUSAT (RSUP) SANGLAH DENPASAR PERIODE JANUARI 2020-DESEMBER 2020. Jurnal Medika Udayana, 12(4), 1. https://doi.org/10.24843.MU.2023.V12.i4.P01

Sihota, R., Angmo, D., Ramaswamy, D., & Dada, T. (2018). Simplifying “target” intraocular pressure for different stages of primary open-angle glaucoma and primary angle-closure glaucoma. In Indian Journal of Ophthalmology (Vol. 66, Issue 4, pp. 495–505). Medknow Publications. https://doi.org/10.4103/ijo.IJO_1130_17

Sun, X., Dai, Y., Chen, Y., Yu, D. Y., Cringle, S. J., Chen, J., Kong, X., Wang, X., & Jiang, C. (2017). Primary angle closure glaucoma: What we know and what we don’t know. In Progress in Retinal and Eye Research (Vol. 57, pp. 26–45). Elsevier Ltd. https://doi.org/10.1016/j.preteyeres.2016.12.003

Takis, A., Alonistiotis, D., Ioannou, N., Kontou, E., Mitsopoulou, M., & Papaconstantinou, D. (2017). Follow-up of the retinal nerve fiber layer thickness of diabetic patients type 2, as a predisposing factor for glaucoma compared to normal subjects. Clinical Ophthalmology, Volume 11, 1135–1141. https://doi.org/10.2147/OPTH.S129935

Zhang, N., Wang, J., Chen, B., Li, Y., & Jiang, B. (2021). Prevalence of Primary Angle Closure Glaucoma in the Last 20 Years: A Meta-Analysis and Systematic Review. In Frontiers in Medicine (Vol. 7). Frontiers Media S.A. https://doi.org/10.3389/fmed.2020.624179

Zhang, N., Wang, J., Li, Y., & Jiang, B. (2021). Prevalence of primary open angle glaucoma in the last 20 years: a meta-analysis and systematic review. Scientific Reports, 11(1). https://doi.org/10.1038/s41598-021-92971-w

Zhao, D., Cho, J., Kim, M. H., Friedman, D. S., & Guallar, E. (2015). Diabetes, fasting glucose, and the risk of glaucoma: A meta-analysis. In Ophthalmology (Vol. 122, Issue 1, pp. 72–78). Elsevier Inc. https://doi.org/10.1016/j.ophtha.2014.07.051

Zhao, Y. X., & Chen, X. W. (2017). Diabetes and risk of glaucoma: Systematic review and a meta-analysis of prospective cohort studies. In International Journal of Ophthalmology (Vol. 10, Issue 9, pp. 1430–1435). International Journal of Ophthalmology (c/o Editorial Office). https://doi.org/10.18240/ijo.2017.09.16

Downloads

Published

2025-12-28