A COMPREHENSIVE REVIEW OF THE CORRELATION BETWEEN VITAMIN D LEVELS AND MULTIORGAN FUNCTION IN OBESE CHILDREN

Authors

  • Vebry Alisa Departement of Emergency, Hospital Permata Bunda Ketapang, West Kalimantan, Indonesia
  • Widarti Pujiasih Haryanto Primary Health Care Unit, Puskesmas Kundi, West Bangka Regency, Bangka Belitung Island, Indonesia
  • Hedya Nadhrati Surura Departement of Psychiatry, Universitas Syiah Kuala, Aceh, Indonesia

DOI:

https://doi.org/10.31004/jkt.v6i3.49647

Keywords:

Vitamin D, 1,25(OH)₂D₃, Calcitriol, Obesity, Child, Children, Childhood

Abstract

Obesitas pada anak-anak merupakan masalah kesehatan global yang semakin umum, terkait dengan komplikasi metabolik, kardiovaskular, dan inflamasi. Vitamin D memainkan peran penting dalam metabolisme glukosa dan lipid serta memiliki efek anti-inflamasi; namun, perannya pada anak-anak obesitas masih kurang dieksplorasi. Tujuan studi ini adalah untuk menganalisis hubungan antara status vitamin D dan hasil metabolik pada anak-anak obesitas berdasarkan uji klinis terkontrol acak (RCT). Ulasan literatur dilakukan menggunakan basis data PubMed, ScienceDirect, dan Cochrane Library untuk RCT yang diterbitkan antara tahun 2021 dan 2025. Kata kunci yang digunakan meliputi “Vitamin D,” “1,25(OH)₂D₃,” “Calcitriol,” “Obesitas,” “Anak,” “Anak-anak,” dan “Kehidupan Anak-anak.” Studi yang memenuhi syarat adalah artikel teks lengkap berbahasa Inggris dengan desain RCT. Hasil studi ini melaporkan bahwa tujuh RCT dimasukkan. Anak-anak obesitas secara konsisten menunjukkan kadar vitamin D yang lebih rendah dibandingkan dengan anak-anak dengan berat badan normal. Kekurangan vitamin D dikaitkan dengan resistensi insulin melalui gangguan sinyal reseptor vitamin D (VDR), serta dislipidemia dan peningkatan penanda inflamasi. Suplementasi vitamin D dosis tinggi (≥ 2000 IU/hari atau dosis awal 50.000 IU) terbukti secara signifikan meningkatkan kadar serum 25(OH)D menjadi ≥ 40 ng/mL, memperbaiki profil lipid, dan mengurangi peradangan sistemik. Kesimpulan: Defisiensi vitamin D pada anak obesitas memperburuk disfungsi metabolik melalui resistensi insulin, kelainan lipid, dan peradangan kronis.

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Published

2025-09-29

Issue

Vol. 6 No. 3 (2025): SEPTEMBER 2025

Section

Articles

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Copyright (c) 2025 Vebry Alisa, Widarti Pujiasih Haryanto, Hedya Nadhrati Surura

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