FORMULASI SEDIAAN GEL MOISTURIZER EKSTRAK DAUN KIRINYUH (Chromolaena odorata) DENGAN UJI ANTIOKSIDAN, UJI MUTU FISIK DAN UJI STABILITAS FISIK
DOI:
https://doi.org/10.31004/jkt.v6i3.49009Keywords:
antioksidan, chromolaena odorata l., DPPH, gel moisturizer, stabilitasAbstract
Pendahuluan: Antioksidan berperan penting dalam menangkal radikal bebas penyebab stres oksidatif yang dapat merusak sel kulit. Daun kirinyuh (Chromolaena odorata L.) diketahui mengandung senyawa flavonoid, tanin, dan fenol yang memiliki potensi sebagai antioksidan alami. Penelitian ini bertujuan untuk memformulasikan gel moisturizer berbahan ekstrak etanol daun kirinyuh serta mengevaluasi mutu fisik, stabilitas, dan aktivitas antioksidannya. Metode: Gel diformulasikan dengan variasi konsentrasi Carbopol, dan dilakukan uji mutu fisik (organoleptik, pH, viskositas, daya sebar, dan daya lekat), stabilitas suhu ekstrem selama 3 siklus, serta uji aktivitas antioksidan menggunakan metode DPPH. Hasil: Penelitian menunjukkan bahwa formulasi F2 (Carbopol 1%) merupakan formula terbaik dengan mutu fisik stabil, pH 5,67–5,92, dan viskositas dalam rentang ideal. Uji antioksidan menunjukkan ekstrak daun kirinyuh memiliki nilai IC₅₀ sebesar 44,27 ppm, sedangkan sediaan gel moisturizer F2 sebesar 90,28 ppm, yang termasuk kategori aktivitas antioksidan kuat. Nilai ini lebih baik dibandingkan kontrol negatif dan mendekati kontrol positif (moisturizer vitamin C). Kesimpulan: Dengan demikian Carbopol 1% merupakan formulasi gel terbaik, dan ekstrak daun kirinyuh memiliki sifat antioksidan yang sangat kuat, bahkan setelah diformulasikan mendapatkan hasil antioksidan yang kuatReferences
Aiyalu, R., Govindarjan, A., & Ramasamy, A. (2016). Formulation and evaluation of topical herbal gel for the treatment of arthritis in animal model. Brazilian Journal of Pharmaceutical Sciences, 52(3), 493–507. https://doi.org/10.1590/s1984-82502016000300015
Al-Suwayeh, S. A., Taha, E. I., Al-Qahtani, F. M., Ahmed, M. O., & Badran, M. M. (2014). Evaluation of skin permeation and analgesic activity effects of carbopol lornoxicam topical gels containing penetration enhancer. Scientific World Journal, 2014. https://doi.org/10.1155/2014/127495
Amelia, N. A., & Noval. (2021). The Effect of Variations in Carbopol 940 Concentration on the Stability of the Formulation of Spray Gel Nanoparticles of Bundung Plant Extract (Actinoscirpus grossus). International Conference on Health Science, 1(10), 573–584. https://ocs.unism.ac.id/index.php/ICoHS/article/view/500
Atmaja, H. I. P., Fajaryanti, N., Mediastini, E., & Purnomo, D. P. (2022). Perbandingan Konsentrasi Carbopol terhadap Stabilitas Fisik Sediaan Gel Ekstrak Etanol Kulit Buah Alpukat. Jurnal Farmasetis; LPPM Sekolah Tinggi Ilmu Kesehatan Kendal, 11(2), 125–134.
Bajena, A. (2015). Normality Tests in Spss. 1–9.
Daud, N. S., Insani, A. A., Nurhikma, E., & Daud, N. S. (2021). Formulasi Dan Evaluasi Sediaan Masker Gel Peel-Off Ekstrak Bayam Merah (Amaranthus tricolor L.). Jurnal Farmasi Sains Dan Praktis, 7(3), 2579–4558. http://journal.ummgl.ac.id/index.php/pharmacy
Dodson, J. R., Avellar, T., Athayde, J., & Mota, C. J. A. (2018). Glycerol acetals with antioxidant properties. Pure and Applied Chemistry, 86(6), 905–911. https://doi.org/10.1515/pac-2013-1106
Grange, L. K., Kouchouk, A., Dalal, M. D., Vitale, S., Nussenblatt, R. B., Chan, C. C., & Sen, H. N. (2014). Neoplastic masquerade syndromes in patients with uveitis. American Journal of Ophthalmology, 157(3), 526–531. https://doi.org/10.1016/j.ajo.2013.11.002
Hafid, M., Setiawati, H., Pratiwi, I., Laspin, S., & Audia, D. (2020). Formulasi dan Uji Stabilitas Fisik Gel Ekstrak Etil Asetat Daun Sirih Hijau (Piper betle L) Menggunakan Variasi Basis Gel. Journal Pharmacy and Sciences ISSN, 11(2), 2723–0791. https://journal.unpacti.ac.id/FITO/article/view/113
Handayany, G. N., Umar, I., & Ismail, I. (2018). Formulasi Dan Uji Efektivitas Antioksidan Krim Ekstrak Etanol Daun Botto’-Botto’ (Chromolaena odorata L.) dengan METODE DPPH. Jurnal Kesehatan, 11(2), 86. https://doi.org/10.24252/kesehatan.v11i2.5944
Hasibuan, A. S., Edrianto, V., & Purba, N. (2020). Skrining Fitokimia Ekstrak Etanol Umbi Bawang Merah (Allium cepa L.). Jurnal Farmasimed (Jfm), 2(2), 45–49. https://doi.org/10.35451/jfm.v2i2.357
Hidayah, L. A., & Anggarani, M. A. (2022). Determination of Total Phenolic, Total Flavonoid, and Antioxidant Activity of India Onion Extract. In Indonesian Journal of Chemical Science (Vol. 11, Issue 2, pp. 123–135). https://doi.org/10.15294/ijcs.v11i2.54610
Ikhlas, N. (2020). Uji Aktivitas Antioksidan Ekstrak Herba Kemangi ( Ocimum americanum Linn) dengan Metode DPPH (2,2-Difenil-1-Pikrilhidrazil).
Ilham La Tansa, Bangkit Riska Permata, & Kusumaningtyas Siwi Artini. (2023). Formulasi Dan Uji Mutu Fisik Sediaan Bedak Padat Ekstrak Biji Bunga Matahari (Halianthus Annuus L.) Sebagai Antioksidan. Detector: Jurnal Inovasi Riset Ilmu Kesehatan, 1(4), 167–181. https://doi.org/10.55606/detector.v1i4.2517
Jamilah, S., Prihandini, Y. A., & Wahyunita, S. (2024). Uji Aktivitas Ekstrak Metanol Daun Kirinyuh (Chromolaena Ododrata L.) Terhadap Bakteri Staphylococcus Epidermidis. Malahayati Nursing Journal, 6(2), 677–688. https://doi.org/10.33024/mnj.v6i2.11623
Kemenkes RI. (2017). Farmakope Herbal Indonesia Edisi II. Pills and the Public Purse, 97–103. https://doi.org/10.2307/jj.2430657.12
Listiani, P. A. R., & Indraswari, P. I. I. (2021). Formulation, Physical Evaluation, and Antifungal Activity Determination ofTransparent Soap Containing 96% Ethanol Extract of Siam Weed(Chromolaena odorata (L.) R.M.King & H.Rob.) Leaves. Pharmaceutical Journal of Indonesia, 18(02), 324–333.
Lubrizol. (2018). Excipients for Liquid and Semisolid Dosage Forms Oral and Topical Applications. 1–7.
Maulida, P. A., Putri, D. A., & Fatmawati, S. (2019). Free Radical Scavenging Activity of Chromolaena odorata L. Leaves. IPTEK The Journal for Technology and Science, 30(3), 73. https://doi.org/10.12962/j20882033.v30i3.5409
Okzelia, S. D. (2022). Formulasi dan Evaluasi Gel dari Ekstrak Kulit Putih Semangka (Citrullus Lanatus [Thunb.] Matsum. & Nakai) sebagai Pelembap Kulit. Jurnal Sabdariffarma, 9(2), 33–44. https://doi.org/10.53675/jsfar.v3i2.394
Oriana, E., & Sawiji, R. T. (2024). Formulasi dan Uji Aktivitas Sediaan Gel Anti Jerawat Ekstrak Etanol Bunga Telang ( Clitoria ternatea L ) Formulation and Activity Evaluation of Anti-Acne Gel Containing Ethanol Extract of PHARMACY : Jurnal Farmasi Indonesia. 21(01), 20–25.
Pintea, A., Vlad, R. A., Antonoaea, P., Rédai, E. M., Todoran, N., Barabás, E. C., & Ciurba, A. (2022). The Ph Influence On The Carbopol Solutions Stabilization By Addition Of Naoh. Polymers, 14(22). https://doi.org/10.3390/polym14225011
Rahmi, S., & Susanti, D. (2023). The Effectiveness Of Drying Temperature And Time On Antioxidant And Sensory Activity Of Herbal Tea Kirinyuh Leaves (Chromolaen Odorata L.). Jurnal Teknologi Dan Industri Pertanian Indonesia, 15(2), 65–70. https://doi.org/10.17969/jtipi.v15i2.29404
Rosi, D. H., Efmisa, A. K., Fernandi, R., Armal, K., & Deswati. (2024). Formulasi Sediaan Gel Moisturizer Ekstrak Etanol Daun Bayam Merah (Amarantus tricolor L). Jurnal Medical Helath Science (JMHS), 1(1), 1–6.
Safitri, F. I., Nawangsari, D., & Febrina, D. (2021). Overview: Application of Carbopol 940 in Gel. 34(Ahms 2020), 80–84. https://doi.org/10.2991/ahsr.k.210127.018
Salkind, N. (2012). Honestly Significant Difference (HSD) Test. Encyclopedia of Research Design, 1–5. https://doi.org/10.4135/9781412961288.n181
Sawitri, S. B., Anggun Mahirotun Nur Sholikhah, Alya, & Rahmawati’, J. D. (2024). Jurnal Ilmiah Global Farmasi The Effect Of Carbopol Concentration Variation On The Stability Facial Wash Gel Preparation From Methanol Extract Of Rosela Flowers ( Hibiscus sabdariffa L .). 2(3), 21–33.
Shalsadila, R., & Nuryanti, M. (2023). Potential of Various Natural Materials as Natural Insecticides for Head Lice (Pediculus humanus capitis). Journal of Pharmaceutical and Sciences, 6(2), 664–672. https://www.journal-jps.com
Thomas, N. A., Suryadi, A. M. A., Latif, M. S., Hutuba, A. H., & Susanti, S. (2024). Formulasi dan Uji Stabilitas Fisik Krim Pelembab Ekstrak Rumput Laut (Eucheuma cottonii). Indonesian Journal of Pharmaceutical Education (e-Journal), 4(1), 2775–3670. https://doi.org/10.37311/ijpe.v4i1.20522
Thomas, N. A., Tungadi, R., Hiola, F., & S. Latif, M. (2023). Pengaruh Konsentrasi Carbopol 940 Sebagai Gelling Agent Terhadap Stabilitas Fisik Sediaan Gel Lidah Buaya (Aloe Vera). Indonesian Journal of Pharmaceutical Education, 3(2), 316–324. https://doi.org/10.37311/ijpe.v3i2.18050
Wulandari, L., & Umam, K. (2023). Potensi Ekstrak Daun Kirinyuh (Chromolaena odorata) dalam Menghambat Bakteri Patogen (E. sakazakii, S. typi, dan L. monocytogenes). Jurnal Ilmiah Biosaintropis (Bioscience-Tropic), 8(2), 18–31. https://doi.org/10.33474/e-jbst.v8i2.497
Yenti, R., Afrianti, R., & Endang P, A. (2016). Formulasi Krim Ekstrak Etanol Daun Kirinyuh (Eupatorium Odoratum L.) Sebagai Antiinflamasi. Scientia : Jurnal Farmasi Dan Kesehatan, 4(1), 7. https://doi.org/10.36434/scientia.v4i1.72
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