HUBUNGAN JUMLAH TROMBOSIT DENGAN KADAR TROPONIN I PADA PASIEN PENYAKIT JANTUNG KORONER DI RS PKU MUHAMMADIYAH GAMPING
DOI:
https://doi.org/10.31004/jkt.v6i3.48348Keywords:
jumlah trombosit, kerusakan miokard, sindrom koroner akut, troponin IAbstract
Penyakit jantung koroner (PJK) merupakan penyebab utama kematian global dan masalah ini tetap menjadi tantangan utama dalam sektor kesehatan di Indonesia. Salah satu mekanisme utama dalam PJK, khususnya Acute Coronary Syndrome (ACS), adalah kerusakan miokard yang ditandai dengan peningkatan troponin I, serta aktivasi trombosit yang berkontribusi terhadap proses iskemik. Tujuan dari penelitian ini adalah untuk mengetahui hubungan antara jumlah trombosit dan kadar troponin I pada pasien ACS. Studi ini menggunakan desain observasional analitik yang menggunakan pendekatan potong lintang (cross sectional) yang dilaksanakan di RS PKU Muhammadiyah Gamping. Pengambilan sampel dilakukan secara purposif terhadap 30 pasien dewasa yang terdiagnosis ACS dan memiliki data laboratorium lengkap. Data diperoleh dari rekam medis. Berdasarkan uji Shapiro-Wilk, data tidak berdistribusi secara normal, sehingga analisis hubungan antarvariabel dilakukan dengan uji korelasi Spearman menggunakan SPSS versi 27. Hasil menunjukkan bahwa rata-rata jumlah trombosit sebesar 280.870 x103/µL (SD 30.410) dan median kadar troponin I sebesar 203,300 ng/L (rentang 146,7-344,0). Terdapat hubungan positif yang kuat dan signifikan secara statistik antara jumlah trombosit dan kadar troponin I (r = 0,622; p = 0,000). Terdapat korelasi positif yang signifikan antara jumlah trombosit dan kadar troponin I pada pasien ACS. Pemeriksaan trombosit berpotensi digunakan sebagai indikator tambahan dalam menilai keparahan kerusakan miokard.)References
Benjamin, E. J., Muntner, P., Alonso, A., Bittencourt, M. S., Callaway, C. W., Carson, A. P., Chamberlain, A. M., Chang, A. R., Cheng, S., Das, S. R., Delling, F. N., Djousse, L., Elkind, M. S. V., Ferguson, J. F., Fornage, M., Jordan, L. C., Khan, S. S., Kissela, B. M., Knutson, K. L., … Virani, S. S. (2019). Heart Disease and Stroke Statistics-2019 Update: A Report From the American Heart Association. In Circulation (Vol. 139, Issue 10). https://doi.org/10.1161/CIR.0000000000000659
Celik, T., Balta, S., Ozturk, C., Unlu, M., & Iyisoy, A. (2016). Platelet Indices in Patients with Acute Coronary Syndromes. Angiology, 67(7), 697–698. https://doi.org/10.1177/0003319716638796
Chernukha, I. M., Kovalev, L. I., Mashentseva, N. G., Kovaleva, M. A., & Vostrikova, N. L. (2019). Detection of protein aggregation markers in raw meat and finished products. Foods and Raw Materials, 7(1), 118–123. https://doi.org/10.21603/2308-4057-2019-1-118-123
Husni, M., Buchari, L., & Boga, H. (2018). Hubungan Dislipidemia dan Diabetes Mellitus dengan Kejadian Penyakit Jantung Koroner Di RSUD Ulin Banjarmasin. Caring Nursing Journal, 2(2), 66–69. https://journal.umbjm.ac.id/index.php/caring-nursing/article/view/223
Karyatin, K. (2019). Faktor-Faktor Yang Berhubungan Dengan Kejadian Penyakit Jantung Koroner. Jurnal Ilmiah Kesehatan, 11(1), 37–43. https://doi.org/10.37012/jik.v11i1.66
Mohanty, N. K., Satpathy, C., Routray, S., & Dash, B. (2022). Correlation of platelet indices with the spectrum of acute coronary syndrome and extent of coronary artery disease. Panacea Journal of Medical Sciences, 12(1), 164–171. https://doi.org/10.18231/j.pjms.2022.031
Mustafic, S., Ibralic, A. M., & Loncar, D. (2022). Association of Inflammatory and Hemostatic Parameters With Values of High Sensitive Troponin in Patients With Acute Coronary Syndrome. Medical Archives, 76(2), 84–89. https://doi.org/10.5455/medarh.2022.76.84-89
Paessler, S., Huang, C., Sencanski, M., Veljkovic, N., Perovic, V., Glisic, S., & Veljkovic, V. (2018). Ibuprofen as a template molecule for drug design against Ebola virus. Frontiers in Bioscience - Landmark, 23(5), 947–953. https://doi.org/10.2741/4627
Powers, W. J., Derdeyn, C. P., Biller, J., Coffey, C. S., Hoh, B. L., Jauch, E. C., Johnston, K. C., Johnston, S. C., Khalessi, A. A., Kidwell, C. S., Meschia, J. F., Ovbiagele, B., & Yavagal, D. R. (2015). 2015 American Heart Association/American stroke association focused update of the 2013 guidelines for the early management of patients with acute ischemic stroke regarding endovascular treatment: A guideline for healthcare professionals from the American . Stroke, 46(10), 3020–3035. https://doi.org/10.1161/STR.0000000000000074
Putri et al. (2020). Correlation of Platelet Distribution Width (PDW) and Troponin I in Acute Myocardial Infarction. Journal of Endocrinology, Tropical Medicine, and Infectiouse Disease (JETROMI), 2(3), 124–132. https://doi.org/10.32734/jetromi.v2i3.4287
Riungu, J., Ronteltap, M., & van Lier, J. B. (2018). Build-up and impact of volatile fatty acids on E. coli and A. lumbricoides during co-digestion of urine diverting dehydrating toilet (UDDT-F) faeces. Journal of Environmental Management, 215, 22–31. https://doi.org/10.1016/j.jenvman.2018.02.076
Tampubolon, L. F., Ginting, A., & Saragi Turnip, F. E. (2023). Gambaran Faktor yang Mempengaruhi Kejadian Penyakit Jantung Koroner (PJK) di Pusat Jantung Terpadu (PJT). Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal, 13(3), 1043–1052. https://doi.org/10.32583/pskm.v13i3.1077
Thygesen, K., Alpert, J. S., Jaffe, A. S., Chaitman, B. R., Bax, J. J., Morrow, D. A., & White, H. D. (2018). Fourth Universal Definition of Myocardial Infarction (2018). Journal of the American College of Cardiology, 72(18), 2231–2264. https://doi.org/10.1016/j.jacc.2018.08.1038
WHO. (2016). WORLD HEALTH STATISTICS - MONITORING HEALTH FOR THE SDGs. World Health Organization, 1.121.
Wicaksono, S. (2020). Faktor Risiko Penyakit Jantung Koroner (PJK) Pada Pasien Rawat Inap Di Intensive Cardiovascular Care Unit (ICCU) RSUD DR M Yunus Bengkulu. Jurnal Kesmas Indonesia, 12(1), 26–32.
Yulendasari, R., Andoko, & Pradisca, R. A. (2020). Hubungan antara aktivitas fisik dan riwayat keluarga dengan kejadian jantung koroner di Puskesmas Banjarsari Kota Metro tahun 2020. Jurnal Ilmu Kesehatan Indonesia, 1(2), 1–7.
Zhang, H., Zheng, H., Guo, P., Hu, L., Wang, Z., Wang, J., Ju, Y., & Meng, S. (2021). Correction for Zhang et al., “Broadly Protective CD8 + T Cell Immunity to Highly Conserved Epitopes Elicited by Heat Shock Protein gp96-Adjuvanted Influenza Monovalent Split Vaccine” . Journal of Virology, 95(24), 2021. https://doi.org/10.1128/jvi.01750-21
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