CHARACTERISTICS OF BODY WEIGHT CHANGES IN PEDIATRIC TUBERCULOSIS RECEIVING ANTI-TUBERCULOSIS DRUGS AT PROF. DR. I.G.N.G. NGOERAH GENERAL HOSPITAL FROM 2021 TO 2024
DOI:
https://doi.org/10.31004/jkt.v6i3.47819Keywords:
berat badan, obat antituberkulosis, RSUP Prof. Dr. I.G.N.G. Ngoerah, status gizi, tuberkulosis anakAbstract
Penurunan berat badan merupakan salah satu gejala klinis yang umum pada anak penderita tuberkulosis (TB). Pemberian obat antituberkulosis (OAT) diharapkan tidak hanya menekan infeksi tetapi juga mendorong penambahan berat badan pada anak. Efektivitas pengobatan TB pada anak dapat dievaluasi melalui perbaikan gejala klinis dan penambahan berat badan. Namun, literatur tentang perubahan berat badan pada anak selama pengobatan TB masih terbatas. Penelitian ini bertujuan untuk mengetahui karakteristik perubahan berat badan pada pasien TB anak yang menerima OAT di RSUP Prof. Dr. I.G.N.G. Ngoerah. Penelitian ini merupakan penelitian deskriptif analitik dengan pendekatan potong lintang. Data dikumpulkan secara retrospektif menggunakan teknik total sampling melalui rekam medis dan registri pasien TB anak dari tahun 2021 hingga 2024. Analisis univariat dan bivariat digunakan dalam penelitian ini. Sebanyak 26 pasien TB anak berusia 0–18 tahun diikutsertakan, dengan mayoritas berusia 10–18 tahun dan proporsi perempuan yang sedikit lebih tinggi. Semua anak mengalami penambahan berat badan selama terapi OAT. Berat badan rata-rata meningkat secara signifikan di seluruh tahapan pengobatan (dari 28,75±11,94 kg menjadi 36,54±14,28 kg; p<0,001), dengan pertambahan tertinggi diamati selama fase intensif. Status gizi juga membaik secara signifikan, sebagaimana ditunjukkan oleh pergeseran skor-z rata-rata IMT/U dari rentang kurus parah menjadi normal (p<0,001). Terdapat peningkatan berat badan yang signifikan dan perbaikan status gizi pada akhir fase intensif dan fase lanjutan dibandingkan dengan awal pengobatan.References
Agustin, A. F. A., & Sulistyorini, L. 2023. Association of Contact History and Family Behavior with Tuberculosis in Children at Banyu Urip Public Health Center, Surabaya City, Indonesia: A Case-Control Study. Public Health and Preventive Medicine Archive, 11(2), 211–221. https://doi.org/10.53638/phpma.2023.v11.i2.p09
Agustina, B., Kartasasmita, C., & Hilmanto, D. 2019. Comparison of GeneXpert MTB to Mycobacterium tuberculosis culture in children with tuberculosis. Paediatrica Indonesiana(Paediatrica Indonesiana), 59(3), 113–118. https://doi.org/10.14238/pi59.3.2019.113-8
Amelia, S., & Kaswandani, N. 2024. Correlation Between Tuberculosis Type and Comorbidities with Nutritional Recovery Rates Post-Tuberculosis Treatment in Pediatric Patients. Archives of Pediatric Gastroenterology, Hepatology, and Nutrition, 3, 1. https://doi.org/https://doi.org/10.58427/apghn.3.3.2024.1-11
Aygün, D., Yıldırım, T., Öner, Ö. B., & Şiraneci, R. 2020. Evaluation of Clinical and Laboratory Characteristics of Childhood Tuberculosis. Turkish Archives of Pediatrics, 55(3), 236–243. https://doi.org/10.14744/TurkPediatriArs.2020.02438
Azzahra, F., Sofiah, F., Lestari, H. I., Alia, R. A. M., & Ayu, D. R. 2024. Comparison of Characteristics of Outpatient and Inpatient Child Pulmonary Tuberculosis Patients at Dr. Mohammad Hoesin Hospital Palembang. Jurnal RSMH Palembang, 5(2), 377–387.
Bansal, P., Mishra, S., & Ambey, R. 2023. Weight Gain Pattern in Children Below 14 Years Undergoing Antitubercular Therapy. International Journal of Toxicological and Pharmacological Research, 100–105. https://impactfactor.org/PDF/IJTPR/13/IJTPR,Vol13,Issue5,Article14.pdf
Baykan, A. H., Sayiner, H. S., Aydin, E., Koc, M., Inan, I., & Erturk, S. M. 2022. Extrapulmonary Tuberculosıs: An Old but Resurgent Problem. Dalam Insights into Imaging (Vol. 13, Nomor 1). Springer Science and Business Media Deutschland GmbH. https://doi.org/10.1186/s13244-022-01172-0
Centers for Disease Control and Prevention. 2024. Tuberculosis in Children. [online] Tuberculosis (TB). Available at: https://www.cdc.gov/tb/about/children.html [Accessed 28 Mar. 2024].
Dubois, M. M., Brooks, M. B., Malik, A. A., Siddiqui, S., Ahmed, J. F., Jaswal, M., Amanullah, F., Becerra, M. C., & Hussain, H. 2022. Age-specific Clinical Presentation and Risk Factors for Extrapulmonary Tuberculosis Disease in Children. Pediatric Infectious Disease Journal, 41(8), 620–625. https://doi.org/10.1097/INF.0000000000003584
Kementerian Kesehatan Republik Indonesia. 2023. Petunjuk Teknis Tata Laksana Tuberkulosis Anak dan Remaja. [online] Jakarta: Kementerian Kesehatan RI, pp.978–623301–4274. Available at: https://www.tbindonesia.or.id/wp-content/uploads/2024/02/Final-Petunjuk-Teknis-Tata-Laksana-TBC-Anak-dan-Remaja-2023.pdf [Accessed 10 May 2025].
Kementerian Kesehatan Republik Indonesia. 2024. Dashboard Data Kondisi TBC di Indonesia. [online]. Available at: https://tbindonesia.or.id/pustaka-tbc/dashboard/ [Accessed 3 May 2024].
Kibirige, L., Izudi, J., & Okoboi, S. 2021. Discontinuation of Tuberculosis Treatment Among Children in The Kampala Capital City Authority Health Facilities: A Mixed-methods Study. BMC Infectious Diseases, 21(1). https://doi.org/10.1186/s12879-021-06244-y
Kumar, G. S., Sameena, P., Karthik, V., & Ghanate, N. 2023. Prospective Study on Outcome of MDR-TB Using the Shorter Regimen During COVID-19 Pandemic. Journal of Family Medicine and Primary Care, 12(6), 1087–1091. https://doi.org/10.4103/jfmpc.jfmpc_1723_22
Laycock, K. M., Enane, L. A., & Steenhoff, A. P. 2021. Tuberculosis in Adolescents and Young Adults: Emerging Data on TB Transmission and Prevention Among Vulnerable Young People. Dalam Tropical Medicine and Infectious Disease (Vol. 6, Nomor 3). MDPI. https://doi.org/10.3390/TROPICALMED6030148
Liao, Q., Zheng, Y., Wang, Y., Ye, L., Liu, X., Jiao, W., Liu, Y., Zhu, Y., Jia, J., Sun, L., Shen, A., & Wan, C. 2022. Effectiveness of Bacillus Calmette-Guérin vaccination against severe childhood tuberculosis in China: a case-based, multicenter retrospective study. International Journal of Infectious Diseases, 121, 113–119. https://doi.org/10.1016/j.ijid.2022.04.023
Martinez, L., Cords, O., Liu, Q., Acuna-Villaorduna, C., Bonnet, M., Fox, G. J., Carvalho, A. C. C., Chan, P. C., Croda, J., Hill, P. C., Lopez-Varela, E., Donkor, S., Fielding, K., Graham, S. M., Espinal, M. A., Kampmann, B., Reingold, A., Huerga, H., Villalba, J. A., … Andrews, J. R. 2022. Infant BCG Vaccination and Risk of Pulmonary and Extrapulmonary Tuberculosis Throughout the Life Course: A Systematic Review and Individual Participant Data Meta-Analysis. The Lancet Global Health, 10(9), e1307–e1316. https://doi.org/10.1016/S2214-109X(22)00283-2
Mexitalia, M., Dewi, Y. O., Pramono, A., & Anam, M. S. 2017. Effect of Tuberculosis Treatment on Leptin Levels, Weight Gain, and Percentage Body Fat in Indonesian Children. Korean Journal of Pediatrics, 60(4), 118. https://doi.org/10.3345/kjp.2017.60.4.118
Padmapriyadarsini, C., Shobana, M., Lakshmi, M., Beena, T., & Swaminathan, S. 2016. Undernutrition & Tuberculosis in India: Situation Analysis & The Way Forward. Indian Journal of Medical Research, 144(1), 11. https://doi.org/10.4103/0971-5916.193278
Pratiwi, W., Toipah, I., Rachmawan, Y. P., & Reki, W. 2025. The Features of Children with Tuberculosis at Sidawangi Pulmonary Hospital in Indonesia: Interactions within the Home as a Potential Transmission Risk. GHMJ (Global Health Management Journal), 8(1), 55–61. https://doi.org/10.35898/ghmj-811203
Sari, R. O., & Prabowo, B. 2023. Characteristics of Pediatric Tuberculosis Patients at Simpang Lima Gumul Hospital, Kediri, East Java. Asian Journal of Health Research, 2(2), 10–15. https://doi.org/10.55561/ajhr.v2i2.110
Sazali, M. F., Rahim, S. S. S. A., Mohammad, A. H., Kadir, F., Payus, A. O., Avoi, R., Jeffree, M. S., Omar, A., Ibrahim, M. Y., Atil, A., Tuah, N. M., Dapari, R., Lansing, M. G., Rahim, A. A. A., & Azhar, Z. I. 2023. Improving Tuberculosis Medication Adherence: The Potential of Integrating Digital Technology and Health Belief Model. Dalam Tuberculosis and Respiratory Diseases (Vol. 86, Nomor 2, hlm. 82–93). Korean National Tuberculosis Association. https://doi.org/10.4046/trd.2022.0148
Setyoningrum, R. A., Maharani, R. A., Hapsari, R., & Chafid, A. P. P. 2024. Risk Factors of Tuberculosis in Children with Adult Household Tuberculosis Contact. Paediatrica Indonesiana(Paediatrica Indonesiana), 64(4), 287–292. https://doi.org/10.14238/pi64.4.2024.287-92
Shodikin, M. A., Nastiti Ayu, P. P., & Handoko, A. 2021. Hubungan Riwayat Tuberkulosis Paru pada Keluarga dengan Terjadinya Limfadenitis Tuberkulosis pada Anak. Jurnal Kesehatan Masyarakat Indonesia, 16(3), 168. https://doi.org/10.26714/jkmi.16.3.2021.168-176
Siddalingaiah, N., Chawla, K., Nagaraja, S. B., & Hazra, D. 2023. Risk Factors for The Development of Tuberculosis Among The Pediatric Population: A Systematic Review and Meta-analysis. Dalam European Journal of Pediatrics (Vol. 182, Nomor 7, hlm. 3007–3019). Springer Science and Business Media Deutschland GmbH. https://doi.org/10.1007/s00431-023-04988-0
Singh, S., Chegondi, M., Chacham, S., Kumar, P., & Goyal, J. P. 2021. Comparison of Clinical and Laboratory Profile of Pulmonary and Extrapulmonary Tuberculosis in Children: A Single-Center Experience from India. Journal of Clinical and Translational Research, 7(4), 423–427. https://doi.org/10.18053/jctres.07.202104.004
Soekotjo, F. N., Sudarwati, S., & Alam, A. 2019. Clinical Profile of TB in Children at Pediatric Outpatient Clinic Hasan Sadikin Hospital Bandung 2016. Journal of Medicine & Health, 2(3). https://doi.org/10.28932/jmh.v2i3.1221
Tenribali, A. W. Y., Jafar, M. A., Ratnawati, W., Darussalam, A. H. E., & Nikmawati. 2024. Characteristics Of Childhood Tuberculosis Patients At La Palaloi Maros Regional Hospital-Andi We Yada Tenribali et.al Characteristics Of Childhood Tuberculosis Patients At La Palaloi Maros Regional Hospital. Jurnal EduHealth, 15, 2024. https://doi.org/10.54209/eduhealth.v15i02
World Health Organization. 2022. Global Tuberculosis Report 2022. [online]. Available at: https://www.who.int/publications/i/item/9789240061729 [Accessed 16 Sep. 2023].
World Health Organization. 2024. Tuberculosis. [online] Available at: https://www.who.int/health-topics/tuberculosis#tab=tab_1 [Accessed 3 Jan. 2024].
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