LITERATUR REVIEW : SKRINING FITOKIMIA DAN AKTIVITAS FARMAKOLOGI ANGGUNI (CHROMOLAENA ODORATA)

Authors

  • Auliah Rahmi Latif Fakultas Ilmu Kesehatan, Universitas Sulawesi Barat
  • Irna Megawaty Fakultas Ilmu Kesehatan, Universitas Sulawesi Barat

DOI:

https://doi.org/10.31004/jkt.v6i2.45991

Keywords:

Chromolaena odorata, skrining fitokimia, aktivitas farmakologi, metabolit sekunder

Abstract

Chromolaena odorata merupakan spesies invasif familia Asteraceae yang memiliki potensi signifikan sebagai sumber metabolit bioaktif namun belum terkarakterisasi secara komprehensif. Tujuan menganalisis profil fitokimia dan spektrum aktivitas farmakologi daun C. odorata . Metode: Narrative review dilakukan terhadap publikasi periode 2021-2025 menggunakan basis data PubMed, ScienceDirect, Scopus, dan Google Scholar dengan kata kunci "Chromolaena odorata", "skrining fitokimia", "aktivitas farmakologi", dan varian terminologi terkait. Analisis tematik diterapkan untuk mengidentifikasi pola kandungan fitokimia dan aktivitas farmakologinya. Artikel publikasi primer memenuhi kriteria inklusi, mengungkapkan diversitas fitokimia kompleks meliputi flavonoid alkaloid, saponin, tanin, terpenoid, steroid, dan kuinon. Aktivitas antioksidan, antimikroba,  efek neuropsikofarmakolog, aktivitas ansiolitik dan antidepresan.Kesimpulan: C. odorata mengandung spektrum luas metabolit sekunder dengan aktivitas farmakologi multidimensional, memberikan potensi translasional signifikan untuk pengembangan fitofarmaka inovatif dengan persyaratan standardisasi dan optimalisasi formulasi.  

References

Ajay, A., Kumar, R. M., Badhusha, S. P., Baby, B., Gowda, S. K., & Ramesh, B. (2021). Pharmacological Importance of Chromolaena odorata: a review. International Journal of Pharmaceutics Dan Drug Analysis, 9(1). https://doi.org/10.47957/ijpda

Alang, H., Hastuti, & Yusral, M. S. (2021). Pemanfaatan Tumbuhan Sekitar Sebagai Obat Tradisional Bagi Warga Desa Puundoho Kab. Kolaka Utara. 2(1), 75–81.

Aulia, A., & Umam, K. (2022a). Antibacterial Screenings of Chromolaena odorata L. and its potential against Staphyloccocus aureus, Bacillus subtilis, Staphyloccocus typhimurium, and Escherhicia coli in Sumbawa. Jurnal Biologi Tropis, 22(3), 1077–1083. https://doi.org/10.29303/jbt.v22i3.4220

Aulia, A., & Umam, K. (2022b). Antibacterial Screenings of Chromolaena odorata L. and its potential against Staphyloccocus aureus, Bacillus subtilis, Staphyloccocus typhimurium, and Escherhicia coli in Sumbawa. Jurnal Biologi Tropis, 22(3), 1077–1083. https://doi.org/10.29303/jbt.v22i3.4220

Dewantari, R., Lintang, M. L., & Nurmiyati. (2018). Jenis Tumbuhan yang Digunakan sebagai Obat Tradisional Di Daerah EksKaresidenan Surakarta. Bioedukasi, 11, 118–123.

Dougnon, G., & Ito, M. (2021a). Essential oil from the leaves of chromolaena odorata, and sesquiterpene caryophyllene oxide induce sedative activity in mice. Pharmaceuticals, 14(7). https://doi.org/10.3390/ph14070651

Dougnon, G., & Ito, M. (2021b). Essential oil from the leaves of chromolaena odorata, and sesquiterpene caryophyllene oxide induce sedative activity in mice. Pharmaceuticals, 14(7). https://doi.org/10.3390/ph14070651

Elisma, E., Rahman, H., & Lestari, U. (2020). Ppm Pemberdayaan Masyarakat Dalam Pengolahan Tanaman Obat Sebagai Obat Tradisional Di Desa Mendalo Indah Jambi Luar Kota. SELAPARANG Jurnal Pengabdian Masyarakat Berkemajuan, 4(1), 274. https://doi.org/10.31764/jpmb.v4i1.2736

Eze, F. N., & Jayeoye, T. J. (2021a). Chromolaena odorata (Siam weed): A natural reservoir of bioactive compounds with potent anti-fibrillogenic, antioxidative, and cytocompatible properties. Biomedicine and Pharmacotherapy, 141(March), 111811. https://doi.org/10.1016/j.biopha.2021.111811

Eze, F. N., & Jayeoye, T. J. (2021b). Chromolaena odorata (Siam weed): A natural reservoir of bioactive compounds with potent anti-fibrillogenic, antioxidative, and cytocompatible properties. Biomedicine and Pharmacotherapy, 141. https://doi.org/10.1016/j.biopha.2021.111811

Eze, I. L., Onyegbule, F. A., Ezugwu, C. O., Chibuzor, J. V., & Aziakpono, O. M. (2024). Phytochemical and Antioxidant Evaluations of Chromolaena odorata and Huntaria umbellata. Journal of Pharmaceutical Research International, 36(12), 213–224. https://doi.org/10.9734/jpri/2024/v36i127641

Gultom, E. S., Sakinah, M., & Hasanah, U. (2020a). Eksplorasi Senyawa Metabolit Sekunder Daun Kirinyuh (Chromolaena odorata) dengan GC-MS. Jurnal Biosains, 6(1), 23–26.

Gultom, E. S., Sakinah, M., & Hasanah, U. (2020b). Eksplorasi Senyawa Metabolit Sekunder Daun Kirinyuh (Chromolaena odorata) DENGAN GC-MS. Jurnal Biosains, 6(1). https://doi.org/10.24114/jbio.v6i1.16450

Helmina, S., & Hidayah, Y. (2021). Kajian etnobotani tumbuhan obat tradisional oleh masyarakat kampung padang kecamatan sukamara kabupaten sukamara. Jurnal Pendidikan Hayati, 7(1), 20–28.

Ismunarti, D. H., Zainuri, M., Sugianto, D. N., & Saputra, S. W. (2020). Pengujian Reliabilitas Instrumen Terhadap Variabel Kontinu Untuk Pengukuran Konsentrasi Klorofil- A Perairan. Buletin Oseanografi Marina, 9(1), 1–8. https://doi.org/10.14710/buloma.v9i1.23924

Kanji, M. A., Oladapo, O. E., Adedeji, O. F., Muyiwa, F. S., & Adedeji, O. H. (2025). Unravelling the anxiolytic and antidepressant potential of choromolaena odorata extaract a preclinical inverstig-annotated. West African Journal of Pharmacy , 36(1), 109–121.

Lucky, I., Ahamefule, F., Obodike, C., Victor, J., & Moses, O. (2024). Phytochemical and Antioxidant Evaluations of Chromolaena odorata and Huntaria umbellata. 36(12), 213–224.

Marsella, V. R., & Saleh, C. (2024). Review Artikel : Identifikasi Fitokimia , Potensi Aktivitas Antioksidan Dan Toksisitas Daun Balakacida ( Chromolaena odorata L .) Article Review : Phytochemical Identification , Potential Antioxidant Activity And Toxicity Of Balakacida Leaves ( Chromolaen. 239–242.

Murtala. (2025). Unraveling The Anxiolytic and Antidepressany Potential Of Chromolaena Odorata Extract: a Precelinical Invvestagation.

Odion, mmanuel E., Amber, D. A., Idiakose, G. O., & Odiete, E. E. (2023). Phytochemical screening, proximate analysis and Chromatographic analysis of methanol leaf extract of Chromolaena odorata (L.) M.King & H.Rob. (Asteraceae). West African Journal of Pharmacy , 34(2), 44–54.

R. Hedi, D. (2017). Pengembangan Obat Tradisional Indonesia menjadi Fitofarmaka. Majalah Kedokteran Indonesia, 57(7), 205–210.

Rahayu, S. (2021). Pemanfaatan Tanaman Kelor (Moringa Oleifera) Sebagai Obat Tradisional Di Dusun Aek Kulim Mandalasena Kabupaten Labuhanbatu Selatan. Bioscientist : Jurnal Ilmiah Biologi, 9(1), 63–71.

Ramdhayani, A. N., Syamswisna, S., & Fajri, H. (2023). Pemanfaatan Tumbuhan Obat Tradisional Masyarakat Desa Semata Kecamatan Tangaran Kabupaten Sambas. Bioscientist : Jurnal Ilmiah Biologi, 11(1), 330. https://doi.org/10.33394/bioscientist.v11i1.7286

Marsella, V. R., & Saleh, C. (2024). Review Artikel: Identifikasi Fitokimia, Potensi Aktivitas Antioksidan Dan Toksisitas Daun Balakacida(Chromolaena odorata L.).

Siregar, R. S., Tanjung, A. F., Siregar, A. F., Bangun, I. H., & Mulya, M. O. (2020). Studi Literatur Tentang Pemanfaatan Tanaman Obat Tradisional. April 2023, 7.

Tahar, M., Nurmalasari, Haliza, N., Asifa, N., & Atika, N. (2024). Pemanfaatan Tanaman Obat Tradisional Oleh Masyarakat Polewali Mandar Sulawesi Barat dan Studi Literatur Aktivitas Farmakologinya. JIIC: Jurnal Intelek Insan Cendikia, 1. https://jicnusantara.com/index.php/jiic

Vera, Y., & Yanti, S. (2020). Penyuluhan pemanfaatan tanaman obat dan obat tradisional Indonesia untuk pencegahan dan penanggulangan penyakit hipertensi di Desa Salam Bue. Jurnal Education and Development, 8(1), 11–14.

Downloads

Published

2025-06-08

Issue

Vol. 6 No. 2 (2025): JUNI 2025

Section

Articles

License

Copyright (c) 2025 Auliah Rahmi Latif, Irna Megawaty

Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Authors who publish with this journal agree to the following terms:

  • Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work’s authorship and initial publication in this journal.
  • Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal’s published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  • Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).