EXPLORING THE POTENTIAL OF LIPID COMPOUNDS FROM SEAWEEDS IN ENHANCING SUN PROTECTING FACTOR (SPF) : A LITERATURE REVIEW
DOI:
https://doi.org/10.31004/jkt.v6i2.45449Keywords:
Rumput laut, Senyawa turunan lipid, SPF, fotoprotektifAbstract
Rumput laut merupakan sumber alami senyawa bioaktif dengan potensi fotoprotektif, termasuk senyawa berbasis lipid termasuk lipid polar maupun non polar seperti asam lemak, karotenoid, sterol, steroid, dan triterpenoid. Kelompok senyawa ini dapat menyerap radiasi ultraviolet (UV), dan menetralkan radikal bebas, sehingga dapat melindungi kulit dari paparan sinar matahari dan mencegah terjadinya berbagai bentuk permasalahan kulit seperti penuaan dini (photoaging), hiperpegentasi, sunburn hingga kanker kulit. Tinjauan pustaka ini bertujuan untuk mengevaluasi potensi senyawa lipid dari berbagai spesies rumput laut dalam meningkatkan aktivitas Sun Protection Factor (SPF). Metode narrative review digunakan pada artikel review ini dengan menganalisis berbagai artikel penelitian yang memenuhi kriteria inklusi, yaitu diterbitkan antara tahun 2015 dan 2025, berasal dari jurnal terakreditasi SINTA atau terindeks Scopus, serta ditulis dalam bahasa Indonesia atau bahasa Inggris. Artikel yang tidak mencantumkan data uji SPF secara jelas, tidak meneliti senyawa lipid, atau hanya membahas metabolit lain seperti polisakarida dan protein dieksklusi dari tinjauan ini. Hasil review menunjukkan bahwa senyawa lipid seperti asam lemak (EPA, DHA), fucoxanthin, steroid, gliserol, dan terpenoid dari rumput laut menunjukkan aktivitas fotoprotektif yang menjanjikan, terutama saat diekstraksi menggunakan pelarut non-polar seperti n-heksan. Artikel ini berfokus pada potensi lipid dari rumput laut sebagai bahan aktif dalam formulasi tabir surya alami.References
Abdullah, A., Nurjanah, N., & Irma Suryani Nasution, A. (2021). Karakteristik Fraksi Aktif Biopigmen Fukosantin Rumput Laut Cokelat sebagai Antioksidan dan UV-protector. Jurnal Pengolahan Hasil Perikanan Indonesia, 24(1), 131–147. https://doi.org/10.17844/jphpi.v24i1.35411
Achmadi, R., & Arisandi, A. (2021). PERBEDAAN DISTRIBUSI ALGA COKLAT (Sargassum sp.) DI PERAIRAN PANTAI SRAU DAN PIDAKAN KABUPATEN PACITAN. Juvenil:Jurnal Ilmiah Kelautan Dan Perikanan, 2(1), 25–31. https://doi.org/10.21107/juvenil.v2i1.9766
Arsa, A. K., & Achmad, Z. (2020). Ekstraksi Minyak Atsiri dari Rimpang Temu Ireng (Curcuma aeruginosa Roxb) dengan Pelarut Etanol dan N-Heksana. Jurnal Teknologi Technoscientia, 13(1), 83–94.
Arsianti, A. A., Fadilah, F., Fatmawaty, Y., Wibisono, L. K., Kusmardi, S., Azizah, N. N., Putrianingsih, R., Murniasih, T., Rasyid, A., & Pangestuti, R. (2016). Phytochemical composition and anticancer activity of seaweeds Ulva lactuca and Eucheuma cottonii against breast MCF-7 and colon HCT-116 cells. Asian Journal of Pharmaceutical and Clinical Research, 9(6), 115–119. https://doi.org/10.22159/ajpcr.2016.v9i6.13798
Chen, H., Lin, Q., Zeng, Y., Chen, P., Guo, P., Feng, R., Guo, Z., Kang, J., Chen, Q., & Zhou, X. (2025). Xinyin tablets affect mitophagy and cardiomyocyte apoptosis to alleviate chronic heart failure by regulating histone deacetylase 3(HDAC3)-mediated PTEN induced putative kinase 1(PINK1)/Parkin signaling pathway. Journal of Ethnopharmacology, 346(16), 119666. https://doi.org/10.1016/j.jep.2025.119666
Cian, R. E., Drago, S. R., De Medina, F. S., & Martínez-Augustin, O. (2015). Proteins and carbohydrates from red seaweeds: Evidence for beneficial effects on gut function and microbiota. Marine Drugs, 13(8), 5358–5383. https://doi.org/10.3390/md13085358
Crous, C., Pretorius, J., & Petzer, A. (2024). Overview of popular cosmeceuticals in dermatology. Skin Health and Disease, 4(2). https://doi.org/10.1002/ski2.340
Dolorosa, Maretty Twentyna Nurjanah, Purwaningsih, Sri, Anwar, Effionora, Hidayat, T. (2017). KANDUNGAN SENYAWA BIOAKTIF BUBUR RUMPUT LAUT Sargassum plagyophyllum DAN Eucheuma cottonii SEBAGAI BAHAN BAKU KRIM PENCERAH KULIT. Journal.Ipb.Ac.Id/Index.Php/Jphpi, 20(December). https://doi.org/10.17844/jphpi.v20i3.19820
Freitas, R., Martins, A., Silva, J., Alves, C., Pinteus, S., Alves, J., Teodoro, F., Ribeiro, H. M., Gonçalves, L., Petrovski, Ž., Branco, L., & Pedrosa, R. (2020). Highlighting the biological potential of the brown seaweed fucus spiralis for skin applications. Antioxidants, 9(7), 1–21. https://doi.org/10.3390/antiox9070611
Gęgotek, A., Łuczaj, W., & Skrzydlewska, E. (2021). Effects of natural antioxidants on phospholipid and ceramide profiles of 3d-cultured skin fibroblasts exposed to uva or uvb radiation. Antioxidants, 10(4), 1–18. https://doi.org/10.3390/antiox10040578
Hamed, I., Özogul, F., Özogul, Y., & Regenstein, J. M. (2015). Marine Bioactive Compounds and Their Health Benefits: A Review. Comprehensive Reviews in Food Science and Food Safety, 14(4), 446–465. https://doi.org/10.1111/1541-4337.12136
Hunt, L., Klem, K., Lhotáková, Z., Vosolsobě, S., Oravec, M., Urban, O., Špunda, V., & Albrechtová, J. (2021). Light and co2 modulate the accumulation and localization of phenolic compounds in barley leaves. Antioxidants, 10(3), 1–22. https://doi.org/10.3390/antiox10030385
Hwang, E., Park, S. Y., Sun, Z. wang, Shin, H. S., Lee, D. G., & Yi, T. H. (2014). The Protective Effects of Fucosterol Against Skin Damage in UVB-Irradiated Human Dermal Fibroblasts. Marine Biotechnology, 16(3), 361–370. https://doi.org/10.1007/s10126-013-9554-8
Kalasariya, H. S., Pereira, L., & Patel, N. B. (2022). Pioneering Role of Marine Macroalgae in Cosmeceuticals. Phycology, 2(1), 172–203. https://doi.org/10.3390/phycology2010010
Kasitowati, R. D., Huda, M. M., Asmara, R., Aliviyanti, D., Iranawati, F., Panjaitan, M. A. P., Pratiwi, D. C., & Arsad, S. (2021). Identifikasi potensi fotoprotektif ekstrak rumput laut cokelat Sargassum sp. dengan variasi pelarut terhadap paparan sinar ultraviolet secara in vitro. Indonesian Journal of Fisheries Science and Technology, 17(1), 7–14. http://ejournal.undip.ac.id/index.php/saintek
Kim, S. M., Jung, Y. J., Kwon, O. N., Cha, K. H., Um, B. H., Chung, D., & Pan, C. H. (2012). A potential commercial source of fucoxanthin extracted from the microalga Phaeodactylum tricornutum. Applied Biochemistry and Biotechnology, 166(7), 1843–1855. https://doi.org/10.1007/s12010-012-9602-2
Kirindage, K. G. I. S., Jayasinghe, A. M. K., Ko, C. I., Ahn, Y. S., Heo, S. J., Kim, E. A., Cho, N. K., & Ahn, G. (2024). Photoprotective Effect of Ultrasonic-Assisted Ethanol Extract from Sargassum horneri on UVB-Exposed HaCaT Keratinocytes. Antioxidants, 13(11). https://doi.org/10.3390/antiox13111342
Lopes, D., Rey, F., Leal, M. C., Lillebø, A. I., Calado, R., & Domingues, M. R. (2021). Bioactivities of lipid extracts and complex lipids from seaweeds: Current knowledge and future prospects. Marine Drugs, 19(12), 1–24. https://doi.org/10.3390/md19120686
Meinita, M. D. N., Harwanto, D., Tirtawijaya, G., Negara, B. F. S. P., Sohn, J. H., Kim, J. S., & Choi, J. S. (2021). Fucosterol of marine macroalgae: Bioactivity, safety and toxicity on organism. Marine Drugs, 19(10). https://doi.org/10.3390/md19100545
Milani, M., & Sparavigna, A. (2017). The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: An intra-subject, randomized, assessor-blinded study. Clinical, Cosmetic and Investigational Dermatology, 10, 311–315. https://doi.org/10.2147/CCID.S144180
Morais, T., Inácio, A., Coutinho, T., Ministro, M., Cotas, J., Pereira, L., & Bahcevandziev, K. (2020). Seaweed potential in the animal feed: A review. Journal of Marine Science and Engineering, 8(8), 1–24. https://doi.org/10.3390/JMSE8080559
Natarajan, J., Krishnan, P., Arokianathan, S. S., & Sivakumar, S. (2025). A Sunscreen Based on Avobenzone Loaded in Solid Lipid Nanoparticles for Enhanced Sun Protection. 15(2), 490–497. https://doi.org/10.5530/ijpi.20250087
Nkurunziza, D., Coad, B. R., & Bulone, V. (2025). A review on integrated biorefining of brown algae focusing on bioactive compounds and holistic biomass valorisation. Journal of Industrial and Engineering Chemistry. https://doi.org/10.1016/j.jiec.2025.03.047
Nwanodi, O. (2018). Skin protective nutraceuticals: The current evidence in brief. Healthcare (Switzerland), 6(2). https://doi.org/10.3390/healthcare6020040
Of, V., & Methods, E. (2021). Variasi Metode Ekstraksi Dan Penetapan Nilai SPF Sediaan Lotion Ekstrak Rumput Laut Merah ( Eucheuma cottonii ). 9(1), 31–43.
Prasedya, E. S., Frediansyah, A., Martyasari, N. W. R., Ilhami, B. K., Abidin, A. S., Padmi, H., Fahrurrozi, Juanssilfero, A. B., Widyastuti, S., & Sunarwidhi, A. L. (2021). Effect of particle size on phytochemical composition and antioxidant properties of Sargassum cristaefolium ethanol extract. Scientific Reports, 11(1), 1–9. https://doi.org/10.1038/s41598-021-95769-y
Putri, Dewi Kartika, Nora Idiawati, M. S. J. S. (2022). KANDUNGAN FITOKIMIA DAN NILAI SUN PROTECTION FACTORS (SPF) PADA EKSTRAK METANOL Hypnea pannosa, Turbinaria decurrens, DAN Caulerpa serrulata. Indonesian Journal of Pure and Applied Chemistry, 5(2), 65–72. doi: http://dx.doi.org/10.26418/indonesian.v5i2.49170
Ramdani, Yuyun, A. Dwi Ananto, W. H. (2021). Variasi Metode Ekstraksi Dan Penetapan Nilai SPF Sediaan Lotion Ekstrak Rumput Laut Merah ( Eucheuma cottonii ) Variation Of Extraction Methods And Determination Of SPF Value. 9(1), 31–43. https://doi.org/https://doi.org/ 10.20884/1.api.2021.9.1.4001
Saini, R. K., Prasad, P., Shang, X., Keum, Y.-S., & Parinandi, L. (2021). Molecular Sciences Advances in Lipid Extraction Methods-A Review. Int. J. Mol. Sci, 22, 13643. https://doi.org/10.3390/ijms222413643
Sami, F. J., Soekamto, N. H., & Latip, J. (2021). Bioactivity profile of three types of seaweed as an antioxidant, UV-protection as sunscreen and their correlation activity. 5(February), 441–447.
Sari, D. S. P., Saputra, E., & Alamsjah, M. A. (2019). Potential of fucoxanthin content in sargassum sp. On sunscreen cream preparation. International Journal of Recent Technology and Engineering, 7(6), 448–451.
Surya, T., Dasar, B., & Laut, R. (2021). FORMULASI , EVALUASI MUTU FISIK , DAN UJI SPF KRIM. 25(April), 15–19. https://doi.org/10.20956/mff.v25i1.11967
Sutedjo, I. R., Putri, H., & Meiyanto, E. (2016). Ekstrak etanolik awar-awar (Ficus septica) sebagai agen kemopreventif selektif pada berbagai macam sel kanker. NurseLine Journal, 1(2), 190–197.
Wikanta, T., Januar, H. I., & Nursid, M. (2017). UJI AKTIVITAS ANTIOKSIDAN, TOKSISITAS, DAN SITOTOKSISITAS EKSTRAK ALGA MERAH Rhodymenia palmata. Jurnal Penelitian Perikanan Indonesia, 11(4), 41. https://doi.org/10.15578/jppi.11.4.2005.41-49
Yanuarti, Rini Nurjanah. Anwar, Effionora.Pratama, G. (2017). Kandungan Senyawa Penangkal Sinar Ultra Violet dari Ekstrak Rumput Laut Eucheuma cottonii dan Turbinaria conoides. 34(2), 51–58. https://doi.org/10.20884/1.mib.2017.34.2.467
Zavella, Y. A. (2018). UJI MUTU FISIK GEL EKSTRAK ALGA MERAH ( Eucheuma cottonii ) DENGAN VARIASI KONSENTRASI EKSTRAK 0 , 5 % DAN 1 %. Doctoral Dissertation, Akademi Farmasi Putera Indonesia Malang), 1–8.
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