TINJAUAN PUSTAKA : ADENOMA TIROID, DEFINISI HINGGA PROGNOSIS
DOI:
https://doi.org/10.31004/jkt.v6i2.39270Keywords:
Adenoma tiroid, Diagnosis, Faktor resiko, TatalaksanaAbstract
Kelenjar tiroid merupakan kelenjar endokrin terbesar di dalam tubuh manusia yang dapat mengalami kelainan seperti lesi. Lesi diperkirakan 4-7% yang menderita. Lesi pada tiroid kebanyakan bersifat non kanker salah satunya adalah adenoma tiroid. Adenoma tiroid dapat disebabkan oleh banyak faktor seperti faktor lingkungan, mutasi genetik, defisiensi yodium, pemakaian radiologi yang berlebihan, pemeriksaan pada adenoma dapat dilakukan dengan pemeriksaan fisik dan pemeriksaan laboratorium. Metode penelitian ini menggunakan metode pendekatan naratif yang membahas mengenai artikel yang didapat atau review artikel dengan menggumpulkan data dari basis data online seperti Google Scholar, PubMed, ScienceDirect, Frontiers dan MDPI yang sumber literatur didapatkan dari rentang waktu 2011-2024. Kajian ini dilakukan secara menyeluruh mulai dari definisi, etiologi, faktor risiko, epidemiologi, patofisiologi, manifestasi klinis, diagnosis, tatalaksana, komplikasi dan prognosis dari penyakit adenoma tiroid. Berdasarkan hasil literatur yang didapatkan adenoma tiroid merupakan penyakit yang keberadaan tidak kita sadari dan biasanya terdiagnosis ketika melakukan pemeriksaan lain. Meskipun prognosis pada adenoma tiroid cenderung baik namun Anamnesis, pemeriksaan fisik dan pemeriksaan laboratorium secara menyeluruh penting dalam mendiagnosis adenoma tiroid agar tidak terjadi komplikasi yang mengarah kepada keganasan. Kesimpulan dari tinjauan pustaka ini adalah pengetahuan terkait adenoma tiroid seperti etiologi, faktor risiko, diagnosis dan penatalaksanaannya sangat penting dalam mendeteksi sekaligus dapat mengobati adenoma tiroid serta dapat mencegah komplikasi yang muncul.References
Derwahl, M., & Nicula, D. (2014). Estrogen and its role in thyroid cancer. Endocrine Related Cancer, 273–283. https://doi.org/10.1530/ERC-14-0053
Durante, C., Hegedüs, L., Durante, C., Hegedüs, L., Czarniecka, A., Paschke, R., & Russ, G. (2023). 2023 European Thyroid Association Clinical Practice Guidelines for thyroid nodule management. European Thyroid Journal. https://doi.org/https://doi.org/10.1530/ETJ-23-0067
Gerus, S., Rasiewicz, M., & Baglaj, M. (2020). Follicular adenoma of the thyroid gland in children: a clinical spectrum. Archives of Medical Science, 1–6. https://doi.org/DOI: https://doi.org/10.5114/aoms/130994
Harbuwono, D. S., Soewondo, P., Yunir, E., Soebardi, S., Darmowidjojo, B., Purnamasari, D., Tarigan, T. J. ., Wisnu, W., Tahapary, D. L., Yulian, E. D., Lisnawati, Stephaniem, A., Makes, B., Zulkarnain, B., Suroyo, I., Siswoyo, A. D., Gondhowiardjo, S., Kodrat, H., Hermani, B., … Subekti, I. (2019). Diagnostic approach to thyroid nodules. Indonesia Journal of Interna Med, 51(2), 189–193. https://doi.org/10.21276/aimdr.2016.2.6.pt1
Haugen, B. R., Alexander, E. K., Bible, K. C., Doherty, G. M., Mandel, S. J., Nikiforov, Y. E., Pacini, F., Randolph, G. W., Sawka, A. M., Schlumberger, M., Schuff, K. G., Sherman, S. I., Sosa, J. A., Steward, D. L., Tuttle, R. M., & Wartofsky, L. (2016). 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid, 26(1), 1–133. https://doi.org/10.1089/thy.2015.0020
Kant, R., Davis, A., & Verma, V. (2020). Thyroid Nodules : Advances in Evaluation and Management. American Academy of Family Physicians, 102(5), 298–304.
Lam, S., & Lang, B. H.-H. (2014). A Review of the Pathogenesis and Management of Multinodular Goiter. InTech. https://doi.org/10.5772/57547
Lunardhi, J. H. (2020). Papillary Lesions In The Thyroid Gland; - Interesting Facts. Widya Medika, 6(1), 1–6. https://doi.org/https://doi.org/10.33508/jwm.v6i1.2498
Mariani, G., Tonacchera, M., Grosso, M., Orsolini, F., Vitti, P., & Strauss, H. W. (2021). The role of nuclear medicine in the clinical management of benign thyroid disorders, part 1: Hyperthyroidism. Journal of Nuclear Medicine, 62(3), 304–312. https://doi.org/10.2967/jnumed.120.243170
McHenry, C. R., & Phitayakorn, R. (2011). Follicular Adenoma and Carcinoma of the Thyroid Gland. The Oncologist, 16(5), 585–593. https://doi.org/10.1634/theoncologist.2010-0405
Nguyen, D., Htun, N. N., & Wang, B. (2023). Follicular adenoma with bizarre nuclei and wild-type P53 expression: A case report and literature review. Rare Tumors, 15, 1–4. https://doi.org/10.1177/20363613231212383
Ospina, N. S., Maraka, S., Espinosa de Ycaza, A. E., Brito, J. P., Castro, M. R., Morris, J. C., & Montori, V. M. (2016). Prognosis of patients with benign thyroid nodules: a population-based study. Endocrine, 54(1), 148–155. https://doi.org/10.1007/s12020-016-0967-9
Pramudita, N., & Kusuma, A. A. G. B. (2021). Diagnosis dan penatalaksanaan nodul tiroid tunggal: Sebuah laporan kasus. Intisari Sains Medis, 12(3), 677–681. https://doi.org/10.15562/ism.v12i3.1099
Rong, Y., Torres-Luna, C., Tuszynski, G., Siderits, R., & Chang, F. N. (2023). Differentiating Thyroid Follicular Adenoma from Follicular Carcinoma via G-Protein Coupled Receptor-Associated Sorting Protein 1 (GASP-1). Cancers, 15(13), 1–11. https://doi.org/https://doi.org/10.3390/cancers15133404
Saglietti, C., Piana, S., La Rosa, S., & Bongiovanni, M. (2017). Hyalinizing trabecular tumour of the thyroid: Fine-needle aspiration cytological diagnosis and correlation with histology. Journal of Clinical Pathology, 70(8), 641–647. https://doi.org/10.1136/jclinpath-2017-204360
Setiati, S., Alwi, I., Sudoyo, A. W., Simdibrata K, M., Setiyohadi, M., & Syam, A. F. (2014). Buku Ajar Ilmu Penyakit Dalam. InternaPublishing.
Simsir, I. Y., Cetinkalp, S., & Kabalak, T. (2020). Review of Factors Contributing to Nodular Goiter and Thyroid Carcinoma. Medical Principles and Practice, 29(1), 1–5. https://doi.org/10.1159/000503575
Tamhane, S., & Gharib, H. (2016). Thyroid nodule update on diagnosis and management. Clinical Diabetes and Endocrinology, 2(1), 1–10. https://doi.org/10.1186/s40842-016-0035-7
Uppal, N., Collins, R., & James, B. (2023). Thyroid nodules: Global, economic, and personal burdens. Frontiers in Endocrinology, 1–5. https://doi.org/10.3389/fendo.2023.1113977
Vanderpump, M. P. J. (2011). The epidemiology of thyroid disease. British Medical Bulletin, 39–51. https://doi.org/10.1093/bmb/ldr030
Xie, C., Cox, P., Taylor, N., & LaPorte, S. (2016). Ultrasonography of thyroid nodules: a pictorial review. Insights into Imaging, 7(1), 77–86. https://doi.org/10.1007/s13244-015-0446-5
Yan, Y., Dong, J., Li, S., Yang, G., Huang, K., & Tian, W. (2023). Risk factors associated with the prevalence of thyroid nodules in adults sectional in Northeast China : a cross- population- based study. BMJ, 1–8. https://doi.org/10.1136/bmjopen-2022-069390
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Copyright (c) 2025 Putra Ragad, Muhammad Awallul Rizky Aritiah, Muhammad Hilman Rizaldi, Andi Muhammad Al Fatih Haq, Lazuardy Arsy, Alifia Amanda Larasati, Fairuz Karlina, Ni Wayan Devian Aishwarya, Alya Syafa Kamila, Ni Putu Ayu Nindya Dewi Cahya Putri

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