POTENSI ERITROPOIETIN : IMPLIKASI TERAPEUTIK SELAIN ANEMIA GAGAL GINJAL KRONIS (GGK)
DOI:
https://doi.org/10.31004/jkt.v6i1.38869Keywords:
Eritropoietin, implikasi, anemiaAbstract
Eritropoietin merupakan hormone glikoprotein yang diproduksi oleh ginjal untuk meningkatkan eritropoiesis di sumsum tulang. Implikasi terapeutik EPO telah lama dikenal untuk penyakit anemia khususnya pada pasien anemia dengan Gagal Ginjal Kronis (GGK). Tingkat keberhasilan terapi menggunakan EPO mencapai 55,55% pada pasien GGK yang rutin menjalani hemodialisis. Akan tetapi, EPO tidak hanya berperan dalam GGK, EPO juga memberikan efek angiogenik, kardioprotektif, dan neuroprotektif. Review literatur ini bertujuan untuk memberikan pemahaman lebih lanjut mengenai potensi terapeutik EPO selain anemia pada GGK. Review ini menggunakan jurnal yang diterbitkan paling maksimal 10 tahun terakhir melalui fitur pencarian pada google.com, google scholar, ncbi, PubMed, MEDLINE. Pencarian sumber data dilakukan dengan menggunakan kata kunci “Eritropoietin”, “implikasi”, “terapeutik”,”Erythropoietin”, “implications”, “clinical”, therapeutic. Jurnal yang sesuai dengan keyword pencarian selanjutnya dilakukan analisis dan identifikasi sesuai dengan luaran literatur yang akan di inklusi. Dari 15 peneliti, dapat disimpulkan bahwa EPO tidak hanya berfungsi dalam hematopoiesis, tetapi juga memiliki efek non-hematopoietik seperti angiogenik, kardioprotektif, dan neuroprotektif. EPO menunjukkan potensi dalam terapi berbagai kondisi medis, termasuk trauma otak, penyakit neurodegeneratif (Parkinson dan Alzheimer), fraktur tulang, bronkopulmoner displasia (BPD) pada bayi prematur, serta infark miokard. Efek terapeutik non-hematopoietik EPO melibatkan perbaikan kerusakan jaringan, mengurangi sitokin inflamasi dalam tubuh, memberikan efek neurogenerasi yang baik pada system saraf pusat maupun system saraf perifer, dan peningkatan regenerasi sel-sel penting.References
Barbieri, M., Chiodini, P., Di Gennaro, P., Hafez, G., Liabeuf, S., Malyszko, J., Mani, L. Y., Raso, F. M., Pepin, M., Perico, N., Simeoni, M., Zoccali, C., Tortorella, G., Capuano, A., Remuzzi, G., Capasso, G., & Paolisso, G. (2024). Efficacy of erythropoietin as a neuroprotective agent in CKD-associated cognitive dysfunction: A literature systematic review. Pharmacological Research, 203(107146). https://doi.org/10.1016/j.phrs.2024.107146.
Bernado, P., Rahardjo, & Rahajoe, P. S. (2016). Pengaruh Recombinant Human Erythropeoitin terhadap jumlah Osteoblast, Osteoklas dan kadar hemoglbin apda penyembuhan fraktur tulang mandibula. Journal Ked Gi Univ Gajah Mada, 7(2), 131–137.
Budiman, B., Sihombing, R., & Pradina, P. (2017). Hubungan Dislipidemia, Hipertensi Dan Diabetes Melitus Dengan Kejadian Infark Miokard Akut. Jurnal Kesehatan Masyarakat Andalas, 10(1), 32–37. https://doi.org/10.24893/jkma.v10i1.160.
Bui, K. C. T., Kim, R., Abbasi, A., Nguyen, M., Villosis, M. F., & Chen, Q. (2019). Erythropoietin treatment is associated with a reduction in moderate to severe bronchopulmonary dysplasia in preterm infants. A regional retrospective study. Early Human Development, 137(March), 104831. https://doi.org/10.1016/j.earlhumdev.2019.104831.
Cevik, B., Solmaz, V., Yigitturk, G., Cavuso?lu, T., Peker, G., & Erbas, O. (2017). Neuroprotective effects of erythropoietin on Alzheimer’s dementia model in rats. Advances in Clinical and Experimental Medicine, 26(1), 23–29. https://doi.org/10.17219/acem/61044.
Chuncharunee, S., Kanitsap, N., Suwanban, T., Khuhapinant, A., Uaprasert, N., Chansung, K., Rattarittamrong, E., Wongkhantee, S., Siritanaratanakul, N., Norasetthada, L., Na Nakorn, T., & Charnwiboonsri, C. (2016). A Prospective Multicenter Open-Label Study of the Effectiveness of Epoetin Beta for Patients with Low/Intermediate-1-Risk Myelodysplastic Syndrome (MDS): A Preliminary Result. Blood, 128(22), 5543–5543. https://doi.org/10.1182/blood.v128.22.5543.5543.
Coulibaly, A. P., & Provencio, J. J. (2020). Aneurysmal Subarachnoid Hemorrhage: an Overview of Inflammation-Induced Cellular Changes. Neurotherapeutics, 17(2), 436–445. https://doi.org/10.1007/s13311-019-00829-x.
Carvalho, L. A., Fleming, R., Sant’Anna, M., Guimarães, R., Dantas, A. M., Morizot-Leite, E., Cavalcante, L. A., & Allodi, S. (2018). Neuroprotective effects of erythropoietin on rat retinas subjected to oligemia. Clinics, 73, 1–5. https://doi.org/10.6061/clinics/2018/e161.
Dhinata, K. S., Nababan, G. T., & Pratama, D. C. (2018). Pemanfaatan Eritropoietin sebagai Neuroprotektan Terhadap Kerusakan Sistem Saraf Pusat Neonatus Akibat Infeksi Varisela Kongenital. Jurnal Ilmiah Mahasiswa Kedokteran Indonesia, 6(2), 4–12.
Erba?, O., Çiar, B. P., Solmaz, V., Çavu?o?lu, T., & Ate?, U. (2015). The neuroprotective effect of erythropoietin on experimental Parkinson model in rats. Neuropeptides, 49, 1–5. https://doi.org/10.1016/j.npep.2014.10.003.
Faradilla, T., Hadi, N., & Syiah Kuala, U. (2024). IJM: Indonesian Journal of Multidisciplinary Asuhan Keperawatan pada Lansia dengan Gout Arthritis dan Hiperkolesterolemia di Kota Banda Aceh. IJM: Indonesian Journal of Multidisciplinary, 2(6), 175–183. https://journal.csspublishing/index.php/ijm
.Grasso, G., Tomasello, G., Noto, M., Alafaci, C., & Cappello, F. (2015). Erythropoietin for the treatment of subarachnoid hemorrhage: A feasible ingredient for a successful medical recipe. Molecular Medicine, 21, 979–987. https://doi.org/10.2119/molmed.2015.00177.
Hoeber, D., Sifringer, M., Van De Looij, Y., Herz, J., Sizonenko, S. V., Kempe, K., Serdar, M., Palasz, J., Hadamitzky, M., Endesfelder, S., Fandrey, J., Felderhoff-Müser, U., & Bendix, I. (2016). Erythropoietin Restores Long-Term Neurocognitive Function Involving Mechanisms of Neuronal Plasticity in a Model of Hyperoxia-Induced Preterm Brain Injury. Oxidative Medicine and Cellular Longevity, 1–13. https://doi.org/10.1155/2016/9247493.
Nichol, A., French, C., Little, L., Presneill, J., Cooper, D. J., Haddad, S., Duranteau, J., Huet, O., Skrifvars, M., Arabi, Y., & Bellomo, R. (2015). Erythropoietin in traumatic brain injury: Study protocol for a randomised controlled trial. Trials, 16(1), 1–10. https://doi.org/10.1186/s13063-014-0528-6.
Park, S., Greenberg, P., Yucel, A., Farmer, C., O’Neill, F., Brandao, C. O., & Fenaux, P. (2018). Clinical effectiveness and safety of erythropoietin-stimulating agents for the treatment of low- and intermediate-1risk myelodysplastic syndrome_ a systematic literature review. British Journal of Haematology, 1–27. doi: 10.1111/bjh.15707.
Prasad, T. H., Swamy, A. G. N., Senthilkumar, S., Surendra, B. V., & Vijayaraghavan, R. (2024). Therapeutic Evaluation of Recombinant Human Erythropoietin (rhEPO) In Isoproterenol Induced Myocardial Infarction in Wistar Rats. Journal of Applied Bioanalysis, 10(2), 164–180. https://doi.org/10.53555/jab.v10i2.169.
Prenggono, M. D. (2015). Eritropoetin dan Penggunaan Eritropoetin pada Pasien Kanker dengan Anemia. Cdk, 42(1), 20–28.
Resende, A. P., Rosolen, S. G., Nunes, T., São Braz, B., & Delgado, E. (2018). Functional and Structural Effects of Erythropoietin Subconjunctival Administration in Glaucomatous Animals. Biomedicine Hub, 3(2), 1–11. https://doi.org/10.1159/000488970.
Suryanty, R., Rosdiana, N., & Lubis, B. (2016). Peran Eritropoietin pada Anemia Akibat Keganasan pada Anak. Sari Pediatri, 7(1), 34. https://doi.org/10.14238/sp7.1.2005.34-8.
Ugurluer, G., Cebi, A., Mert, H., Mert, N., Serin, M., & Erkal, H. S. (2016). Neuroprotective effects of erythropoietin against oxidant injury following brain irradiation: An experimental study. Archives of Medical Science, 12(6), 1348–1353. https://doi.org/10.5114/aoms.2016.58622.
Voelker, R. (2023). What Is Glaucoma? Jama, 330(16), 1594. https://doi.org/10.1001/jama.2023.16311.
Wahyunita, S., & Kurniawan, G. (2023). Pengaruh Eritropoetin Terhadap Tingkat Keberhasilan Terapi Anemia Pada Pasien Anemia Pada Pasien Chronic Kidney Disease Di Rsud Ulin Banjarmasin. Jurnal Insan Farmasi Indonesia, 6(3), 121–126. https://doi.org/10.36387/jifi.v6i3.1690.
Wu, Y. W., Comstock, B. A., Gonzalez, F. F., Mayock, D. E., Goodman, A. M., Maitre, N. L., Chang, T., Van Meurs, K. P., Lampland, A. L., Bendel-Stenzel, E., Mathur, A. M., Wu, T.-W., Riley, D., Mietzsch, U., Chalak, L., Flibotte, J., Weitkamp, J.-H., Ahmad, K. A., Yanowitz, T. D., … Juul, S. E. (2022). Trial of Erythropoietin for Hypoxic–Ischemic Encephalopathy in Newborns. New England Journal of Medicine, 387(2), 148–159. https://doi.org/10.1056/nejmoa2119660.
Zhang, Y., Wang, L., Dey, S., Alnaeeli, M., Suresh, S., Rogers, H., Teng, R., & Noguchi, C. T. (2014). Erythropoietin action in stress response, tissue maintenance and metabolism. International Journal of Molecular Sciences, 15(6), 10296–10333. https://doi.org/10.3390/ijms150610296.
Zhou, Z. W., Li, F., Zheng, Z. T., Li, Y. D., Chen, T. H., Gao, W. W., Chen, J. L., & Zhang, J. N. (2017). Erythropoietin regulates immune/inflammatory reaction and improves neurological function outcomes in traumatic brain injury. Brain and Behavior, 7(11), 1–10. https://doi.org/10.1002/brb3.827.
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