PENGARUH VITAMIN D DALAM MENURUNKAN RISIKO PRE-EKLAMSIA: SYSTEMATIC LITERATUR REVIEW
DOI:
https://doi.org/10.31004/jkt.v5i4.38077Keywords:
Defisiensi, Vitamin D, PreeklamsiaAbstract
Preeklamsia merupakan salah satu penyebab utama morbiditas dan mortalitas ibu dan janin di seluruh dunia. Secara global, prevalensi wanita hamil yang mengalami preeklamsia sebesar 4,6%. Defisiensi vitamin D selama kehamilan telah dikaitkan dengan sejumlah masalah kesehatan. Beberapa penelitian melaporkan suplementasi vitamin D dapat menurunkan risiko preeklamsia. Prevalensi defisiensi Vitamin D pada wanita hamil berkisar 26%- 98% di berbagai negara di seluruh dunia. Pencarian literatur menggunakan 3 database yang terdiri dari Pubmed, Spinger, dan Proquest. Dalam melakukan pencarian, kami menggunakan kata kunci “Vitamin D” atau “Cholecalciferol” atau “Hydroxycholecalciferols atau “Ergocalciferols” dan Pre Eclampsia” atau “Preeclampsia” atau “Pregnancy Toxemias”. Hasil analisis artikel didapatkan 8 dari 768 artikel yang memenuhi syarat. Enam dari studi menunjukkan suplementasi vitamin D dapat menurunkan risiko preeklamsia secara signifikan. Sedangkan dua dari studi tidak menunjukkan perbedaan yang signifikan. Perbedaan dalam hasil mungkin disebabkan oleh variasi dosis vitamin D, waktu suplementasi, kadar vitamin D awal, dan faktor khusus studi lainnya. Penelitian lebih lanjut diperlukan untuk menentukan dosis dan waktu optimal pemberian suplemen vitamin D. Kata kunci : Defisiensi, Vitamin D, PreeklamsiaReferences
ACOG Practice Bulletin No. 202: Gestational Hypertension and Preeclampsia. (2019). Obstetrics and Gynecology, 133(1), e1–e25. https://doi.org/10.1097/AOG.0000000000003018
Ali, A. M., Alobaid, A., Malhis, T. N., & Khattab, A. F. (2019a). Effect of vitamin D3 supplementation in pregnancy on risk of pre-eclampsia - Randomized controlled trial. Clinical Nutrition (Edinburgh, Scotland), 38(2), 557–563. https://doi.org/10.1016/J.CLNU.2018.02.023
Ali, A. M., Alobaid, A., Malhis, T. N., & Khattab, A. F. (2019b). Effect of vitamin D3 supplementation in pregnancy on risk of pre-eclampsia - Randomized controlled trial. Clinical Nutrition (Edinburgh, Scotland), 38(2), 557–563. https://doi.org/10.1016/J.CLNU.2018.02.023
AlSubai, A., Baqai, M. H., Agha, H., Shankarlal, N., Javaid, S. S., Jesrani, E. K., Golani, S., Akram, A., Qureshi, F., Ahmed, S., & Saran, S. (2023). Vitamin D and preeclampsia: A systematic review and meta-analysis. SAGE Open Medicine, 11, 20503121231212092. https://doi.org/10.1177/20503121231212093
Behjat Sasan, S., Zandvakili, F., Soufizadeh, N., & Baybordi, E. (2017). The Effects of Vitamin D Supplement on Prevention of Recurrence of Preeclampsia in Pregnant Women with a History of Preeclampsia. Obstetrics and Gynecology International, 2017, 8249264. https://doi.org/10.1155/2017/8249264
Bodnar, L. M., Simhan, H. N., Powers, R. W., Frank, M. P., Cooperstein, E., & Roberts, J. M. (2007). High prevalence of vitamin D insufficiency in black and white pregnant women residing in the northern United States and their neonates. The Journal of Nutrition, 137(2), 447–452. https://doi.org/10.1093/JN/137.2.447
Dahma, G., Neamtu, R., Nitu, R., Gluhovschi, A., Bratosin, F., Grigoras, M. L., Silaghi, C., Citu, C., Orlu, I. N., Bhattarai, S., Mocanu, A. G., Craina, M., & Bernad, E. (2022). The Influence of Maternal Vitamin D Supplementation in Pregnancies Associated with Preeclampsia: A Case-Control Study. Nutrients, 14(15), 3008. https://doi.org/10.3390/NU14153008
Holick, M. F. (2006). Resurrection of vitamin D deficiency and rickets. The Journal of Clinical Investigation, 116(8), 2062–2072. https://doi.org/10.1172/JCI29449
IOM. (2011). Dietary Reference Intakes for Calcium and Vitamin D. National Academy Press.
Jeong, H. Y., Park, K. M., Lee, M. J., Yang, D. H., Kim, S. H., & Lee, S. Y. (2017). Vitamin D and Hypertension. Electrolytes & Blood Pressure?: E & BP, 15(1), 1. https://doi.org/10.5049/EBP.2017.15.1.1
Khaing, W., Vallibhakara, S. A. O., Tantrakul, V., Vallibhakara, O., Rattanasiri, S., McEvoy, M., Attia, J., & Thakkinstian, A. (2017). Calcium and Vitamin D Supplementation for Prevention of Preeclampsia: A Systematic Review and Network Meta-Analysis. Nutrients, 9(10). https://doi.org/10.3390/NU9101141
Mirzakhani, H., Litonjua, A. A., McElrath, T. F., O’Connor, G., Lee-Parritz, A., Iverson, R., MacOnes, G., Strunk, R. C., Bacharier, L. B., Zeiger, R., Hollis, B. W., Handy, D. E., Sharma, A., Laranjo, N., Carey, V., Qiu, W., Santolini, M., Liu, S., Chhabra, D., … Weiss, S. T. (2016). Early pregnancy vitamin D status and risk of preeclampsia. The Journal of Clinical Investigation, 126(12), 4702. https://doi.org/10.1172/JCI89031
Møller, U. K., Streym, S., Mosekilde, L., Heickendorff, L., Flyvbjerg, A., Frystyk, J., Jensen, L. T., & Rejnmark, L. (2013). Changes in calcitropic hormones, bone markers and insulin-like growth factor I (IGF-I) during pregnancy and postpartum: a controlled cohort study. Osteoporosis International?: A Journal Established as Result of Cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 24(4), 1307–1320. https://doi.org/10.1007/S00198-012-2062-2
Naghshineh, E., & Sheikhaliyan, S. (2016a). Effect of vitamin D supplementation in the reduce risk of preeclampsia in nulliparous women. Advanced Biomedical Research, 5(1), 7. https://doi.org/10.4103/2277-9175.175239
Naghshineh, E., & Sheikhaliyan, S. (2016b). Effect of vitamin D supplementation in the reduce risk of preeclampsia in nulliparous women. Advanced Biomedical Research, 5(1), 7. https://doi.org/10.4103/2277-9175.175239
Palacios, C., Kostiuk, L. K., & Peña-Rosas, J. P. (2019). Vitamin D supplementation for women during pregnancy. The Cochrane Database of Systematic Reviews, 2019(7), CD008873. https://doi.org/10.1002/14651858.CD008873.PUB4
Peraçoli, J. C., Borges, V. T. M., Ramos, J. G. L., de Carvalho Cavalli, R., de Almeida Martins Costa, S. H., de Oliveira, L. G., de Souza, F. L. P., Korkes, H. A., Brum, I. R., do Nascimento, M. L. C., Junior, M. D. C., Sass, N., Diniz, A. L. D., da Cunha Filho, E. V., & de Campos Prado, C. A. (2019). Pre-eclampsia/Eclampsia. Revista Brasileira de Ginecologia e Obstetricia?: Revista Da Federacao Brasileira Das Sociedades de Ginecologia e Obstetricia, 41(5), 318–332. https://doi.org/10.1055/S-0039-1687859
Pilz, S., Zittermann, A., Obeid, R., Hahn, A., Pludowski, P., Trummer, C., Lerchbaum, E., Pérez-López, F. R., Karras, S. N., & März, W. (2018). The Role of Vitamin D in Fertility and during Pregnancy and Lactation: A Review of Clinical Data. International Journal of Environmental Research and Public Health, 15(10). https://doi.org/10.3390/IJERPH15102241
Poon, L. C., Shennan, A., Hyett, J. A., Kapur, A., Hadar, E., Divakar, H., McAuliffe, F., da Silva Costa, F., von Dadelszen, P., McIntyre, H. D., Kihara, A. B., Di Renzo, G. C., Romero, R., D’Alton, M., Berghella, V., Nicolaides, K. H., & Hod, M. (2019). The International Federation of Gynecology and Obstetrics (FIGO) Initiative on Preeclampsia (PE): A Pragmatic Guide for First Trimester Screening and Prevention. International Journal of Gynaecology and Obstetrics: The Official Organ of the International Federation of Gynaecology and Obstetrics, 145(Suppl 1), 1. https://doi.org/10.1002/IJGO.12802
Qian, L., Wang, H., Wu, F., Li, M., Chen, W., & Lv, L. (2015). Vitamin D3 alters Toll-like receptor 4 signaling in monocytes of pregnant women at risk for preeclampsia. International Journal of Clinical and Experimental Medicine, 8(10), 18041. https://pmc.ncbi.nlm.nih.gov/articles/PMC4694299/
RCOG. (2014). Vitamin D in Pregnancy (Vol. 43). Royal College of Obstetricians and Gynaecologists.
Rolnik, D. L., Nicolaides, K. H., & Poon, L. C. (2022). Prevention of preeclampsia with aspirin. American Journal of Obstetrics and Gynecology, 226(2), S1108–S1119. https://doi.org/10.1016/J.AJOG.2020.08.045/ATTACHMENT/20B4BA05-DEFE-4FDD-8C9C-5A473DBA254E/MMC1.PPTX
Rostami, M., Tehrani, F. R., Simbar, M., Yarandi, R. B., Minooee, S., Hollis, B. W., & Hosseinpanah, F. (2018). Effectiveness of Prenatal Vitamin D Deficiency Screening and Treatment Program: A Stratified Randomized Field Trial. The Journal of Clinical Endocrinology & Metabolism, 103(8), 2936–2948. https://doi.org/10.1210/JC.2018-00109
Schulz, E. V., Cruze, L., Wei, W., Gehris, J., & Wagner, C. L. (2017). Maternal vitamin D sufficiency and reduced placental gene expression in angiogenic biomarkers related to comorbidities of pregnancy. The Journal of Steroid Biochemistry and Molecular Biology, 173, 273–279. https://doi.org/10.1016/J.JSBMB.2017.02.003
Tranquilli, A. L., Dekker, G., Magee, L., Roberts, J., Sibai, B. M., Steyn, W., Zeeman, G. G., & Brown, M. A. (2014). The classification, diagnosis and management of the hypertensive disorders of pregnancy: A revised statement from the ISSHP. Pregnancy Hypertension, 4(2), 97–104. https://doi.org/10.1016/J.PREGHY.2014.02.001
Xiaomang, J., & Yanling, W. (2020). Effect of vitamin D3 supplementation during pregnancy on high risk factors - a randomized controlled trial. Journal of Perinatal Medicine, 49(4), 480–484. https://doi.org/10.1515/JPM-2020-0318
Xiaomang, J., & Yanling, W. (2021). Effect of vitamin D3 supplementation during pregnancy on high risk factors - A randomized controlled trial. Journal of Perinatal Medicine, 49(4), 480–484. https://doi.org/10.1515/JPM-2020-0318/MACHINEREADABLECITATION/RIS
Zhang, H., Wang, S., Tuo, L., Zhai, Q., Cui, J., Chen, D., & Xu, D. (2022). Relationship between Maternal Vitamin D Levels and Adverse Outcomes. Nutrients, 14(20). https://doi.org/10.3390/NU14204230
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