PROTON PUMP INHIBITOR SEBAGAI PROFILAKSIS STRESS ULCER PADA PASIEN BEDAH DIGESTIF DI RSUD R.T.NOTOPURO SIDOARJO
DOI:
https://doi.org/10.31004/jkt.v5i4.37878Keywords:
Bedah Digestif, Profilaksis Stress Ulcer, Proton Pump InhibitorAbstract
Profilaksis stress ulcer diberikan pada pasien dengan kondisi kritis atau pada pasien pembedahan untuk mencegah perdarahan. Profilaksis stress ulcer yang digunakan salah satunya obat golongan Proton Pump Inhibitor (PPI). Tujuan pada penelitian ini adalah mengetahui pola penggunaan obat PPI sebagai profilaksis stress ulcer meliputi jenis obat, dosis obat dan lama pemberian. Metode penelitian dilakukan secara observasional dengan pengambilan data rekam medik retrospektif dari bulan Januari 2018 – Desember 2023 dan dianalisis secara deskriptif, di dapat 32 pasien memenuhi kriteria inklusi. Hasil penelitian jenis obat yang digunakan sebagai profilaksis stress ulcer pada pasien bedah digestif adalah monoterapi dengan obat omeprazole pada 28 pasien dan kombinasi berupa omeprazole dengan ranitidine pada 2 pasien. Dosis penggunaan profilaksis stress ulcer pasien bedah digestif yaitu omeprazole 2x40 mg/ml dan esomeprazole 1x40mg/ml. Lama pemberian profilaksis stress ulcer pada pasien bedah digestif adalah kurang lebih 7 hari dan dapat dilanjutkan dalam dosis terapi. Dari penelitian ini disimpulkan pemberian profilaksis stress ulcer pada pasien bedah digestif berdasarkan jenis, dosis dan lama pemberian sudah sesuai.References
Guillamondegui, O. D., Gunter, O. L., Bonadies, J. A., Kurek, S. J., Moya, M. A. D., & Sing, R. F. (2008). Practice Management Guidelines For Stress Ulcer Prophylaxis. Eastern Association for the Surgery of Trauma
Horsa, B.A., Ayele, Y. and Ayalew, M.B. 2019 ‘Assessment of pharmacologic prophylaxis use against stress ulcer in the medical wards of University of Gondar Hospital’, SAGE Open Medicine, 7, p. 205031211982740. Available at: https://doi.org/10.1177/2050312119827409.
Kemenkes RI 2021 ‘FORNAS Keputusan Mentri Kesehatan Republik Indonesia Nomor HK.01.07/ Menkes / 659/ 2021 Tentang Formularium Nasional’. Available At: Http://Pionas.Pom.Go.Id/Ioni/Bab-1-Sistem-Saluran-Cerna0/13- Antitukak/134-Penghambat-Pompa-Proton.Krag, M. et al. 2015 ‘Stress Ulcer Prophylaxis In The Intensive Care Unit: An International Survey Of 97 Units In 11 Countries: Stress Ulcer Prophylaxis In The ICU’, Acta Anaesthesiologica Scandinavica, 59(5), Pp. 576–585. Available At: https://doi.org/10.1111/aas.12508.
Khosravizadeh, O., Vatankhah, S., Bastani, P., Kalhor, R., Alirezaei, S., & Doosty, F. (2016). Factors affecting length of stay in teaching hospitals of a middle-income country. Electronic Physician, 8(10), 3042–3047. https://doi.org/10.19082/3042
Mahdayana, Indira Dayang et al. 2020 ‘Studi Penggunaan Stress Ulcer PadaPasien Bedah Digestif Di RSUD Dr.Soetomo Surabaya’. Universitas Airlangga Surabaya5(2), DOI: https://doi.org/10.21776/ub.pji.2020.005.02.1
Miškulin, M., Lali?, Z., Dumi?, A., Miškulin, I., Mati?, M., & Pavlovi?, N. (2018). New Topical Treatment of Symptomatic Internal Haemorrhoids in a General Practice Setting. Journal of Health Sciences, 8(3), 148–153. https://doi.org/10.17532/jhsci.2018.454
Mo, C. et al. 2015 ‘PPI versus Histamine H2 Receptor Antagonists for Prevention of Upper Gastrointestinal Injury Associated with Low-Dose Aspirin: Systematic Review and Meta-analysis’, PLOS ONE. Edited by J. Green, 10(7), p. e0131558. Available at: https://doi.org/10.1371/journal.pone.0131558
Plummer, M.P., Blaser, A. and Deane, A.M. 2014 ‘Stress Ulceration: Prevalence, Pathology And Association With Adverse Outcomes’, Critical Care, 18(2), P. 213. Available at: https://doi.org/10.1186/cc13780.
Rafinazari, N. et al. 2016 ‘Adherence To Stress-Related Mucosal Damage Prophylaxis Guideline In Patients Admitted To The Intensive Care Unit’, Journal Of Research In Pharmacy Practice, 5(3), P. 186. Available at: https://doi.org/10.4103/2279-042x.185728.
Santos, Y.D.A.P.D. et al. 2019 ‘Adherence to a stress ulcer prophylaxis protocol by critically ill patients: a prospective cohort study’, Revista Brasileira de Terapia Intensiva, 32(1). Available at: https://doi.org/10.5935/0103- 507X.20200007
Shin, J.M. and Kim, N. 2013 ‘Pharmacokinetics And Pharmacodynamics Of The Proton Pump nhibitors’, Journal Of Neurogastroenterology And Motility, 19(1), Pp. 25–35. Available at: https://doi.org/10.5056/jnm.2013.19.1.25.
Stinton, L. M., & Shaffer, E. A. (2012). Epidemiology of Gallbladder Disease: Cholelithiasis and Cancer. Gut and Liver, 6(2), 172–187. https://doi.org/10.5009/gnl.2012.6.2.172
Tham TCK, Collins JS., Soetikno R .(2016). Gastrointestinal Emergencies Third Edition. Third Edit. Blackwell Publishing; 2016. 276–277 p. Available at: https://doi.org/10.4103/0971-5916.224938
Yuda Handaya, Adeodatus.2017 ‘ Deteksi Dini & Atasi 31 Penyakit Bedah Saluran Cerna (Digestif)’, Yogyakarta: Rapha Publishing.
Downloads
Published
Issue
Section
License
Copyright (c) 2024 Endang Tri Arsita Setyani, Asri Wido Mukti, Ira Purbosari
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work’s authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal’s published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
