PERBEDAAN EFEKTIFITAS VARIAN DOSIS DARI PEMBERIAN EKSTRAK DAUN KELOR TERHADAP PENURUNAN INTENSITAS DISMENOREA PRIMER

Authors

  • Kaifar Nuha Akademi Kebidanan Saleha
  • Cut Efriana Akademi Kebidanan Saleha
  • Shella Kamal Akademi Kebidanan Saleha

DOI:

https://doi.org/10.31004/jkt.v5i4.35447

Keywords:

dismenorea, nyeri menstruasi, daun kelor, moringa oleifera, intensitas nyeri

Abstract

Dismenorea primer merupakan kondisi umum yang dialami oleh remaja perempuan, yang menyebabkan ketidaknyamanan signifikan serta mengganggu aktivitas sehari-hari. Ekstrak Moringa oleifera yang dikenal memiliki sifat antiinflamasi dan analgesik, telah dieksplorasi sebagai pengobatan potensial untuk mengurangi nyeri dismenorea. Penelitian ini bertujuan untuk mengevaluasi efektivitas tiga takaran berbeda pada ekstrak Moringa oleifera (500 mg, 1000 mg, dan 1500 mg) dalam menurunkan intensitas nyeri dismenorea primer. Penelitian kuantitatif ini dilakukan dengan melibatkan 80 partisipan dari SMA Negeri 7 Banda Aceh. Intensitas nyeri diukur menggunakan Numeric Rating Scale (NRS) 2 jam setelah intervensi. Hasil penelitian menunjukkan bahwa ketiga dosis tersebut efektif dalam menurunkan intensitas nyeri dengan nilai p < 0,05. Selain itu, dosis 1500 mg ditemukan paling efektif dibandingkan dengan kelompok lainnya dalam mengurangi nyeri dismenorea. Temuan ini memberikan kontribusi terhadap pemahaman mengenai potensi ekstrak Moringa oleifera sebagai opsi pengobatan alternatif untuk dismenorea primer.

References

AB, Y., AA, T., & AA, A. (2022). Formulation and Evaluation of Mango Leaf Tea Supplemented with Moringa and Ginger Powder. Haya: The Saudi Journal of Life Sciences, 7(5). https://doi.org/10.36348/sjls.2022.v07i05.002

Atikah, P., & Siti, M. (2011). Menarche: Mentruasi Pertama Penuh Makna. Nuha Medika.

Azlan, U. K., Mediani, A., Rohani, E. R., Tong, X., Han, R., Misnan, N. M., Jam, F. A., Bunawan, H., Sarian, M. N., & Hamezah, H. S. (2022). A Comprehensive Review with Updated Future Perspectives on the Ethnomedicinal and Pharmacological Aspects of Moringa oleifera. In Molecules (Vol. 27, Issue 18). https://doi.org/10.3390/molecules27185765

Barcikowska, Z., Rajkowska-Labon, E., Grzybowska, M. E., Hansdorfer-Korzon, R., & Zorena, K. (2020). Inflammatory markers in dysmenorrhea and therapeutic options. In International Journal of Environmental Research and Public Health (Vol. 17, Issue 4). https://doi.org/10.3390/ijerph17041191

de Arruda, G. T., Driusso, P., Rodrigues, J. C., de Godoy, A. G., & Avila, M. A. (2022). Numerical rating scale for dysmenorrhea-related pain: a clinimetric study. Gynecological Endocrinology, 38(8). https://doi.org/10.1080/09513590.2022.2099831

Elston, R. C. (2015). Fundamentals of Biostatistics. In The American Journal of Tropical Medicine and Hygiene (Vol. 18, Issue 3). https://doi.org/10.4269/ajtmh.1969.18.479

Fard, M., Arulselvan, P., Karthivashan, G., Adam, S., & Fakurazi, S. (2015). Bioactive extract from moringa oleifera inhibits the pro-inflammatory mediators in lipopolysaccharide stimulated macrophages. Pharmacognosy Magazine, 11(44). https://doi.org/10.4103/0973-1296.172961

Febriansyah, E., Nuha, K., & Kamal, S. (2021). PENGARUH COKELAT HITAM TERHADAP INTENSITAS NYERI DISMENORE PRIMER PADA MAHASISWI AKADEMI KEBIDANAN SALEHA BANDA ACEH. Sel Jurnal Penelitian Kesehatan, 8(2). https://doi.org/10.22435/sel.v8i2.5108

Fernández-Martínez, E., Dolores Onieva-Zafra, M., & Parra-Fernández, M. L. (2019). The Impact of Dysmenorrhea on Quality of Life among Spanish Female University Students. https://doi.org/10.3390/ijerph16050713

Fernández-Martínez, E., Onieva-Zafra, M. D., Abreu-Sánchez, A., Fernández-Muñóz, J. J., & Parra-Fernández, M. L. (2020). Absenteeism during menstruation among nursing students in Spain. International Journal of Environmental Research and Public Health, 17(1), 1–12. https://doi.org/10.3390/ijerph17010053

Gomathy, N., Dhanasekar, K. R., & Trayambak, D. (2019). An effective but forgotten therapy in dysmenorrhea. Journal of SAFOG, 11(3), 203–206. https://doi.org/10.5005/jp-journals-10006-1683

Hawker, G. A., Mian, S., Kendzerska, T., & French, M. (2011). Measures of adult pain: Visual Analog Scale for Pain (VAS Pain), Numeric Rating Scale for Pain (NRS Pain), McGill Pain Questionnaire (MPQ), Short-Form McGill Pain Questionnaire (SF-MPQ), Chronic Pain Grade Scale (CPGS), Short Form-36 Bodily Pain Scale (SF-36 BPS), and Measure of Intermittent and Constant Osteoarthritis Pain (ICOAP). Arthritis Care and Research, 63(SUPPL. 11). https://doi.org/10.1002/acr.20543

Iacovides, S., Avidon, I., & Baker, F. C. (2015). What we know about primary dysmenorrhea today: A critical review. Human Reproduction Update, 21(6). https://doi.org/10.1093/humupd/dmv039

Itani, R., Soubra, L., Karout, S., Rahme, D., Karout, L., & Khojah, H. M. J. (2022). Primary Dysmenorrhea: Pathophysiology, Diagnosis, and Treatment Updates. In Korean Journal of Family Medicine (Vol. 43, Issue 2). https://doi.org/10.4082/kjfm.21.0103

McCormack, H. M., Horne, D. J. de L., & Sheather, S. (1988). Clinical applications of visual analogue scales: A critical review. Psychological Medicine, 18(4). https://doi.org/10.1017/S0033291700009934

Mendiratta, V., & Lentz, G. M. (2021). Primary and secondary dysmenorrhea, premenstrual syndrome, and premenstrual dysphoric disorder: Etiology, Diagnosis, Management. In Comprehensive Gynecology. https://doi.org/10.1016/B978-0-323-65399-2.00044-9

Ningsih, R., Setyowati, & Rahmah. (2013). Efektivitas Paket Pereda Nyeri Pada Remaja Dengan Dismenore. Journal Keperawatan Indonesia, 67–76.

Nuha, K., Rusmil, K., Ganiem, A. R., Permadi, W., & Diah Herawati, D. M. (2023). Single-Blind Randomized Controlled Trial: Comparative Efficacy of Dark Chocolate, Coconut Water, and Ibuprofen in Managing Primary Dysmenorrhea. International Journal of Environmental Research and Public Health, 20(16). https://doi.org/10.3390/ijerph20166619

Nurohmah, N., Hannifah, F., & Sugesti, R. (2024). Effectiveness Of Moringa Oleifera And Ginger Extract On The Intensity Of Dysmenorrhea In Adolescent Girls. Care?: Jurnal Ilmiah Ilmu Kesehatan, 12(2), 347–352. https://doi.org/10.33366/jc.v12i2.5955

Pachiappan, S., Saravanan, P. P., Mani, J., Chidambaram, J., Madeshwaran, M., & Vetriselvan, O. (2022). Effect of Moringa oleifera soup on primary dysmenorrhea in adolescent girls. International Journal of Research in Medical Sciences, 10(6). https://doi.org/10.18203/2320-6012.ijrms20221489

Panangi, A. N., & La Sakka. (2022). Pelatihan Pembuatan Simplisia Daun Kelor (Morinaga Oliefera) Pada Masyarakat Desa Mangeloreng Kecamatan Bantimurung, Kabupaten Maros. Jurnal Pengabdian Farmasi Dan Sains, 1(1). https://doi.org/10.22487/jpsf.2022.v1.i1.16128

Pareek, A., Pant, M., Gupta, M. M., Kashania, P., Ratan, Y., Jain, V., Pareek, A., & Chuturgoon, A. A. (2023). Moringa oleifera: An Updated Comprehensive Review of Its Pharmacological Activities, Ethnomedicinal, Phytopharmaceutical Formulation, Clinical, Phytochemical, and Toxicological Aspects. In International Journal of Molecular Sciences (Vol. 24, Issue 3). https://doi.org/10.3390/ijms24032098

Petraglia, F., Bernardi, M., Lazzeri, L., Perelli, F., & Reis, F. M. (2017). Dysmenorrhea and related disorders. In F1000Research (Vol. 6). https://doi.org/10.12688/f1000research.11682.1

Rini Handayani, Nurmalia Zakaria, Erliana Winingsih, Fauziah, Yuni Dewi Safrida, & Rizki Andalia. (2022). Antioxidant Activity of Polyherbal Syrup Extracted by the Boiling and Decoction Methods. International Journal of Scientific Research and Engineering Development, 5(5), 71–715.

Saxena, S. (2024). Formulation And Evaluation Of Moringa Oleifera Leaves Powder Soup For Dysmenorrhea. Int. J. of Pharm. Sci, 2(7), 816. https://doi.org/10.5281/zenodo.12736962

Siswanto. (2012). Sekilas tentang Randomized Controlled Trial (RCT). Warta LPM, 3(1), 1–3. http://journals.ums.ac.id/index.php/warta/article/view/13429

Srivastava, S., Pandey, V. K., Dash, K. K., Dayal, D., Wal, P., Debnath, B., Singh, R., & Dar, A. H. (2023). Dynamic bioactive properties of nutritional superfood Moringa oleifera: A comprehensive review. Journal of Agriculture and Food Research, 14. https://doi.org/10.1016/j.jafr.2023.100860

Stoelting, W., & Gettelfinger. (2009). A Case Study and Comprehensive differential diagnosis and care plan for the three Ds of women’s health: Primary dysmenorrheal, secondary dysmenorrheal, and dyspareunia. Indiana University.

Sultana, S. (2020). Nutritional and functional properties of Moringa oleifera. Metabolism Open, 8. https://doi.org/10.1016/j.metop.2020.100061

Wanjiru, J., Gathirwa, J., Sauli, E., & Swai, H. S. (2022). Formulation, Optimization, and Evaluation of Moringa oleifera Leaf Polyphenol-Loaded Phytosome Delivery System against Breast Cancer Cell Lines. Molecules, 27(14). https://doi.org/10.3390/molecules27144430

Zakaria, N., Safrida, Y. D., & Jannah, R. (n.d.). Formulasi dan Evaluasi Stabilitas Fisika Sirup Poliherbal yang Mengandung Ekstrak Daun Kelor, Rimpang Kunyit, dan Rimpang Jahe Secara Uji Stabilitas Dipercepat Formulation and Evaluation of Physical Stability of Polyherbal Syrup Containing Extract of Moringa Leaf, Turmeric Rhizome, and Ginger Rhizome Using Accelerated Stability Test. Jurnal Sains Dan Kesehatan (J. Sains Kes.) 2024, 6(3). https://doi.org/10.25026/jsk.v6i3.2097

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Published

2024-10-30

How to Cite

Nuha, K., Efriana, C., & Kamal, S. (2024). PERBEDAAN EFEKTIFITAS VARIAN DOSIS DARI PEMBERIAN EKSTRAK DAUN KELOR TERHADAP PENURUNAN INTENSITAS DISMENOREA PRIMER . Jurnal Kesehatan Tambusai, 5(4), 10313–10322. https://doi.org/10.31004/jkt.v5i4.35447