TELANG FLOWER EXTRACT IN OBESE WHITE MALE WISTAR RAT MODEL DERMAPEN WOUND HEALING: HAIR GROWTH AND HISTOPATHOLOGICAL SKIN TISSUE CHARACTERISTICS

Authors

  • Silvia Fransisca Master Study Program in Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, Prima Indonesia University, Medan
  • Riva Nita Harmila Master Study Program in Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, Prima Indonesia University, Medan
  • Widyaningsih Oentari Master Study Program in Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, Prima Indonesia University, Medan

DOI:

https://doi.org/10.31004/jkt.v5i1.24576

Keywords:

Telang Flower, Hair Growth, Skin, Obesity

Abstract

Hair and skin defend against environmental hazards. Antioxidants like flavonoids and peptides in Telang flowers can improve health and treat many diseases. Telang flower extract cream (Clitoria ternatea) was tested for its effects on hair development, dermapen scar healing, and histopathology in obese male Wistar strain white rats (Rattus norvegicus). The Pharmacology and Therapy Laboratory, Department of Medicine, University of North Sumatra, conducted a true experimental research study with a post-test-only control group design from October to December 2023. The samples were 24 Wistar rats in 4 groups. Telang flower extract was given to groups 1, 2, 3, and 4 at 2.5%, 5%, and 7% per kg per body weight. Research data was handled with SPSS 25.0 for Windows. Treatment group 3 received 7% Telang flower extract and had the most hair growth. Telang flower extract at 2.5%, 5%, and 7% concentrations improves wound healing and has dense collagen. Thus, Telang flowers accelerate wound healing and hair development in fat persons.

References

Almohanna, H. M., Ahmed, A. A., Tsatalis, J. P., & Tosti, A. (2019). The Role of Vitamins and Minerals in Hair Loss: A Review. Dermatology and Therapy, 9(1), 51–70. https://doi.org/10.1007/s13555-018-0278-6

Amelia, Y., Rostamailis, & Rosalina, L. (2017). Pemanfaatan kecambah tauge untuk mengatasi kerontokan rambut wanita berjilbab. E-Journal Home Economic and Tourism, 14(1), 1–14. http://ejournal.unp.ac.id/index.php/jhet/article/view/7211

Balato, N., Megna, M., Ayala, F., Balato, A., Napolitano, M., & Patruno, C. (2014). Effects of climate changes on skin diseases. Expert Review of Anti-Infective Therapy, 12(2), 171–181. https://doi.org/10.1586/14787210.2014.875855

Caballero, B. (2019). Humans against Obesity: Who Will Win? Advances in Nutrition, 10, S4–S9. https://doi.org/10.1093/advances/nmy055

Cahyaningsih, E., Yuda, P. E. S. K., & Santoso, P. (2019). (Phytochemical Screening And Antioxidant Activity Of Telang Flower Extract (Clitoria Ternatea L.) Using UV-VIS Spectrophotometry). Jurnal Ilmiah Medicamento, 5(1), 51–57. https://doi.org/10.36733/medicamento.v5i1.851

Chooi, Y. C., Ding, C., & Magkos, F. (2019). The epidemiology of obesity. Metabolism: Clinical and Experimental, 92, 6–10. https://doi.org/10.1016/j.metabol.2018.09.005

Egambaram, O. P., Kesavan Pillai, S., & Ray, S. S. (2020). Materials Science Challenges in Skin UV Protection: A Review. Photochemistry and Photobiology, 96(4), 779–797. https://doi.org/10.1111/php.13208

El-Domyati, M., Hosam, W., Moftah, N. H., Abdel Raouf, H., & Saad, S. M. (2017). Hair follicle changes following intense pulsed light axillary hair reduction: histometrical, histological and immunohistochemical evaluation. Archives of Dermatological Research, 309(3), 191–202. https://doi.org/10.1007/s00403-017-1714-7

Erdo?an, B. (2017). Anatomy and Physiology of Hair. In Z. Kutlubay & S. Serdaroglu (Eds.), Hair and Scalp Disorders (pp. 13–27). IntechOpen. https://doi.org/10.1016/B0-44-306557-8/50208-2

Farahani, M., & Shafiee, A. (2021). Wound Healing: From Passive to Smart Dressings. Advanced Healthcare Materials, 10(16), 1–32. https://doi.org/10.1002/adhm.202100477

Gaytos, C. E. G., & Lumagbas, N. A. A. (2020). Acceptability of Asian Blue Pea Flower (Clitoria Ternatea) Ice Cream. SSRN Electronic Journal, December. https://doi.org/10.2139/ssrn.3517731

Ghozali, I. (2018). Aplikasi Analisis Multivariate dengan Program IBM SPSS 25. In Badan Penerbit Universitas Diponegoro.

Ginting, E. E., Rumanti, R. M., Savira, D., Ginting, P., Marbun, N., & Leny, L. (2022). In Vivo study of Antidiabetic Activity from Ethanol Extract of Clitoria ternatea L. Flower. Journal of Drug Delivery and Therapeutics, 12(6), 4–9. https://doi.org/10.22270/jddt.v12i6.5759

Guo, E. L., & Katta, R. (2017). Diet and hair loss: effects of nutrient deficiency and supplement use. Dermatology Practical & Conceptual, 7(1), 1–10. https://doi.org/10.5826/dpc.0701a01

Herrero-Fernandez, M., Montero-Vilchez, T., Diaz-Calvillo, P., Romera-Vilchez, M., Buendia-Eisman, A., & Arias-Santiago, S. (2022). Impact of Water Exposure and Temperature Changes on Skin Barrier Function. Journal of Clinical Medicine, 11(2). https://doi.org/10.3390/jcm11020298

Kareem, J. B., Yser, H. T., Turab, M. K. A., & Makki, U. M. (2020). Effect of Malnutrition, Hormones Disturbance and Malondialdehyde on Hair Loss in Women: Patients At Al-Sader Educational Hospital, Basrah Governorate, Iraq - a Case Study. Biochemical and Cellular Archives, 20(2), 5701–5708.

Kutlubay, Z., & Serdaroglu, S. (2017). Introductory Chapter: Hair Loss Chapter. In Hair and Scalp Disorders (pp. 3–10). IntechOpen. https://doi.org/http://dx.doi.org/10.5772/66984

Lee, S.-I., Kim, J.-W., Lee, Y.-K., Yang, S.-H., Lee, I.-A., Suh, J.-W., & Kim, S.-D. (2011). Anti-obesity Effect of Monascus pilosus Mycelial Extract in High Fat Diet-induced Obese Rats. Journal of Applied Biological Chemistry, 54(3), 197–205. https://doi.org/10.3839/jabc.2011.033

Lemasters, J. J., Ramshesh, V. K., Lovelace, G. L., Lim, J., Wright, G. D., Harland, D., & Dawson, T. L. (2017). Compartmentation of Mitochondrial and Oxidative Metabolism in Growing Hair Follicles: A Ring of Fire. Journal of Investigative Dermatology, 137(7), 1434–1444. https://doi.org/10.1016/j.jid.2017.02.983

Libby, P. (2021). The changing landscape of atherosclerosis. Nature, 592(7855), 524–533. https://doi.org/10.1038/s41586-021-03392-8

Marpaung, A. M. (2020). Tinjauan manfaat bunga telang (clitoria ternatea l.) bagi kesehatan manusia. Journal of Functional Food and Nutraceutical, 1(2), 63–85. https://doi.org/10.33555/jffn.v1i2.30

Muscogiuri, G., Barrea, L., Laudisio, D., Pugliese, G., Salzano, C., Savastano, S., & Colao, A. (2019). The management of very low-calorie ketogenic diet in obesity outpatient clinic: A practical guide. Journal of Translational Medicine, 17(1), 1–9. https://doi.org/10.1186/s12967-019-2104-z

Notoatmodjo, S. (2022). Metodologi Penelitian Kesehatan (3rd ed.). Jakarta: Rineka Cipta.

Parker, E. R. (2021). The influence of climate change on skin cancer incidence – A review of the evidence. International Journal of Women’s Dermatology, 7(1), 17–27. https://doi.org/10.1016/j.ijwd.2020.07.003

Pertiwi, F. D., Rezaldi, F., & Puspitasari, R. (2022). Uji Aktivitas Antibakteri Ekstrak Etanol Bunga Telang (Clitoria ternatea L.) Terhadap Bakteri Staphylococcus epidermidis. Biosaintropis (Bioscience-Tropic), 7(2), 57–68. https://doi.org/10.33474/e-jbst.v7i2.471

Rebora, A. (2019). Telogen effluvium: A comprehensive review. Clinical, Cosmetic and Investigational Dermatology, 12(2019), 583–590. https://doi.org/10.2147/CCID.S200471

Stoffel, N. U., El-Mallah, C., Herter-Aeberli, I., Bissani, N., Wehbe, N., Obeid, O., & Zimmermann, M. B. (2020). The effect of central obesity on inflammation, hepcidin, and iron metabolism in young women. International Journal of Obesity, 44(6), 1291–1300. https://doi.org/10.1038/s41366-020-0522-x

Subchan, P., Sofyanti Putri, R., Itsnal Muna, N., Magdalena Hutapea, C., Cahyani, E., & Hidayah, N. (2022). Ekstrak Bunga Telang (Clitoria ternatea L.) Menghambat Peningkatan Ekspresi Gen MMP-1 pada Kulit Tikus Wistar yang Terpapar Sinar Ultraviolet B. Journal of Midwifery and Health Science of Sultan Agung, 2, 13–21. https://doi.org/10.30659/jmhsa.v1i2.22

Suganda, T., & Adhi, S. R. (2017). Uji Pendahuluan Efek Fungisida Bunga Kembang Telang (Clitoria ternatea L.) terhadap Jamur Fusarium oxysporum f.sp. cepae Penyebab Penyakit Moler pada Bawang Merah. Agrikultura, 28(3), 136–140. https://doi.org/10.24198/agrikultura.v28i3.15746

Suryawati, A. A. M. A., & Santika, I. W. M. (2023). Potensi dan Efektivitas Farmakologi Ekstrak Kembang Telang (Clitoria ternatea L.) sebagai Suplemen Antidiabetes: A Systematic Review. Prosiding Workshop Dan Seminar Nasional Farmasi, 2(Dm), 61–76. https://doi.org/10.24843/wsnf.2022.v02.p05

Suwarno, B., & Nugroho, A. (2023). Kumpulan Variabel-Variabel Penelitian Manajemen Pemasaran (Definisi & Artikel Publikasi) (1st ed.). Bogor: Halaman Moeka Publishing.

Wu, W., Yang, J., Tao, H., & Lei, M. (2022). Environmental Regulation of Skin Pigmentation and Hair Regeneration. Stem Cells and Development, 31(5–6), 91–96. https://doi.org/10.1089/scd.2022.29011.wwu

Zhang, W., Fan, M., Wang, C., Mahawar, K., Parmar, C., Chen, W., & Yang, W. (2021). Hair Loss After Metabolic and Bariatric Surgery: a Systematic Review and Meta-analysis. Obesity Surgery, 31(6), 2649–2659. https://doi.org/10.1007/s11695-021-05311-2

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Published

2024-02-22

How to Cite

Fransisca, S. ., Harmila, R. N. ., & Oentari, W. . (2024). TELANG FLOWER EXTRACT IN OBESE WHITE MALE WISTAR RAT MODEL DERMAPEN WOUND HEALING: HAIR GROWTH AND HISTOPATHOLOGICAL SKIN TISSUE CHARACTERISTICS. Jurnal Kesehatan Tambusai, 5(1), 327–340. https://doi.org/10.31004/jkt.v5i1.24576

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