ETHANOLIC EXTRACT SIRIH CHINA (Peperomia Pellucida) ON REDUCING URIC ACID LEVELS IN WISTAR RATS MODEL HYPERURICEMIA WITH HIGH FRUCTOSE INDUCED
DOI:
https://doi.org/10.31004/jkt.v4i3.17234Keywords:
hiperurikemia, fruktosa, sirih Cina, peperomia pellucidaAbstract
Daun Sirih China merupakan tanaman yang banyak tumbuh di daerah lembab dengan persebaran yang banyak sehingga jarang digunakan dengan kebutuhan yang jelas dan komersial, namun secara empiris sudah banyak digunakan sebagai obat tradisional yang dipercaya berperan penting dalam menurunkan kadar asam urat akan tetapi masih belum banyak penelitian yang menemukan dosis penggunaan yang tepat. Oleh karena itu, penelitian ini bertujuan untuk mengetahui efek antihiperurisemik daun sirih cina (Perperomia pellucida) dan penggunaan dosis yang tepat pada tikus Wistar yang diinduksi hiperurisemia akibat fruktosa tinggi. Penelitian ini menggunakan desain penelitian eksperimental murni, menggunakan desain kelompok kontrol pretest-posttest, untuk mengevaluasi efek antihiperurisemik ekstrak daun sirih China. Hewan percobaan dibagi menjadi 6 kelompok (Kontrol, CMC, Allopurinol dan kelompok variasi dosis 250, 350 dan 500 mg / KgBB, pengukuran kadar asam urat dilakukan pada minggu ke 0, 6, 9, 12 dan 15. Penelitian ini menyelidiki efek antihiperurisemik ekstrak etanol daun sirih Cina Perperomia pelusida pada tikus Wistar yang diinduksi hiperurisemia. Menggunakan desain kelompok kontrol pretest-posttest, penelitian ini menemukan bahwa ekstrak tersebut secara signifikan mengurangi kadar asam urat, terutama pada dosis 350 mgKgBB. Temuan ini menunjukkan aplikasi terapeutik potensial dari ekstrak daun sirih Cina dalam mengelola hiperurisemia (P<0,05).References
Abbasi F., Malhotra D., Mathur A., Reaven G.M., Molina C.R. (2012). Body Mass Index and Waist Circumference Associate To A Comparable Degree With Insulin Resistance and Related Metabolic Abnormalities in South Asian Women and Men. Diabetes and Vascular Disease Research 2012. 9 (4): 296-300.
Abougalambou S S I, Mohamed M, Syed Sulaiman SA, Abougalambou AS, Hassali MA. (2010). Current clinical status and complications among type 2 diabetic patients in Universiti Sains Malaysia hospital. International Journal of Diabetes Mellitus 2 : 184–188
Al-naggly S, Miller DS, Yudkin J. (1970). Changes in body composition and metabolism induced by sucrose in the rat. Nutr Metab. 1970; 12:193-19.
Caroline L Benn. Pinky Dua, Rachel Gurrel, Peter Loudon, Andrew Pike, R.lan Strorer and Ciara Vangjeli. (2018). Physiology of Hyperuricemia and Urate-Lowering Treatements. Journal of review Medicine. Frontieres in Medicine. 31 May 2018: Article 150: 1-25
Dimas A, Advitasari YD and Nugraheni B. (2020). Aktivitas Antihiperurisemia mikroenkapsulasi ekstrak kulit melinjo (Gnetum gnemon L) Secara In vivo. Vol 9 No 1 pp 1-6
Ghezzi C, Donald F and Ernest W. (2018). Physiology of renal glucose handling via SGLT1, SGLT2 and GLUT9. Journal Review Diabetolgia. Doi.org/ 10.1007/ s00125 -018-4656-5
Guido L, Franco D, Sorriento D, Strisciuglio T, Barbato E and Morisco C. 2021. Modulation of Insulin Sensitivity by Exercie Training: Implications for Cardiovascular Prevention. Journal of Cardiovascular Translational Research. 14: 256 – 270
Harahap, AM; Machrina Y. Effect of Physical Activity Fast Interval Training and Provision of Melinjo Skin Extract (Gnetum Gnemon) On Express-ion of URAT1 Transpo rter, GLUT9 And SGLT2 In Hyperuricemia Insulin Resis tance. 2023. The Journal of Biosciences. 8(1). 14-23.
Hasan AE, Husnawati and Setiyono A. (2020). Efektivitas ekstrak kulit melinjo (Gnetum gnemon) pada penurunan kadar asam urat paad tikus putih (rattus novergicus) hiperurisemia. Curr Biochem.2020. 7(1): 21-28
Jaksen Bostjan, Barbara J, Pajek M and Pajek J. (2019). Uric acid and plant- Based Nutrition. Review article Njutrient. 11.1736; doi:10.339/nu11081736
Kushiyama A, Yusuke N, Yasuka M, Takeshi Y, Koji U, Takoi I, Yuki I, Hideyuki S, Midori F, Hiraku O, and Tomoichiro A. (2016). Role of Uric Acid Metabolism-Related Inflammation in the Pathogenesis of Metabolic Syndrome Components Such as Atherosclerosis and Nonalcoholic Steatohepatitis. Review Article. Volume 2016, Article ID 8603164, 15 pages http:/ dx.doi.org 10.1155/2016 8603164.
Kumar, B., & Lenert, P. (2016). Gout and African American reducing dispaties. Amerika: Clevaland Clinic Jurnl of Medicine.
Lai Jen H, Dhue FL, Hung LF, Huang CY, Shiu L, Lin C, Cheng F, Yen B, Jun L and Ho LJ. (2017). Physiological concentrations of soluble uric acid are chondroprotective and anti inflammatory. Scientifitct report of nature.Vol 7 No 2359. Doi. 10.1038/s41598-017-02640-0
Moser O, Tschakert G, Mueller A, Groeschl W, Pieber TR, Obermayer-Pietsch B, et.al. (2015). Effects of High-Intensity Interval Exercise versus Moderate Continuous Exercise on Glucose Homeostasis and Hormone Response in Patients with Type 1 Diabetes Mellitus Using Novel Ultra-Long-Acting Insulin. PLOS ONE | DOI:10.1371/journal. p 1-17
Mount D. (2016). Molecular Physiology of Uric Acid Homeostasis The Molecular Physiology of Uric Acid HOneostatic. Annu Rev Physiol. 77. 323-45
Pavelcopa K, Jana B, Marketa P, Eliska B, Karel P, and Blanka S. (2020). Evaluation of the Influence of Genetic Variants of SLC2A9 (GLUT9) and SLC22A12 (URAT1) on the Development of Hyperuricemia and Gout. Journal of clinical Medicinne. 9 2510, doi:10.339o/jcm9082510
Skleryk JR, Karagounis LG, Hawley JA, Sharman MJ, Laursen PB, et al. 2013. Two weeks of reduced volume sprint interval or traditional exercise training does not improve metabolic functioning in sedentary obese men. Diabetes Obes Metab. 15:1146–1153Wang Xiaoying, Jiangbing Zhou, Bin Shi, Xiaolei Guo and Qunchao Yan. 2016. Hypouricemic and neprhoprotective effects of jianphi Huasi decocion in rat model of hyperuricemia. International Journal of Experimental Medical. Vol 9 No 1: 455-465
Weiss M, Steiner DF, and Philipson LH. 2014. Insulin Biosynthesis, Secretion, Structure, and Structure – Activity Relationships. in Endotext Comprehensive Free online Endocrinology book. De Groot LJ, Chrousos G, Dungan K et al, editors. South Dartmouth (MA). MD Text.com.Inc; 2000
Yetti Machrina, Harun Al Rasyid Damanik, Ambrosius Purba, dan Dharma Lindarto. 2019. Effect Various type of exercise to Insr Gene expression skeletal muscle insuline receptor and Insuline resistence On Diabetes Mellitus Type-2 model Rats. International Journal of Healts Science. Volume 6 No 4: 50-56
Downloads
Published
Issue
Section
License
Copyright (c) 2023 Armansyah Maulana Harahap
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work’s authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal’s published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
