EVALUASI EFEKTIVITAS ANALGESIK JAMU “X” PADA MENCIT SWISS WEBSTER
DOI:
https://doi.org/10.31004/jkt.v4i3.17095Keywords:
Analgesik, Efektivitas, Geliat, ProteksiAbstract
Jamu X merupakan jamu yang popular digunakan untuk meredakan nyeri. Jamu menjadi alternatif pengobatan dengan efek samping minimal. Akan tetapi belum ada penelitian terkait pengujian aktivitas analgesik jamu X. Penelitian ini bertujuan untuk mengevaluasi efektivitas analgesik dan mengetahui dosis efektif analgesik jamu X pada mencit yang diinduksi asam asetat 1%. Mencit uji dibagi menjadi 5 kelompok yaitu kontrol negatif (CMC-Na 0,5% b/v), kontrol negatif induksi (CMC-Na 0,5% b/v dan asam asetat), kontrol positif (asam mefenamat 65 mg/kg BB), kelompok uji jamu X dengan konsentrasi dosis 39 mg dan 78 mg. Efektivitas analgesik jamu X dapat ditentukan dengan melihat refleks geliat seperti kepala dan kaki meregang, dan perut menyentuh dasar kandang setelah diinduksi asam asetat 1%. Gejala ini dapat dihilangkan dengan analgetik. Data hasil uji dianalisis secara statistik dengan menggunakan software SPSS 26. Didapatkan persentase proteksi kontrol negatif CMC-Na yakni 0%, kontrol positif asam mefenamat yakni 54,76%. Untuk persentase proteksi efektifitas analgesik jamu X dosis 39 mg yakni 11,5% dan dosis 78 mg yakni 33,5%. Dari hasil penelitian diperoleh simpulan pada dosis 78 mg jamu X pada mencit memiliki persentase proteksi tertinggi yakni sebesar 33,5%. Oleh karena itu, efektivitas jamu X dalam mengatasi nyeri pada mencit yang diinduksi asam asetat 1% berada pada dosis 39 mg.References
Bajuber, Q., Indiastuti, D. N., & Kusuma, E. (2020). Efek Analgesik Ekstrak Etanol Zingiber cassumunar Roxb. pada Mencit dengan Metode Writhing Test. Jurnal Medik Veteriner, 3(1), 45. https://doi.org/10.20473/jmv.vol3.iss1.2020.45-50
Cahyaningsih, E., & Suwarni, E. (2017). Uji Efek Infusa Daun Kayu Putih (Melaleuca trichostachya Lindl.) Pada Mencit Jantan (Mus musculus L.). Jurnal Ilmiah Medicamento, 3(1), 7–11. https://doi.org/10.36733/medicamento.v3i1.1038
Hanum, Z., Pratiwi, R., & Febriyanti, R. (2021). Uji Aktivitas Analgetik Kombinasi Ekstrak Etanol Daun Pepaya (Carica papaya L.) Dan Umbi Bawang Putih (Allium sativum L.) Terhadap Mencit Putih Jantan. Jurnal Ilmiah Farmasi, x(x).
Hasimun, P., Suwendar, & Ernasari, G. I. (2014). Analgetic Activity of Papaya (Carica papaya L.) Leaves Extract. Procedia Chemistry, 13, 147–149. https://doi.org/10.1016/j.proche.2014.12.019
Hassan, F. I., Zezi, A. U., Yaro, A. H., & Danmalam, U. H. (2015). Analgesic, anti-inflammatory and antipyretic activities of the methanol leaf extract of Dalbergia saxatilis Hook.F in rats and mice. Journal of Ethnopharmacology, 166, 74–78. https://doi.org/10.1016/j.jep.2015.03.007
Jiang, W., Tang, M., Yang, L., Zhao, X., Gao, J., Jiao, Y., Li, T., Tie, C., Gao, T., Han, Y., & Jiang, J. D. (2022). Analgesic Alkaloids Derived From Traditional Chinese Medicine in Pain Management. Frontiers in Pharmacology, 13(May), 1–25. https://doi.org/10.3389/fphar.2022.851508
Karbab, A., Mokhnache, K., Ouhida, S., Charef, N., Djabi, F., Arrar, L., & Mubarak, M. S. (2020). Anti-inflammatory, analgesic activity, and toxicity of Pituranthos scoparius stem extract: An ethnopharmacological study in rat and mouse models. Journal of Ethnopharmacology, 258(April), 112936. https://doi.org/10.1016/j.jep.2020.112936
Kumar Paliwal, S., Sati, B., Faujdar, S., & Sharma, S. (2017). Studies on analgesic, anti-inflammatory activities of stem and roots of Inula cuspidata C.B Clarke. Journal of Traditional and Complementary Medicine, 7(4), 532–537. https://doi.org/10.1016/j.jtcme.2016.08.005
Lalan, B. K., Hiray, R. S., & Ghongane, B. B. (2015). Evaluation of analgesic and anti-inflammatory activity of extract of Holoptelea integrifolia and Argyreia speciosa in animal models. Journal of Clinical and Diagnostic Research, 9(7), FF01–FF04. https://doi.org/10.7860/JCDR/2015/12059.6200
Lara, A. D., Elisma, & Sani, F. K. (2021). Uji Aktivitas Analgesik Infusa Daun Jeruju (Acanthus ilicifolius L.) Pada Mencit Putih Jantan (Mus musculus) Test The Analgesic Activity Of Jeruju Leaf Infusion (Acanthus ilicifolius L.) On Male White Mice (Mus musculus). Indonesian Journal of Pharma Science, 3(2), 71–80.
Li, X., Wang, X., Zhao, M., & Liu, C. (2022). The Chemical and Pharmacological Research Progress on a Kind of Chinese Herbal Medicine , Fructus Malvae. 1–30.
Lu, Y., Wu, H., Yu, X., Zhang, X., Luo, H., Tang, L., & Wang, Z. (2020). Traditional Chinese Medicine of Angelicae Pubescentis Radix: A Review of Phytochemistry, Pharmacology and Pharmacokinetics. Frontiers in Pharmacology, 11(March), 1–16. https://doi.org/10.3389/fphar.2020.00335
Octavianus, S., & Lolo, W. A. (2014). Uji Efek Analgetik Ekstrak Etanol Daun Pepaya (Carica Papaya L) Pada Mencit Putih Jantan (Mus Mucculus). Pharmacon, 3(2), 87–92.
Ponggele, R. M. (2013). Uji Efek Analgesik Ekstrak Kulit Manggis (Garcinia Mangostana L.) Pada Mencit Swiss (Muss Musculus). Jurnal E-Biomedik, 1(2), 796–801. https://doi.org/10.35790/ebm.1.2.2013.3245
Praditapuspa, E., Kresnamurti, A., & Faizah, A. (2020). Uji Aktivitas Analgesik Minyak Ikan Salmon Pada Mencit Putih (Mus Musculus) Jantan Galur Balb/C Dengan Metode Hot Plate. Jurnal Sains Dan Kesehatan, 2(4), 259–264. https://doi.org/10.25026/jsk.v2i4.130
Rahman, S. M. M., Atikullah, M., Islam, M. N., Mohaimenul, M., Ahammad, F., Islam, M. S., Saha, B., & Rahman, M. H. (2019). Anti-inflammatory, antinociceptive and antidiarrhoeal activities of methanol and ethyl acetate extract of Hemigraphis alternata leaves in mice. Clinical Phytoscience, 5(1). https://doi.org/10.1186/s40816-019-0110-6
Sartika, D. (2019). Uji Efek Anlagetik Ekstrak Etanol Buah Cabai (Capsicum annuum L.) Terhadap Mencit Putih Jantan. Scientia?: Jurnal Farmasi Dan Kesehatan, 9(1), 36.
https://doi.org/10.36434/scientia.v9i1.220
Syamsul, E. S., Andani, F., & Budianti Soemarie. (2016). Uji Aktivitas Analgetik Ekstrak Etanolik Daun Kerehau (Callicarpa longifolia Lamk.) Pada Mencit Putih. Traditional Medicine Journal, 21(2), 99–103.
Wang, L., Zhang, J., Hong, Y., Feng, Y., Chen, M., & Wang, Y. (2013). Phytochemical and pharmacological review of da Chuanxiong formula: A famous herb pair composed of chuanxiong rhizoma and gastrodiae rhizoma for headache. Evidence-Based Complementary and Alternative Medicine, 2013. https://doi.org/10.1155/2013/425369
Winarti, L., & Wantiyah. (2011). Uji Efek Analgetika Ekstrak Rimpang Temu Kunci (Boesenbergia pandurata (Roxb.) Schlechter Pada Mencit Jantan Galur Swiss. Majalah Obat Tradisional, 16(1), 26–33.
Zulkifli, & Octaviany, E. E. (2019). Uji Efek Analgetik Ekstrak Akar Binasa (Plumbago indica L) Asal Kabupaten Sidenreng Rappang Terhadap Mencit Dengan Metode Writhing Reflex Test. Jurnal Herbal Indonesia, 1(1), 43–49.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Abdurrachman Ananta, Iman Surya Pratama, Annida Dhuhani, Hidayatul Azizah, Mariska Sofiana Dewi, Naufal Auliya Amrullah, Rinta Putri Yanuar
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work’s authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal’s published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
